Clavamox 375 mg for Dogs

Clavamox is an amalgamation of two active ingredients, Amoxicillin Trihydrate and Clavulanate Potassium. Together, they wage war against a variety of bacterial infections in dogs and cats. It comes in different strengths, including the 375 mg variant that we are focusing on.

Amoxicillin, a penicillin-like antibiotic, effectively disrupts the formation of bacterial cell walls, leading to bacterial cell death. However, some bacteria produce an enzyme, beta-lactamase, which renders Amoxicillin ineffective. This is where Clavulanate Potassium comes into play. It blocks the effects of beta-lactamase, allowing Amoxicillin to perform its job unhindered.

What is Clavamox 375 mg Used for?

Clavamox 375 mg is employed in combating a variety of bacterial infections in dogs. These include:

  1. Skin infections: Caused by strains of Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., and E. coli.
  2. Periodontal infections: Bacteria like Pasteurella spp., Streptococcus spp., and Prevotella, which trigger oral and dental infections, can be treated with Clavamox.
  3. Urinary tract infections (UTIs): Clavamox is commonly prescribed for UTIs caused by E. coli and certain strains of Staphylococci.
  4. Respiratory tract infections: It’s effective against bacterial pathogens causing respiratory distress, including Bordetella bronchiseptica and Streptococcus spp.

Dosage and Administration

Clavamox 375 mg is generally administered orally. The standard recommended dosage is 6.25 mg per pound of your dog’s body weight, given twice daily. This dosage may vary depending on the nature and severity of the infection. Always follow your vet’s advice for administering Clavamox to ensure optimal results.

Side Effects and Precautions

Though Clavamox is generally safe, side effects can occur. Common symptoms include loss of appetite, diarrhea, nausea, and vomiting. More serious side effects can include allergic reactions, like skin rashes, breathing difficulties, or swelling of the face, lips, or tongue.

Dogs with a history of allergic reactions to penicillin or cephalosporins should avoid Clavamox. Additionally, it should be used cautiously in dogs with kidney or liver disease.

Clavamox and Nursing Dogs

While Clavamox is often prescribed to lactating dogs, its safety is not conclusively established. Limited research suggests it might not harm nursing puppies, but you should always consult with your vet if your nursing dog requires antibiotic treatment.

Cost-Efficiency: Generic Clavamox

You can also find generic versions of Clavamox, such as Amoxicillin Trihydrate and Clavulanate Potassium tablets, which often cost less while providing the same effectiveness. It’s crucial to consult with your vet before making a switch to ensure it’s safe and suitable for your pet.

Recognizing Clavamox Resistance

While Clavamox is generally effective, some bacterial strains may develop resistance to it over time. This is why it’s vital to complete the entire course of the antibiotic, even if your dog’s symptoms improve before the medication is finished. Incomplete antibiotic treatment can lead to the development of drug-resistant bacteria, which can be more challenging to manage.

Interactions with Other Medications

Clavamox can interact with other medications, possibly altering their effectiveness or causing adverse effects. For instance, it might interact with antacids, bacteriostatics (like chloramphenicol, erythromycin), or probenecid. Therefore, ensure to inform your veterinarian about any medications, vitamins, or supplements your dog is currently taking.

Clavamox Overdose: Symptoms and Actions

While Clavamox is relatively safe, an overdose can lead to serious health problems. Symptoms of an overdose can include muscle weakness, vomiting, diarrhea, increased urination, seizures, or even coma. If you suspect an overdose, seek veterinary attention immediately. Avoid trying to induce vomiting unless explicitly instructed by a veterinarian.

Clavamox Storage Guidelines

Proper storage of Clavamox ensures its effectiveness and safety. It should be stored in a cool, dry place, away from light and out of reach of children and pets. Clavamox chewable tablets should be kept in a tightly sealed container at room temperature.

Clavamox’s Impact on Dog’s Behavior

Owners often notice changes in their dogs’ behavior when they start a new medication. Clavamox can, in some instances, cause dogs to behave differently. A common observation is lethargy or mild sedation post-administration, although this should only be temporary. If your dog appears persistently out of sorts, it might be a good idea to consult with your veterinarian.

Special Considerations for Clavamox Use

While Clavamox can be administered to dogs of all ages, puppies and senior dogs may need adjusted dosages and more careful monitoring. Similarly, dogs with underlying conditions like liver or kidney disease may require different doses or alternative medications. Always discuss these factors with your vet to ensure safe and effective use of Clavamox.


Can Clavamox cause changes in stool or urine?

Yes, Clavamox can occasionally lead to changes in your dog’s stool or urine. Some dogs may experience diarrhea as a side effect. Similarly, a change in urine color or frequency may occur. However, these symptoms should not persist. If they do, it’s crucial to consult with your vet.

What should I do if my dog vomits after taking Clavamox?

If your dog vomits shortly after taking Clavamox, you might question whether to give another dose. It’s recommended to wait until the next regularly scheduled dose. However, if your dog persistently vomits after taking the medication, consult with your veterinarian.

How long does Clavamox take to work?

The time it takes for Clavamox to start showing effects can vary depending on the type and severity of the infection. Generally, improvements can be seen within a few days. However, it’s essential to continue the prescribed course even if your dog seems to have recovered.

Can I give my dog Clavamox with food?

Yes, Clavamox can be given with food. In fact, administering Clavamox with food can help reduce gastrointestinal side effects such as nausea or vomiting. However, it’s best to follow the specific instructions given by your vet.

What if I miss a dose of Clavamox?

If you miss giving a dose of Clavamox, give it as soon as you remember. If it’s close to the time for the next dose, skip the missed dose and resume the regular schedule. Avoid giving your dog two doses at once.

Can I use Clavamox past its expiration date?

No, expired Clavamox should not be used. The efficacy of the drug decreases after the expiration date, and it may not be safe. Always check the expiration date before administering any medication and dispose of expired drugs properly.

Can I stop giving Clavamox if my dog feels better?

No, it’s crucial to finish the entire course of Clavamox, even if your dog appears to be better. Stopping the medication prematurely can result in the infection returning or the bacteria becoming resistant to the drug. Always follow your vet’s instructions regarding the length of treatment.

Can Clavamox cause an allergic reaction in my dog?

Yes, like any medication, Clavamox can cause allergic reactions in some dogs. Signs can include hives, difficulty breathing, swelling of the face, lips, tongue, or throat. If you notice any of these symptoms, stop the medication and contact your vet immediately.

Is there a difference between human and veterinary Clavamox?

While the active ingredients in human and veterinary Clavamox are the same, the formulations can differ. Human formulations may contain additives that are not safe for dogs. It’s crucial never to give your dog human medication without consulting with your vet.

What should I do if my dog doesn’t like the taste of Clavamox?

If your dog refuses to take Clavamox due to its taste, you can try hiding the medication in a treat or a small amount of food. Clavamox tablets are also available in a chewable form that many dogs find more palatable. Consult with your vet for more tips on administering medication to a picky dog.

Can Clavamox cause dehydration in dogs?

While Clavamox does not directly cause dehydration, some of its potential side effects, such as vomiting or diarrhea, can lead to dehydration. It’s essential to provide your dog with plenty of fresh water, especially when it’s on medication. If your dog exhibits signs of severe dehydration, like sunken eyes or lethargy, contact your vet immediately.

Can Clavamox be used in pregnant or lactating dogs?

Clavamox can be used in pregnant or lactating dogs if the vet deems it necessary. However, there is limited data on the potential risks it may pose to developing puppies. Your vet will consider this aspect before prescribing Clavamox to a pregnant or lactating dog.

Does Clavamox make dogs sleepy?

Some dogs might seem more tired or lethargic when they begin a course of Clavamox. This is generally not a cause for concern unless the lethargy is extreme or persists for a prolonged period. If you notice significant changes in your dog’s energy levels, contact your vet.

How should I dispose of unused Clavamox?

Unused or expired Clavamox should not be simply thrown in the trash, toilet, or sink. Improper disposal can harm the environment and potentially be harmful if ingested by wildlife. Most pharmacies offer take-back programs for safe disposal of medications. Always check with your local pharmacy or vet for proper medication disposal guidelines.

What happens if my dog eats more Clavamox than prescribed?

Overdosing on Clavamox can lead to serious health problems, including nausea, vomiting, diarrhea, drowsiness, hyperactivity, or kidney damage. If you suspect your dog has ingested more Clavamox than prescribed, contact your vet or an emergency animal clinic immediately.

Can Clavamox be given alongside other antibiotics?

While it’s technically possible to give Clavamox along with other antibiotics, this should only be done under the supervision of a vet. Some antibiotics can interact with each other, potentially causing adverse effects or reducing the effectiveness of the medications.

Can I give Clavamox to my dog for a cough?

While Clavamox can be effective in treating bacterial infections that could cause a cough, it should only be administered under a vet’s guidance. Not all coughs are due to bacterial infections, and using Clavamox unnecessarily can contribute to antibiotic resistance. If your dog has a persistent cough, it’s best to consult with your vet.

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