⚠️ Can I Give My Dog Galliprant Twice a Day?

Galliprant, a popular medication for managing pain and inflammation in dogs with osteoarthritis, often raises questions about its correct dosage. One common query among pet owners is whether it’s safe to administer Galliprant twice a day.

What Is Galliprant?

🐾 Galliprant (grapiprant tablets) is a non-steroidal anti-inflammatory drug (NSAID) specifically designed for dogs. It’s used to treat pain and inflammation associated with osteoarthritis.

Understanding the Dosage

Recommended Dosage

The standard dosage of Galliprant is 2 mg/kg once daily. This dosage has been determined based on extensive clinical trials and is considered both effective and safe for dogs.

Can You Give Galliprant Twice a Day?

🚫 Generally, no. Galliprant is formulated to be effective with a once-daily dosage. Administering it twice a day can increase the risk of side effects and is not recommended unless specifically advised by a veterinarian.

Safety and Side Effects

Potential Side Effects

Like all NSAIDs, Galliprant can have side effects, although they are generally mild. These may include:

  • 🤢 Gastrointestinal upset
  • 🚱 Changes in drinking habits
  • 🍲 Changes in appetite
  • 🚽 Altered bowel movements

Overdose Risks

⚠️ Overdosing on Galliprant can lead to serious health issues. Symptoms of an overdose can include:

  • 😟 Lethargy
  • 🤮 Vomiting
  • 💧 Increased urination

Safety Profile of Galliprant

Factor Galliprant Safety Profile
Gastrointestinal Protection ✅ Good
Kidney Safety ✅ Generally Safe
Liver Safety ✅ Generally Safe
Overdose Risk ⚠️ Monitor Closely

When to Consult a Vet

👩‍⚕️ Always consult your veterinarian before starting Galliprant, particularly if your dog:

  • Is taking other medications
  • Has a history of liver or kidney disease
  • Is pregnant or nursing

Key Takeaways

Stick to Prescribed Dosage: The recommended dose of Galliprant is 2 mg/kg once daily. Doubling the dose can be harmful.

Monitor for Side Effects: Be vigilant about any changes in your dog’s behavior or health.

Consult Your Vet: Any concerns or questions about dosing should be directed to a professional.


In managing your dog’s osteoarthritis pain, it’s crucial to adhere to the recommended dosing guidelines for Galliprant. Overdosing can lead to adverse effects and compromise your pet’s health. Remember, your vet is your best resource for advice on managing your dog’s condition safely and effectively.

FAQs About Galliprant for Dogs

1. What Happens if I Miss a Dose of Galliprant?

If you miss a dose of Galliprant, give it as soon as you remember. However, if it’s almost time for the next dose, skip the missed dose and resume the regular schedule. Avoid giving two doses at once, as this can increase the risk of side effects.

2. Can Galliprant Be Used Alongside Other Medications?

Galliprant may interact with certain medications, including other NSAIDs and corticosteroids. Always inform your veterinarian about any other medications or supplements your dog is taking to avoid potential interactions.

3. Is Galliprant Safe for All Dogs?

Galliprant is generally safe for most dogs, but it may not be suitable for dogs with severe liver or kidney disease, or for dogs that are pregnant, breeding, or lactating. Always consult a veterinarian to ensure it’s safe for your specific dog.

4. How Quickly Does Galliprant Start Working?

Galliprant typically begins to alleviate symptoms within a few hours of administration. However, the full effect might take a couple of days. Consistency in dosing is key to maintaining its effectiveness.

5. Are There Any Breeds That Should Avoid Galliprant?

There is no breed-specific contraindication for Galliprant. However, individual sensitivities can vary. Monitoring for side effects is important for all dogs, regardless of breed.

6. Can Young Puppies Take Galliprant?

Galliprant is approved for use in dogs older than 9 months and weighing more than 8 pounds. It is not recommended for younger puppies due to their developing bodies and potential sensitivity to medications.

7. How Should Galliprant Be Stored?

Store Galliprant at room temperature, away from extreme heat, cold, and moisture. Keep the medication in its original packaging to protect it from light and moisture and to keep it out of reach of children and pets.

8. Does Galliprant Cure Osteoarthritis?

Galliprant is not a cure for osteoarthritis. It is used to manage symptoms such as pain and inflammation. Managing osteoarthritis often involves a combination of medication, dietary management, and in some cases, physical therapy.

9. What Should I Do If I Observe Side Effects in My Dog?

If you notice any side effects, such as changes in appetite, vomiting, diarrhea, or changes in behavior, contact your veterinarian immediately. They may adjust the dosage or suggest an alternative treatment plan.

10. Can Galliprant Be Used for Conditions Other Than Osteoarthritis?

While Galliprant is specifically approved for managing osteoarthritis pain and inflammation, veterinarians may use it off-label for other conditions that involve pain and inflammation. However, this should only be done under the guidance of a veterinarian.

11. Is Regular Monitoring Required While My Dog Is on Galliprant?

Regular veterinary check-ups are important for dogs on long-term medications like Galliprant. These check-ups often include blood tests to monitor liver and kidney function, ensuring the medication remains safe for your dog.

12. Are There Natural Alternatives to Galliprant?

Some pet owners seek natural alternatives like supplements containing glucosamine, chondroitin, or omega-3 fatty acids. While these can support joint health, they usually don’t replace the need for a prescription medication like Galliprant. Always discuss with your vet before starting any new supplement.

13. How Long Can a Dog Stay on Galliprant?

Dogs can remain on Galliprant for extended periods, even lifelong, if it effectively manages their symptoms without significant side effects. Ongoing veterinary supervision is crucial for long-term use.

14. What is the Mechanism of Action of Galliprant in Dogs?

Galliprant functions by specifically targeting and inhibiting the EP4 receptor, which plays a key role in mediating pain and inflammation associated with osteoarthritis. This targeted action helps in reducing discomfort while minimizing the impact on other bodily functions, such as kidney and gastrointestinal health.

15. Can Galliprant Be Used in Conjunction with Joint Supplements?

In many cases, Galliprant can be safely used alongside joint supplements like glucosamine or chondroitin. These supplements are often employed to support joint health. However, it’s important to consult with your veterinarian for the appropriate combination and dosage.

16. How Does Galliprant Differ From Traditional NSAIDs?

Unlike traditional NSAIDs that inhibit COX enzymes and can affect gastrointestinal, kidney, and liver health, Galliprant’s selective action on the EP4 receptor reduces the risk of these side effects. This makes it a preferred option, especially for long-term management in dogs with osteoarthritis.

17. Is There a Specific Time of Day Best for Administering Galliprant?

Galliprant can be administered at any time of day, but it’s advisable to give it at the same time each day for consistency. Some owners prefer to give it during mealtime to reduce the risk of stomach upset.

18. What Should I Do If My Dog Vomits After Taking Galliprant?

If your dog vomits shortly after administering Galliprant, wait and observe. If the vomiting is a one-time occurrence, you may try giving the next dose with food. However, if vomiting persists, consult your veterinarian for advice.

19. Are There Any Specific Tests Recommended Before Starting Galliprant?

Before starting a course of Galliprant, veterinarians often recommend baseline blood tests, including liver and kidney function tests. This helps in assessing the suitability of Galliprant for your dog and establishes a health baseline for future monitoring.

20. How Does Body Weight Affect Galliprant Dosage?

Galliprant dosage is based on the dog’s body weight. It’s crucial to administer the correct dose corresponding to your dog’s weight to ensure efficacy and minimize risk. Regular weight checks are advisable to adjust the dose as needed.

21. Can Galliprant Affect a Dog’s Behavior or Mood?

While not common, some dogs may exhibit changes in behavior or mood on Galliprant. These can include lethargy or decreased activity levels. If you notice significant behavioral changes, discuss these with your vet.

22. Is Galliprant Suitable for Dogs with a History of Ulcers?

Due to its selective action, Galliprant is often considered safer than traditional NSAIDs for dogs with a history of ulcers. However, each case is unique, so a thorough veterinary assessment is necessary.

23. Can Diet Influence the Effectiveness of Galliprant?

While diet doesn’t directly influence the effectiveness of Galliprant, maintaining a balanced diet is crucial for overall health and can support the management of osteoarthritis. Diets rich in omega-3 fatty acids may offer additional anti-inflammatory benefits.

24. What Are the Signs That Galliprant is Working Effectively?

Effective Galliprant treatment typically results in improved mobility, reduced lameness, and a noticeable decrease in discomfort. Observing your dog’s daily activities and behavior can help gauge the medication’s effectiveness.

25. How to Transition From Another NSAID to Galliprant?

Transitioning from another NSAID to Galliprant should be done under veterinary guidance. Generally, a washout period is required to clear the previous NSAID from the dog’s system before starting Galliprant to avoid adverse interactions.

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