Non-steroidal anti-inflammatory drugs (NSAIDs) are a commonly prescribed class of medications used to manage pain and inflammation in dogs. One such NSAID is Galliprant, which is used to treat osteoarthritis in dogs. However, as with any medication, there are potential side effects that should be considered before administering it to your pet. One of the concerns with NSAIDs is their potential effect on the liver.
The liver is a vital organ that plays a crucial role in detoxifying the body and maintaining overall health. When the liver is not functioning properly, it can lead to a wide range of health problems. Therefore, it is important to understand the potential effects of any medication on the liver, including Galliprant.
Research has shown that NSAIDs can cause mild changes in liver enzymes, characterized primarily by increases in liver enzymes without clinical signs or hepatic dysfunction. This is known as “hepatic dysfunction” and is a common side effect of NSAIDs. However, it is important to note that these changes are typically mild and reversible, and do not necessarily indicate that the liver is being damaged.
In the case of Galliprant, studies have shown that this medication does not have a significant effect on liver enzymes. In a study involving healthy dogs, Galliprant was found to have no significant effect on liver enzymes or other indicators of liver function. Similarly, in a study involving dogs with osteoarthritis, Galliprant was found to have no significant effect on liver enzymes or other indicators of liver function.
Galliprant also has potential nephrotoxicity effects. Nephrotoxicity is a condition in which the kidneys are damaged or impaired. This can lead to a variety of problems, such as decreased urine output, increased urine protein, and even kidney failure. Therefore, it’s important to be aware of this potential side effect, especially in dogs with pre-existing kidney disease or chronic kidney disease (CKD).
In conclusion, while NSAIDs can have potential effects on the liver, Galliprant appears to have no significant effect on liver enzymes or other indicators of liver function in healthy dogs. However, this medication may cause nephrotoxicity, especially in dogs with pre-existing kidney disease or CKD. If your dog is suffering from osteoarthritis and you’re considering starting them on Galliprant, it’s important to consult with your veterinarian to weigh the potential benefits and risks of this medication for your pet. Your veterinarian will also be able to provide you with information on alternative treatments that may be more appropriate for your dog.