Isoxazoline Brands

With pet ownership on the rise, it’s more essential than ever to understand the available treatments for common pests such as fleas and ticks. Among the most recent developments in veterinary care, isoxazoline stands out. But, what exactly are isoxazoline brands, and how do they work?

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FAQs on Isoxazoline Brands

What is Isoxazoline?

Isoxazoline is a class of drug used to prevent and treat flea and tick infestations in animals, particularly cats and dogs. It works by targeting the nervous systems of these pests, causing paralysis and eventual death, offering effective protection for pets.

FDA-Approved Isoxazoline Brands

Bravecto: Available in tablet form for dogs and topical solutions for both cats and dogs, containing the active ingredient fluralaner.

Credelio: A brand available as tablets for both dogs and cats, featuring lotilaner as the active ingredient.

Nexgard: Contains afoxolaner and is available in tablet form for dogs.

Simparica: A tablet for dogs with sarolaner as the chief ingredient.

Revolution Plus: This topical solution for cats merges selamectin and sarolaner for comprehensive protection.

Several of these products also combine other agents to protect against additional parasites and conditions, such as ear mite infestations, gastrointestinal parasites, and heartworm disease.

Isoxazoline’s Neurologic Adverse Events

There have been reports of potential neurologic adverse events linked with some isoxazoline products. The FDA has been proactive in this, working with manufacturers to include label information that highlights such potential neurologic events.

Benefits of Using Isoxazoline Brands

Potent and Long-Lasting: These products generally offer a month’s protection against pests, with some lasting even longer.

Broad Spectrum: Not only do they act against fleas and ticks, but some also provide protection against other parasites.

Convenience: Offered in easy-to-administer forms like chewable tablets and topical solutions.

Potential Concerns

Pet owners have expressed concerns over possible side effects, including neurological reactions. It’s imperative to consult with a veterinarian before choosing a treatment option.

Alternatives to Isoxazoline

Given potential concerns, some pet owners seek alternatives. Traditional options include collars, sprays, and shampoos. However, effectiveness and duration may vary.


While isoxazoline brands offer effective flea and tick protection for pets, like any medication, they come with potential risks. It’s vital to be informed and consult with a veterinarian to determine the best option for your beloved pet.

FAQs on Isoxazoline Brands

1. How does isoxazoline work against fleas and ticks?

Isoxazoline targets the nervous systems of pests like fleas and ticks. By interfering with their nerve function, it induces paralysis, eventually leading to their death. This inhibits their ability to feed, reproduce, or thrive on your pet.

2. Are all pets suited for isoxazoline-based treatments?

Not all pets are ideal candidates. Puppies and kittens below a certain age, pregnant or lactating animals, and pets with a history of neurological disorders may require different treatments. It’s crucial to discuss with a veterinarian before administering.

3. What are the most common side effects reported?

While many pets tolerate isoxazoline products well, some side effects include vomiting, diarrhea, lethargy, decreased appetite, and, in rare cases, neurological signs such as tremors and seizures.

4. Can I use isoxazoline brands year-round?

Yes, many veterinarians recommend year-round protection, especially in regions with persistent flea and tick problems. Continuous use ensures that pets remain safeguarded against potential infestations.

5. Can I bathe my pet after applying a topical isoxazoline product?

It’s best to wait at least 48-72 hours after application before bathing your pet. This allows the product to disperse properly over your pet’s skin.

6. Are there drug interactions to be wary of?

While isoxazoline compounds have a broad safety margin, it’s always prudent to inform your vet about any other medications or treatments your pet is currently receiving.

7. How long does it take for these products to start working?

Most isoxazoline brands start working within hours. Fleas typically die within 12 hours of treatment, while ticks may take slightly longer, up to 48 hours in some cases.

8. What if I miss a dose?

If you forget a dose, administer the treatment as soon as you remember. After that, continue with the regular schedule as advised by the veterinarian. Maintaining consistent protection is key.

9. Are there any resistance issues with fleas and ticks to isoxazoline?

As of now, there’s limited evidence to suggest significant resistance development in fleas and ticks against isoxazoline. However, rotating treatments under a vet’s guidance can prevent potential resistance.

10. How should I store isoxazoline products?

Always store them in a cool, dry place away from direct sunlight. Ensure they’re kept out of reach from children and pets. Reading the product label for specific storage instructions is also advisable.

11. Why was there a warning about neurological effects related to isoxazoline?

In 2018, the FDA issued an alert after noting a few cases where pets showed signs of neurological issues, such as tremors, seizures, and muscle twitching, post administration of isoxazoline products. However, these incidents were rare and appeared more commonly in pets without a prior history of seizures.

12. Are there any natural alternatives to isoxazoline?

Yes, some pet owners opt for botanical treatments like lemon eucalyptus oil or cedarwood oil as repellents. However, their efficacy and duration might not match those of isoxazoline products. Consultation with a vet before trying any alternative is crucial.

13. Can I combine isoxazoline products with other flea and tick treatments?

Combining treatments might increase the risk of side effects. Always seek a veterinarian’s advice before layering or mixing products to ensure your pet’s safety.

14. Is there a specific time of year when fleas and ticks are most active?

Fleas and ticks are usually more active in warmer months. However, with changing global temperatures, some areas experience extended seasons, making year-round protection increasingly important.

15. How do I know if the product is working?

Post-treatment, you might observe more fleas on your pet as they rise to the fur’s surface before dying. Reduction in scratching and no new tick attachments are good indicators. However, to verify, a periodic check, especially in the fur’s dense areas, is recommended.

16. What should I do if my pet shows an adverse reaction?

Discontinue the product immediately and wash off any topical applications with mild soap and water. Contact your veterinarian promptly to discuss symptoms and seek advice.

17. Can I use canine isoxazoline products on cats, or vice versa?

Never interchange products between species. What’s safe for a dog might be lethal for a cat and vice versa. Always use products specifically formulated for the particular animal.

18. How are isoxazoline products administered?

Isoxazoline can be given orally in tablet form or applied topically. The mode of administration may vary based on the brand and your pet’s needs.

19. Are there any long-term studies on isoxazoline safety?

As with many newer products, long-term studies spanning several years might not be available. However, the initial trials and post-marketing surveillance have generally indicated that these products are safe when used as directed.

20. Can I administer isoxazoline to a pregnant or nursing pet?

Some isoxazoline products have not been tested extensively on pregnant or nursing animals. It’s imperative to consult with a vet for guidance on the safest choices during these life stages.

21. How do I store isoxazoline products safely?

Most isoxazoline products should be stored at room temperature, away from direct sunlight and out of reach from children and pets. Always check the product label for specific storage guidelines.

22. Are there any breed-specific reactions to isoxazoline?

Some breeds, especially herding breeds like Collies, might be more sensitive to certain medications due to a genetic mutation (MDR1). Always discuss breed-specific concerns with your veterinarian.

23. Can I use isoxazoline products on a puppy or kitten?

The age for initiation varies among products. Some can be started as early as eight weeks. However, always ensure you read the label and get guidance from your vet.

24. How does resistance develop, and is it a concern with isoxazoline?

Resistance can develop when parasites evolve to survive treatments. While there’s no widespread evidence of resistance to isoxazoline, rotating treatments and following label recommendations can help prevent it.

25. Can I bathe my pet after applying a topical isoxazoline solution?

It’s typically recommended to wait for at least 48-72 hours post-application before bathing your pet or allowing them to swim. This ensures optimal product absorption.

26. What’s the difference between ‘prevention’ and ‘treatment’ in context to these products?

“Prevention” means the product proactively keeps fleas and ticks from infesting your pet, while “treatment” implies the product can act against an existing infestation, killing the pests.

27. Are isoxazoline products effective against all tick species?

While these products are effective against multiple tick species, always check the label to see which specific ticks are covered and consult with your vet about local tick concerns.

28. What should I do if I miss a dose or treatment cycle?

If you miss a dose, administer the product as soon as you remember and adjust your schedule accordingly. Regular adherence maximizes effectiveness, so setting reminders can be beneficial.

29. Can isoxazoline products interact with other medications?

As with any medication, there’s potential for interactions. Always inform your veterinarian about all products and medications your pet is receiving.

30. Why do some pets continue to get ticks after using these products?

No product guarantees 100% efficacy. While ticks might attach, they typically die within 24-48 hours of contact with a treated pet, reducing the risk of disease transmission.

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