Side Effects of Revolution Plus for Cats

Keeping our feline friends healthy and free from pesky parasites is a priority for every cat owner. One of the widely used preventive medications is Revolution Plus. While generally considered safe and effective, some cats may experience side effects. In this comprehensive guide, we’ll delve deep into what Revolution Plus is, the possible side effects, and how to handle any adverse reactions.

What is Revolution Plus for Cats?

Revolution Plus is a comprehensive, topical medication used to protect cats against a wide range of parasites. This includes fleas, ticks, ear mites, roundworms, hookworms, and even heartworms. The product contains two active ingredients, Selamectin and Sarolaner, working synergistically to provide broad-spectrum coverage.

Side Effects of Revolution Plus: What to Look Out For

Despite its effectiveness, some cats might exhibit side effects from the treatment. Below are some potential adverse reactions:

Localized Reactions

Some cats might show temporary dermal irritation at the application site. This could range from mild redness and itching to temporary hair loss.

Gastrointestinal Disturbances

In some instances, cats might exhibit hypersalivation, vomiting, or diarrhea post-application. Decreased appetite can also be a sign of gastrointestinal discomfort.

General Lethargy

It’s not uncommon for cats to become lethargic after the application of Revolution Plus. While this side effect is generally temporary, extended periods of lethargy should prompt a veterinary consultation.

Pruritus and Muscle Tremors

Cats may also experience pruritus (intense itching) and muscle tremors as potential side effects. These are less common, but if noticed, your vet should be informed.

Handling Adverse Reactions to Revolution Plus

If you notice your cat showing any of the side effects mentioned above, the first step is not to panic. These reactions are typically mild and resolve on their own. However, persistent symptoms or severe reactions like ongoing vomiting, seizures, or extended lethargy warrant immediate veterinary attention.

In case of an adverse reaction, follow these steps:

  1. Monitor Your Cat: Keep a close eye on your cat’s behavior and symptoms. Document any changes, even if they seem minor.
  2. Contact Your Vet: If symptoms persist or worsen, get in touch with your vet immediately. They can provide advice over the phone and may ask to see your cat if necessary.
  3. Keep Your Vet Informed: Even if the side effects subside, inform your vet during your cat’s next check-up. They might adjust the dosage or suggest an alternative medication.

Is Revolution Plus Safe for All Cats?

While Revolution Plus is generally safe for most cats, individual reactions can vary. Cats with certain medical conditions or those that are very young, old, or pregnant may require special considerations. Always consult with your vet before starting any new medication regimen.


Revolution Plus for cats is a reliable choice for parasite prevention, but like all medications, it may cause side effects in some cats. Recognizing these potential adverse reactions and knowing how to respond can help ensure your feline friend remains healthy and comfortable. Always keep the lines of communication open with your vet, and don’t hesitate to reach out if you have concerns about your cat’s health.

FAQs: In-Depth Look at Revolution Plus Side Effects

Q1: Can Revolution Plus cause neurological problems in cats?

While it’s extremely rare, Revolution Plus could potentially cause neurological symptoms in cats, like muscle tremors or seizures. These adverse reactions are generally associated with sensitivity or allergic reactions to the medication or in cases of an accidental overdose. If you notice any signs of neurological disturbances, such as uncoordinated movements, weakness, or excessive shaking, contact your vet immediately.

Q2: What do I do if I accidentally applied too much Revolution Plus?

In cases of accidental overdosing, your cat may exhibit more severe versions of the typical side effects. This could include prolonged vomiting, extreme lethargy, persistent diarrhea, or signs of neurological issues. If you suspect an overdose, contact your vet immediately for guidance. In the meantime, refrain from washing off the medication unless explicitly instructed to do so by a veterinarian, as this could cause the medication to spread to other areas of the cat’s body.

Q3: Is it normal for my cat to lose hair where Revolution Plus was applied?

Temporary hair loss at the application site can occur and is typically not a cause for concern. It usually grows back without intervention. However, if the hair loss persists or if the area appears red, swollen, or infected, consult your vet for further evaluation and treatment.

Q4: Can Revolution Plus be used for kittens or senior cats?

Revolution Plus is approved for use in cats and kittens aged eight weeks and older, with no upper age limit. However, for very young kittens, senior cats, or those with underlying health conditions, it’s crucial to discuss the use of any new medication with your vet to ensure it’s suitable for your pet’s specific health needs.

Q5: Can my cat develop an allergy to Revolution Plus?

As with any medication, it’s possible for a cat to develop an allergic reaction to Revolution Plus. Allergic reactions can range from mild (itching, localized swelling) to severe (difficulty breathing, collapse). If you notice any signs that could indicate an allergic reaction, stop using the product and seek veterinary attention immediately.

Q6: How often should I apply Revolution Plus to my cat?

Revolution Plus should be applied once a month for continuous protection against parasites. However, always follow your vet’s specific instructions regarding the frequency and dosage of any medication, as it may vary based on your cat’s age, weight, and overall health status.

Q7: Can I bathe my cat or allow them to get wet after applying Revolution Plus?

It is generally recommended to avoid bathing your cat for at least two hours after applying Revolution Plus. This allows the medication to be fully absorbed into the skin. However, after this period, occasional bathing or exposure to rain should not affect the medication’s effectiveness. Still, frequent or prolonged water exposure might reduce its duration of efficacy and could necessitate more frequent re-application.

Q8: What happens if my cat ingests Revolution Plus?

While Revolution Plus is intended for topical use, cats may accidentally ingest some of the product while grooming. If only a small amount is ingested, it may cause mild gastrointestinal upset like salivation or vomiting. However, larger amounts could potentially lead to more severe symptoms, such as tremors or loss of appetite. If you suspect your cat has ingested a significant amount of Revolution Plus, contact your vet immediately.

Q9: What parasites does Revolution Plus protect against?

Revolution Plus is designed to offer broad-spectrum protection against several common feline parasites. It is effective against fleas, ticks (black-legged or deer tick, Gulf Coast tick, and American dog tick), ear mites, roundworms, hookworms, and heartworms. This comprehensive protection helps safeguard your cat’s health in various environments.

Q10: Can I use Revolution Plus with other flea and tick medications?

Before using multiple flea and tick products simultaneously, consult with your veterinarian. While some medications can be safely used together, others might interact or lead to overdosing. It’s also important to consider whether multiple treatments are necessary, as Revolution Plus already provides broad-spectrum protection against many common parasites.

Q11: Can Revolution Plus be used in pregnant or lactating cats?

Revolution Plus has been demonstrated to be safe for use in pregnant and lactating cats according to product specifications. However, always consult with your veterinarian before starting or changing any medication regimen in pregnant or nursing cats, to ensure their safety and the safety of their kittens.

Q12: Can humans be affected by touching Revolution Plus?

After applying Revolution Plus, it’s important to avoid touching the treated area until it’s dry. The product could cause skin or eye irritation in humans. If the product gets into a human’s eyes, rinse thoroughly with water, and seek medical attention if irritation persists. Always wash your hands thoroughly after handling and applying the product.

Q13: Is Revolution Plus effective against indoor fleas?

Yes, Revolution Plus is effective against fleas, regardless of whether your cat is an indoor or outdoor pet. Fleas can make their way into homes on clothing, other pets, or even on humans themselves. Using a preventative like Revolution Plus ensures your indoor cat is protected against these pesky invaders.

Q14: What if my cat shows no improvement after using Revolution Plus?

While Revolution Plus is highly effective against many parasites, if your cat continues to scratch or show other signs of infestation after treatment, it may indicate that the pests are not susceptible to the medication, or there could be another underlying health issue. Consult your veterinarian who can conduct a thorough examination and possibly recommend a different course of treatment.

Q15: How does Revolution Plus work?

Revolution Plus is a topical medication that gets absorbed into the bloodstream through the skin. It contains two active ingredients: Selamectin and Sarolaner. Selamectin interferes with the nerve function of parasites, causing paralysis and death, while Sarolaner inhibits the nervous system of ticks and fleas. Together, these ingredients provide broad-spectrum protection against various parasites.

Q16: Can Revolution Plus be used on other animals?

No, Revolution Plus is specifically designed for use in cats. The medication’s formulation and dosing are based on feline physiology and weight, making it potentially dangerous if used on other animals. Always use pet medications as labeled, and consult your vet if you need a parasite prevention product for a different kind of pet.

Q17: Is Revolution Plus safe to use on a cat with a chronic illness?

It depends on the specific health condition of the cat. While Revolution Plus is generally safe for most cats, those with certain health conditions could potentially experience complications. Before starting any new medication regimen, you should discuss your cat’s complete health history with your vet, including any chronic illnesses or current medications.

Q18: Can Revolution Plus cause changes in a cat’s behavior?

In rare cases, cats might experience lethargy or other changes in behavior after the application of Revolution Plus. These effects are typically mild and temporary. However, if your cat exhibits significant behavioral changes or if these changes persist, it’s recommended to contact your vet to rule out any serious reactions.

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