🐾 Galliprant Side Effects in Dogs: Everything You Need to Know

Published on: December 5, 2024December 5, 2024Author: Bestie Paws

If your dog is suffering from osteoarthritis or joint pain, Galliprant is one of the more popular medications that veterinarians prescribe to relieve their discomfort. Known for its targeted action and fewer gastrointestinal side effects compared to traditional NSAIDs, Galliprant is generally considered a safer option for long-term use. However, like all medications, it comes with potential side effects that pet owners need to be aware of. This comprehensive guide covers all the Galliprant side effects you might encounter, and how to manage them if they arise.

🔑 Key Takeaways: Quick Answers About Galliprant Side Effects 🐕

What are the common side effects? The most common include vomiting, diarrhea, and loss of appetite.
Are there serious side effects? Rarely, but serious effects like neurological symptoms or kidney dysfunction may occur.
How long do side effects last? Mild side effects often resolve in a few days, but more serious reactions should be reported to your vet immediately.
Can Galliprant cause lethargy? Yes, lethargy is a possible side effect and should be monitored closely.
Is Galliprant safer than other NSAIDs? It’s considered safer due to its selective action, but it still requires regular vet monitoring.

Now, let’s break down the most important details about Galliprant’s side effects so you can ensure your dog stays safe and healthy while receiving the benefits of arthritis pain relief.

💉 What Are the Most Common Side Effects of Galliprant?

The majority of dogs tolerate Galliprant well, but the most common side effects are gastrointestinal in nature. These include:

Vomiting: Some dogs may experience vomiting, especially during the first few doses as their system adjusts to the medication.
Diarrhea: Mild diarrhea is another common issue, but it often resolves after the first few days of treatment.
Decreased Appetite: A loss of interest in food may occur as a side effect. Monitor your dog’s eating habits, and ensure they stay hydrated.

These side effects are usually mild and tend to subside once your dog’s system adjusts to the medication. However, if they persist or worsen, it’s essential to consult your veterinarian.

💡 Pro Tip: To reduce the risk of stomach upset, try giving Galliprant with a small meal. This can help ease any gastrointestinal discomfort while maintaining the drug’s efficacy.

Side Effect	What to Watch For	💡 Tip
Vomiting	Episodes of throwing up, especially after meals	Try giving Galliprant with food to reduce nausea
Diarrhea	Frequent or loose stools	Monitor hydration and consider bland food if diarrhea persists
Loss of Appetite	Refusing food, decreased interest in meals	Offer smaller, more frequent meals to encourage eating

🧠 Can Galliprant Cause Neurological Side Effects?

Neurological side effects are rare but can occur in some dogs. These may include:

Lethargy: A lack of energy or excessive sleepiness can be a sign that Galliprant is affecting your dog’s nervous system. This should be monitored closely.
Disorientation or Ataxia: Some dogs may appear off-balance or confused. This can range from mild stumbling to more severe loss of coordination.
Seizures: In very rare cases, Galliprant has been linked to seizure activity, especially in dogs with pre-existing conditions.

If you notice any of these signs, contact your vet immediately to discuss whether Galliprant is the right fit for your dog or if the dosage needs adjustment.

💡 Pro Tip: Keep a daily log of your dog’s behavior, especially during the first few weeks of treatment. This can help identify any subtle changes that might indicate a neurological side effect.

Neurological Symptom	What to Watch For	💡 Tip
Lethargy	Unusual tiredness or lack of energy	Note changes in activity levels, especially after doses
Ataxia	Stumbling or loss of balance	If balance issues arise, contact your vet immediately
Seizures	Sudden shaking or loss of control	Seek emergency veterinary care if seizures occur

💊 How Serious Are Galliprant’s Gastrointestinal Side Effects?

Although Galliprant is designed to be gentler on the stomach than traditional NSAIDs, some dogs still experience gastrointestinal issues, particularly in the early stages of treatment. These are generally mild, but they can become more serious if left unchecked.

Severe Diarrhea or Vomiting: If vomiting or diarrhea persists beyond a couple of days or becomes severe, it could lead to dehydration or weight loss. In this case, consult your vet to determine whether to adjust the dosage or switch medications.
Stomach Ulcers: While rare, stomach ulcers are possible if your dog has underlying conditions or if Galliprant is used alongside other medications like corticosteroids. Symptoms of ulcers include blood in vomit or black stools, which require immediate veterinary attention.

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💡 Pro Tip: If your dog is prone to gastrointestinal issues, your vet may recommend pairing Galliprant with a stomach protector like famotidine or omeprazole to further reduce irritation.

Gastrointestinal Symptom	What to Watch For	💡 Tip
Severe Diarrhea	Persistent or bloody diarrhea	Monitor stools and ensure proper hydration
Vomiting	Chronic vomiting, especially with blood	Discontinue use and contact your vet immediately
Black Stools	Signs of stomach ulcers or internal bleeding	Seek emergency care if black or tarry stools appear

🩺 Can Galliprant Affect Your Dog’s Kidneys?

Galliprant is considered safer for the kidneys than other NSAIDs because it doesn’t inhibit COX-1, which is important for maintaining kidney function. However, dogs with pre-existing kidney conditions should still be monitored closely, as any long-term use of anti-inflammatory drugs can potentially affect the kidneys over time.

Your vet may recommend regular bloodwork to monitor kidney function if your dog is on Galliprant long-term. This is especially important for older dogs or those with a history of kidney disease.

💡 Pro Tip: Ask your vet about scheduling routine blood tests to check your dog’s kidney health. Early detection of any issues allows for timely adjustments to treatment.

Kidney Impact	What to Watch For	💡 Tip
Increased Thirst	Signs of kidney strain, including frequent drinking	Monitor your dog’s water intake and urination habits
Frequent Urination	Increased urination, accidents in the house	Contact your vet for kidney function tests if urination patterns change
Lethargy	Reduced energy, potential sign of kidney issues	Ensure blood tests are conducted regularly if Galliprant is used long-term

🗝️ Key Takeaways for Galliprant Side Effects:

Common side effects include vomiting, diarrhea, and loss of appetite, which are typically mild and resolve over time.
Neurological symptoms, though rare, such as lethargy, ataxia, and seizures, require immediate veterinary attention.
Galliprant is gentler on the kidneys and stomach than traditional NSAIDs but still necessitates regular monitoring for long-term use.
Monitor for signs of gastrointestinal distress and consult your vet if severe symptoms like bloody stools or persistent vomiting occur.

By staying informed and vigilant, you can ensure that your dog gets the pain relief they need from Galliprant while minimizing the risk of side effects. 🐕

❓ Comment: “What should I do if my dog vomits after taking Galliprant?”

If your dog vomits after taking Galliprant, the first step is to determine whether this is an isolated reaction or if it continues after each dose. Vomiting is one of the most common side effects, especially in the early stages of treatment, as your dog’s system adjusts to the medication. In most cases, this symptom is mild and may resolve on its own within a few days.

Here’s what you can do:

Monitor the vomiting frequency: If it happens only once or twice, try giving Galliprant with a small meal to reduce stomach irritation.
Watch for additional symptoms: If vomiting is accompanied by diarrhea or lethargy, it could be a sign that your dog is not tolerating the medication well.
Contact your vet: If the vomiting persists, worsens, or your dog is showing signs of dehydration (dry gums, lethargy, or sunken eyes), consult your vet immediately. They may adjust the dosage or recommend a different medication.

💡 Pro Tip: Offering bland food, such as boiled chicken and rice, can help soothe your dog’s stomach during the adjustment period.

❓ Comment: “My dog seems lethargic after starting Galliprant. Should I be worried?”

Lethargy can be a side effect of Galliprant, but whether or not it’s a cause for concern depends on the severity and duration of your dog’s tiredness. Some mild lethargy may occur as your dog adjusts to the medication, especially during the first few days of treatment. However, if your dog is excessively sleepy, unwilling to move, or showing a dramatic reduction in energy, it’s time to investigate further.

Here’s what to look for:

Monitor the timing: Does your dog become lethargic immediately after taking Galliprant, or does the drowsiness persist throughout the day?
Check for additional symptoms: Is your dog also showing signs of disorientation, stumbling, or loss of appetite? These symptoms, combined with lethargy, may indicate a more serious reaction.
Consult your vet: If lethargy persists for more than a day or two, or if it worsens, reach out to your vet. They may recommend lowering the dosage or switching to a different arthritis medication.

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💡 Pro Tip: Keep a daily log of your dog’s energy levels, including how they respond to each dose of Galliprant. This information will be valuable for your vet when assessing any potential side effects.

❓ Comment: “Can Galliprant cause kidney problems, and what signs should I watch for?”

While Galliprant is generally considered safer for the kidneys than traditional NSAIDs, it’s still important to monitor your dog, especially if they have pre-existing kidney conditions. Long-term use of any anti-inflammatory drug can affect kidney function in some dogs, so regular vet check-ups are essential to ensure your pet’s health.

Signs of kidney problems include:

Increased thirst: If your dog is drinking more water than usual, this could indicate kidney strain.
Frequent urination: Increased urination or accidents in the house can be a sign that the kidneys are working harder than they should.
Lethargy and weakness: A dog with kidney issues may appear tired or weak due to the body’s inability to properly filter waste.
Loss of appetite: Kidney dysfunction can affect your dog’s appetite, leading to weight loss or refusal to eat.

💡 Pro Tip: If your dog is on Galliprant long-term, ask your vet about conducting routine blood tests to monitor kidney and liver function. Early detection of kidney issues allows for timely adjustments to the medication.

❓ Comment: “What should I do if my dog experiences severe diarrhea while on Galliprant?”

Severe diarrhea is a more serious side effect of Galliprant that requires immediate attention, particularly if it’s persistent or accompanied by symptoms like vomiting or lethargy. Diarrhea can quickly lead to dehydration, especially in smaller or older dogs, so it’s important to address it promptly.

Here’s how to handle it:

Discontinue the medication temporarily: If your dog’s diarrhea is severe, stop administering Galliprant and contact your vet right away.
Hydrate your dog: Ensure your dog has access to plenty of fresh water to prevent dehydration. You can also offer electrolyte solutions (ask your vet for recommendations) to help replace lost fluids.
Switch to a bland diet: Feed your dog boiled chicken and plain rice to help settle their stomach while you wait for veterinary guidance.

💡 Pro Tip: If your vet suspects that Galliprant is the cause of the diarrhea, they may suggest switching to a different pain management option, such as Gabapentin or Adequan injections, which don’t typically cause gastrointestinal upset.

❓ Comment: “Are Galliprant side effects more common in older dogs?”

Older dogs can be more sensitive to medications in general, and while Galliprant is designed to be safer than traditional NSAIDs, side effects may still be more pronounced in senior dogs. Age-related conditions, such as decreased kidney or liver function, can make it harder for an older dog’s body to process medications, increasing the risk of side effects.

Some things to monitor in older dogs:

Lethargy: Older dogs may already have lower energy levels, so it can be harder to distinguish between normal aging and drug-induced lethargy. Pay close attention to any sudden changes in behavior.
Gastrointestinal issues: Senior dogs may be more prone to vomiting, diarrhea, or loss of appetite while adjusting to Galliprant. It’s important to monitor their hydration and ensure they are eating enough to maintain a healthy weight.
Kidney function: As older dogs are more likely to have compromised kidney function, regular blood tests to monitor their kidney health are recommended during Galliprant use.

💡 Pro Tip: When treating senior dogs, start with the lowest effective dose of Galliprant and work closely with your vet to monitor for any signs of side effects. Adjusting the dosage based on your dog’s response can help minimize risks.

❓ Comment: “My dog seems to have lost interest in food after starting Galliprant. Is this normal, and what should I do?”

A loss of appetite is a relatively common side effect of Galliprant, especially in the first few days of treatment. This can happen as your dog’s body adjusts to the medication, and while it’s usually temporary, it’s important to ensure your dog is still eating enough to maintain proper nutrition.

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Here’s how you can manage it:

Encourage small, frequent meals: If your dog isn’t interested in their regular food, try offering smaller, more frequent portions throughout the day. You can also try warming up the food slightly to enhance its aroma and make it more appealing.
Switch to bland food: If the appetite loss is accompanied by stomach upset, consider switching to bland, easy-to-digest foods like boiled chicken and white rice until their stomach settles.
Monitor hydration: Even if your dog isn’t eating much, make sure they are still drinking water to avoid dehydration, which can complicate the situation.

💡 Pro Tip: If your dog’s appetite doesn’t improve after a few days, or if they’re losing weight, consult your vet. They may adjust the dosage or suggest adding a probiotic to soothe your dog’s digestive system.

❓ Comment: “Is it safe to give Galliprant to a dog with a sensitive stomach? My dog has had GI issues in the past.”

Galliprant is generally safer for dogs with sensitive stomachs compared to traditional NSAIDs like Carprofen or Meloxicam because it has a more targeted action and does not inhibit COX-1, an enzyme that protects the gastrointestinal tract. However, while it’s designed to minimize GI side effects, some dogs with a history of gastrointestinal issues may still experience vomiting, diarrhea, or loss of appetite.

If your dog has had GI issues in the past, here’s what you can do to reduce the risk of a flare-up:

Give Galliprant with food: Administering Galliprant alongside a small meal can help buffer the stomach and reduce irritation.
Watch for early signs: Keep an eye out for the first signs of GI distress, such as loose stools or nausea. Acting quickly can prevent more severe symptoms.
Consult your vet: If your dog has a history of ulcers or severe GI problems, talk to your vet about whether adding a stomach protector like famotidine (Pepcid) is necessary.

💡 Pro Tip: Introducing a probiotic supplement alongside Galliprant can support your dog’s digestive health and help maintain a balanced gut microbiome, which may reduce the chances of GI upset.

❓ Comment: “Can I give my dog Galliprant if they’re already taking other medications for pain or inflammation?”

Combining medications with Galliprant should always be done with caution, and it’s essential to consult your vet before adding or adjusting any treatments. While Galliprant is often used as an NSAID alternative, it should not be given alongside other NSAIDs (like Carprofen, Rimadyl, or Meloxicam) as this can increase the risk of gastrointestinal damage and kidney issues.

However, Galliprant can sometimes be safely combined with other medications for chronic pain management, such as:

Gabapentin: Used to treat nerve pain or as a supplement to NSAID therapy for dogs with arthritis.
Tramadol: A mild opioid pain reliever that can work alongside Galliprant for dogs requiring extra pain control.
Adequan: Injectable joint support therapy that promotes cartilage repair and can be used with Galliprant for long-term arthritis management.

💡 Pro Tip: Always provide your vet with a full list of your dog’s medications and supplements to ensure there are no harmful drug interactions. Your vet can also help create a comprehensive pain management plan that includes Galliprant and other supportive therapies.

❓ Comment: “How long can my dog safely stay on Galliprant? Is it okay for long-term use?”

Galliprant is specifically formulated to be a safer option for long-term management of osteoarthritis and joint pain, especially for dogs that need daily relief without the gastrointestinal or renal risks associated with traditional NSAIDs. Because it selectively targets the EP4 receptor, responsible for pain and inflammation, without affecting COX-1 enzymes that protect the stomach and kidneys, it’s considered a good choice for chronic pain management.

However, long-term use of Galliprant still requires monitoring, particularly for:

Kidney function: Although Galliprant is less likely to cause kidney issues, regular blood tests to check kidney and liver function are recommended, especially for older dogs.
Effectiveness: Over time, your dog’s pain management needs may change, and their response to Galliprant may need to be reassessed.

💡 Pro Tip: If your dog is on Galliprant long-term, schedule biannual vet check-ups to ensure the medication is still working effectively and to catch any potential side effects early. Adjusting the dose or incorporating other treatments, like physical therapy or joint supplements, can enhance long-term care.

❓ Comment: “Are there any supplements I can give alongside Galliprant to support joint health and reduce side effects?”

Yes! Adding joint supplements alongside Galliprant can enhance your dog’s mobility and overall joint health while reducing the need for higher doses of medication. Common supplements that work well with Galliprant include:

Glucosamine and Chondroitin: These popular joint supplements help rebuild cartilage and improve joint lubrication, which can be particularly helpful for dogs with arthritis.
Omega-3 Fatty Acids: Found in fish oil, omega-3s have anti-inflammatory properties that support joint health and may even reduce the need for higher doses of pain medication. Look for high-quality EPA/DHA fish oil supplements.
Green-Lipped Mussel (GLM): A potent natural anti-inflammatory, GLM is known for supporting joint health and is often included in high-quality joint supplement formulations.

💡 Pro Tip: Always consult your vet before adding any supplements to your dog’s regimen, especially if they’re already on medication like Galliprant. Supplements can take several weeks to show benefits, so consistency is key for long-term improvements.