Revolution vs. NexGard for Dogs

When it comes to ensuring our furry friends are protected against fleas, ticks, and other pests, the choice of medication can be overwhelming. Two leading names in the industry, Revolution and NexGard, are often pitted against each other.

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Frequently Asked Questions (FAQs)

1. What Are Revolution and NexGard?

Revolution (Selamectin):

A topical medication applied monthly.

Protects against fleas, ear mites, and certain ticks. Also guards against heartworms and some internal parasites.

NexGard (Afoxolaner):

An oral chewable tablet given monthly.

Specifically designed to kill adult fleas and ticks, including those carrying Lyme disease.

2. Efficacy and Protection


Protects against a broader range of pests.

Prevents heartworm disease when given monthly.


Renowned for its fast-acting formula against fleas and ticks.

Does not offer protection against heartworms or internal parasites.

3. Side Effects: What Owners Need to Know


Generally well-tolerated.

Rare side effects may include temporary hair loss, upset stomach, or drooling.


Most dogs consume it readily without issues.

Potential side effects can include vomiting, diarrhea, and dry skin.

Always consult with your veterinarian if you notice any adverse reactions.

4. Convenience and Administration


Topical application; needs to be applied to the skin directly.

Ensure pets do not bathe or get wet immediately after application.


Oral chewable; many dogs find it palatable and treat-like.

No concerns about bathing or swimming after administration.

5. Cost Comparison

Prices for both medications may vary based on location, dosage, and where you purchase them. It’s always advisable to compare prices and consider the overall health needs of your dog.

6. Can You Use Revolution and NexGard Together?

It’s not uncommon for pet owners to consider combining treatments for broader protection. While there is no known dangerous interaction between Revolution and NexGard, it’s essential to consult with a veterinarian before administering both.

Conclusion: Which is Best for Your Dog?

The choice between Revolution and NexGard depends on your dog’s specific needs:

  • If you’re looking for broad-spectrum protection, including heartworm prevention, Revolution might be the way to go.
  • For those in areas with high flea and tick prevalence, and if heartworm prevention is covered elsewhere, NexGard could be the preferred choice.

Always remember, the best decision is an informed one. Schedule a chat with your local vet to discuss which option aligns best with your pet’s health needs.

Frequently Asked Questions (FAQs)

Q: What makes NexGard’s mechanism of action unique?

A: NexGard contains afoxolaner, an isoxazoline chemical, that targets the nervous systems of fleas and ticks, causing hyperexcitation and, eventually, their death. Its efficacy remains consistent throughout the entire month, providing long-lasting protection.

Q: Are there any specific breeds sensitive to Revolution or NexGard?

A: While both Revolution and NexGard are generally safe for all breeds, certain drugs in the isoxazoline class (like afoxolaner in NexGard) have been associated with adverse reactions in dogs with a history of seizures. Always discuss any breed-specific concerns with your veterinarian.

Q: How quickly do these medications start working after administration?

A: NexGard begins killing fleas approximately 4 hours after ingestion, and it achieves over 99% efficacy in 8 hours. Revolution, on the other hand, starts killing fleas within 36 hours of application.

Q: Is resistance to these medications a concern?

A: To date, there’s no widespread evidence of flea or tick resistance to either NexGard or Revolution. Nonetheless, rotating between different classes of preventatives annually can help reduce the chances of resistance developing.

Q: Can I administer these medications to pregnant or lactating dogs?

A: Revolution is approved for use in pregnant and lactating pets. NexGard, however, hasn’t been tested in pregnant or lactating dogs, so it’s crucial to consult with your vet before administration.

Q: How do environmental factors, like swimming or bathing, affect these treatments?

A: NexGard, being an oral treatment, is not affected by swimming or bathing. With Revolution, it’s recommended to avoid bathing or immersing your dog in water for at least two hours after application, although it remains effective even with occasional bathing.

Q: Do either of these medications protect against mites or mange?

A: Revolution is effective against ear mites (Otodectes cynotis) and sarcoptic mange (Sarcoptes scabiei). NexGard primarily targets fleas and ticks but has been found effective in treating certain types of mange.

Q: What should I do if I miss a dose?

A: If you miss a dose, administer the medication as soon as you remember and then continue with the regular schedule. Maintaining consistent protection is crucial to prevent potential infestations or infections.

Q: Are there any interactions with other commonly used pet medications?

A: There are no widely recognized drug interactions with either Revolution or NexGard. However, always inform your vet about all medications or supplements your pet is taking before starting a new treatment.

Q: Can puppies be treated with Revolution or NexGard?

A: Puppies as young as 6 weeks can be treated with Revolution. For NexGard, it’s safe to administer to puppies 8 weeks or older weighing 4 pounds or more.

Q: Can NexGard and Revolution be used concurrently for broader protection?

A: Combining treatments can provide more comprehensive protection. However, it’s essential to consult with a vet before administering multiple medications to avoid potential adverse effects or overdosage.

Q: Do climate or geographical conditions impact the effectiveness of Revolution or NexGard?

A: While both medications are effective regardless of climate, certain geographical areas have higher risks of specific pests. For instance, Lyme disease is more prevalent in northeastern regions, making tick protection vital. Always adapt preventative measures based on local parasitic risks.

Q: Are there any specific dietary concerns when administering NexGard?

A: NexGard can be given with or without food. Some owners find that giving it with a meal helps in easier ingestion, but there’s no dietary requirement for its effectiveness.

Q: What are the common side effects associated with these medications?

A: Most dogs tolerate both medications well. However, some might experience digestive upset, itching, or lethargy. Rare side effects include seizures, especially in dogs with a history of neurological issues. Monitoring your pet after administration is always a good practice.

Q: If a human accidentally ingests NexGard or comes into contact with Revolution, what should be done?

A: If ingested, seek medical attention immediately and show the product label or packaging to healthcare professionals. For topical contact, such as with Revolution, wash the area thoroughly with soap and water.

Q: How are these medications stored safely, especially around children and other pets?

A: Store both Revolution and NexGard in a cool, dry place away from direct sunlight. Ensure they’re out of reach of children and pets, and always use the original packaging to avoid mix-ups.

Q: Can these medications be used for breeds with hereditary health conditions?

A: While generally safe, breeds with specific hereditary conditions might be more susceptible to certain side effects. For instance, Collies with the MDR1 mutation may react differently to some medications. Always discuss your dog’s breed and history with your vet.

Q: How do I transition safely from one medication to another?

A: When switching, it’s important to ensure continuous protection without overdosing. Wait until the current medication’s protection period ends before administering a new one. Consultation with a veterinarian ensures a seamless transition.

Q: Are there any natural alternatives to Revolution or NexGard?

A: There are natural repellents, like those containing lemon eucalyptus oil or apple cider vinegar. While some pet owners prefer these methods, their efficacy is often less consistent than pharmaceutical solutions. It’s crucial to weigh natural benefits against potential risks of infestation or disease.

Q: Can older dogs with chronic illnesses be treated with these medications?

A: Age or chronic conditions don’t necessarily preclude the use of Revolution or NexGard. However, it’s essential to discuss your older dog’s overall health and concurrent medications with your vet to ensure safe administration.

Q: Can pregnant or nursing dogs use NexGard or Revolution?

A: Revolution has been tested safe for use in pregnant and nursing dogs. NexGard, however, hasn’t undergone specific testing for this demographic. Always communicate with a vet before administering any medication to pregnant or nursing pets.

Q: How do NexGard and Revolution interact with other medications?

A: Generally, these treatments have no known harmful interactions with other commonly prescribed pet medications. However, always provide a full list of treatments your dog receives to your vet before starting a new preventive.

Q: What happens if a dose is missed?

A: Missing a dose can leave your dog vulnerable to pests. If a dose is skipped, administer the treatment as soon as remembered and adjust the subsequent schedule accordingly. Maintain monthly applications for consistent protection.

Q: Are there breed-specific concerns when using these treatments?

A: While both drugs are generally safe for all breeds, certain breeds with known sensitivities, like Collies, might require monitoring or dose adjustments. Discuss any breed-specific concerns with your veterinarian.

Q: Can puppies be treated with NexGard or Revolution?

A: Puppies as young as eight weeks can be treated with NexGard. Revolution is approved for puppies starting at six weeks. Always ensure the correct dosage based on weight and age.

Q: How does the body metabolize these treatments, and are there long-term impacts?

A: Both drugs are designed for efficient metabolism by dogs, primarily processed by the liver and excreted through feces and urine. There’s no evidence of detrimental long-term effects when used as directed.

Q: Can these treatments be used for dogs with skin conditions?

A: While Revolution is a topical treatment, it’s typically safe for dogs with skin conditions. NexGard, being oral, avoids skin altogether. However, if your dog has a skin condition, always discuss any potential irritations or interactions with your vet.

Q: In cases of severe infestations, are multiple treatments necessary?

A: Severe infestations may require an integrated approach. Alongside regular dosages of Revolution or NexGard, environmental treatments and additional medications might be recommended. Consult a vet for a comprehensive plan.

Q: Are there contraindications for using these treatments in dogs with liver or kidney disease?

A: Dogs with liver or kidney disease may process medications differently. Before administering Revolution or NexGard to a dog with these conditions, ensure you receive clearance and guidance from a vet.

Q: What should owners do if they notice adverse reactions post-administration?

A: If signs of an allergic reaction, such as swelling, hives, vomiting, or unusual behavior, are observed, consult a vet immediately. Documenting and communicating any adverse reactions can assist in finding a more suitable treatment option.

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