Is Profender Safe for Cats?

Profender is used by many animal owners as a preventive and curative treatment for worms in cats and dogs. However, there are also reports from cat owners who say that Profender killed their cats or caused them to fall ill. What are the risks of Profender and can Profender kill a cat? Let’s find out.

Profender Killed My Cat

“I had a beautiful 10-year-old cat named ‘Big Girl’, who lost her fight to Profender. She was not the first and will not be the last. This product is killing our beloved pets!”

“I chose this product because the applicator is so simple, I didn’t think twice. I applied it as directed and everything seemed fine until about 2 days later… She began vomiting and having diarrhea, refusing food and water, suddenly losing weight, and losing control of her bowels. I rushed her to the vet and they said it was too late… She died in my arms on the way to the emergency vet hospital.”

“I used Profender on my cat about a week ago. About 24 hours after the application, she started to get very sick. How sick? She was vomiting, lethargic, and not eating. I took her to the vet and was told it was an adverse reaction to the Profender. Several more days went by and she got worse. The vet put her on IV fluids and anti-nausea meds. No improvement. I called my regular vet who said it could be the Profender, but they had never heard of such a thing before at their office!! 3 days later we had to put my cat down!”

“I have a cat that is very hard to give pills to. My vet gave me the tube of Profender. My cat is 16 pounds, so I put the dose on the back of her neck. She was fine for about 24 hours and then we started noticing she was having a lot of trouble walking. She was wobbling all over the place, slipping and falling off things, etc. They gave her pain meds, but she can’t walk at all now. After doing some research online I found a ton of other stories like mine that happened.”

Is Profender toxic to cats?

In some cases, a cat may experience an allergic reaction to Profender which can be fatal if left untreated.

Allergic reactions are typically seen within 12 hours of application and include vomiting, lethargy, diarrhea, not eating or drinking, drooling, and tremors or seizures.

Profender is a topical treatment for intestinal worms in cats. It is directly applied to the skin of the cat’s neck at the base of the skull.

The active ingredient inside Profender is absorbed into the bloodstream and distributed throughout the body to kill parasites such as roundworms, hookworms, and tapeworms.

What are the side effects of Profender for cats?

The most common side effects of Profender include:

  • Licking/excessive grooming
  • Scratching at the treatment site
  • Salivation
  • Lethargy
  • Loss of hair
  • Agitation/nervousness
  • Vomiting
  • Diarrhea
  • Eye irritation
  • Respiratory irritation
  • Shaking/tremors

If you notice any side effects after applying Profender, do NOT give your cat another dose of Profender for intestinal worms. If your cat experiences vomiting or diarrhea within 24 hours of application, make sure he has plenty of water to drink so he does not become dehydrated. You should contact your veterinarian immediately for advice if this happens.

How long does Profender last in cats?

The active ingredients in Profender® are rapidly absorbed into the bloodstream through the skin within 24 hours following treatment. Once absorbed, Profender® moves into the body’s tissues and fluids. Profender® works against adult worms in a single dose, killing 97% of tapeworms, roundworms, and hookworms in cats within 3 days after treatment.

Does Profender cause lethargy?

Some cats may experience lethargic behavior after deworming. This is normal and should subside in a few days.

Do cats poop out worms after being dewormed?

After treatment with Profender, your cat may vomit dead worms and pass them in her stool. This is normal and indicates that the medication was effective at killing the worms.

If you do not see any signs of worms after 3 days, it’s likely that she does not have worms, but if you want to be sure, then it would probably be best to take her back to her vet for a follow-up appointment.

Positive reviews of Profender

“My cats are not huge fans of taking medication, but it is a necessary part of keeping them healthy. The Profender for Cats is an excellent product to use for worm prevention and/or treatment. It’s easy to use and gives them peace of mind when they have to go outside. It’s been around for a while, so I feel confident in recommending it.”

“I live on the edge of town where there are still a lot of stray cats. There is a high risk that my cats will get worms from those cats, so I give them the Profender once a month as preventative care. I like that they don’t have to take a pill or eat something weird. My cats hate pills and will do anything they can to not take them. This works well for us because there’s no fussing or fighting about it.”

“I have been using Profender for about 3 years now. It has been very easy to use and has worked well for my cats.”

“I’ve used a lot of these types of products on my cats and I have to say that this one is the best so far. The others either made them sick or did not work at all. Profender has been the only product that actually works, and it’s really easy to use. My cat didn’t seem to mind it at all, and I’ve had no issues with him afterward. It also does exactly what it’s supposed to do, which is kill the worms. I would recommend this product for anyone who has a cat that is dealing with worms.”


Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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