Is Mirtazapine Safe for Cats?

“My cat was diagnosed with chronic kidney disease earlier this year. He was not eating well and had lost a lot of weight. I started him on Mirtazapine, but after about 3 days, he started having seizures. He was still eating well, so I kept him on the Mirtazapine. After about a week, he stopped eating. I took him off the drug and tried to get him to eat using baby food and other tricks we often use when we have a sick cat that won’t eat. Nothing worked and he became weaker by the day. At this point, I wanted to get him in to see a vet, but he died that night in my arms as we were getting ready to go to the pet hospital for an emergency visit. I have heard of other people who have had similar experiences with Mirtazapine for cats. Please do not use Mirtazapine for your cat unless you are prepared for something like this to happen!”

Mirtazapine Killed My Cat

Is Mirtazapine bad for cats?

Cats that are allergic or hypersensitive to mirtazapine should not take it. Mirtazapine should be used cautiously in cats with liver and/or kidney disease. The use of this medication should also be avoided in pets that have had seizures or are prone to seizures.

“My cat, Misha, was 12 years old and had been generally healthy her whole life. However last summer she began losing weight and appetite. The vet prescribed Mirtazapine at that time because it is an appetite stimulant as well as an anti-anxiety medication for cats. In October she looked terrible and was very lethargic. A blood test showed she had a severe kidney failure.”

Mirtazapine has also been known to interact with other medications, so it’s important to discuss all other medications your pet may be taking with your veterinarian before beginning treatment.

Mirtazapine is commonly prescribed for the treatment of nausea, vomiting, and appetite loss in cats.

The first use of mirtazapine in cats was to stimulate appetite. Cats are notoriously picky eaters. Because they can be so finicky, they will often refuse to eat if they don’t like the food or if they are stressed, anxious, or depressed.

Is mirtazapine harmful to cats?

The most common adverse effects include:

  • vocalization
  • agitation
  • vomiting
  • abnormal gait/ataxia
  • restlessness
  • tremors/trembling
  • hypersalivation
  • tachypnea
  • tachycardia
  • lethargy

Like many medications, it can be dangerous if accidentally ingested by a pet that was not prescribed the medication by a veterinarian.

Can a cat overdose on Mirtazapine?

Although relatively safe when used as directed, mirtazapine can have serious consequences if it is ingested by pets at higher-than-recommended doses or if it is administered to patients with certain underlying medical conditions.

Can Mirtazapine cause seizures in cats?

Yes. In rare cases, Mirtazapine has been known to cause seizures in cats. If your cat has a history of seizures (or has a condition that predisposes him to seizures), talk with your veterinarian before giving mirtazapine.

Can Mirtazapine cause aggression in cats?

In most cases, the use of Mirtazapine in cats is associated with a reduction in aggression. However, there are also instances where Mirtazapine causes aggression in cats.

Some cats may experience changes in behavior when taking mirtazapine, such as becoming more affectionate or playful. These behavioral changes are usually mild and temporary.

“My cat was given mirtazapine for about two weeks. She was given it after she stopped eating due to the stress of moving. After she received the medication, she started eating again. However, her personality changed drastically. She became aggressive and violent. It was very difficult to even pet her because she was so mean.

Also, she started having problems with urinating in the litter box. The vet said that it was due to a urinary infection and gave her an antibiotic. I’m not sure if there is any connection between the mirtazapine and the urinary tract infection, but it’s possible it has some side effects that would cause this to happen.”

How quickly does mirtazapine work cats?

Mirtazapine usually starts working within 1 to 2 days. The length of time your cat can be on an anti-depressant will depend on their individual situation. Some owners may see results in a few days, although it may take up to two weeks before you see the full benefit of mirtazapine.

“My cat has been on the Mirtazapine for 5 days now and is doing very well. He is eating, drinking, and walking well. His energy appears to be returning slowly. This pill took a while to kick in but I feel it will continue to help him.”

Positive reviews

Mirtazapine reviews from cat owners are mostly positive. Mirtazapine is becoming more widely used as an appetite stimulant in veterinary medicine as well.

“I just recently started using Mirtazapine for my cat and it has been so helpful. My cat is an indoor cat but he was constantly meowing and wanting to go out. I tried everything, but nothing worked. Even when I would let him out he would sit on the top of the shed in the backyard and cry like he wanted to go inside. He would even try to run in the house when I let him back in. After a week of taking Mirtazapine, he settled down and started acting normal again.”

“I just recently switched my cat from fluoxetine to mirtazapine. This was after we found out that the fluoxetine made him a lot more aggressive. Since the switch, he has been so much better and calmer. I am very happy with this med!!!!”

“My cat is currently on Mirtazapine and it has been a miracle drug for us! She is a rescue who came to us with trauma and shows separation anxiety every time we leave, but this medication works wonders for her! We give her a dose before leaving and she sleeps through our absence. It is a godsend!”

Using mirtazapine as an appetite stimulant in cats

Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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