Does Galliprant Affect the Liver or Kidneys in Dogs?

With age, arthritis becomes a common concern among our canine companions, necessitating a close look at pain management options. Among several medications available for controlling canine osteoarthritis, Galliprant (Grapiprant) has emerged as a popular choice. But as a responsible pet parent, you may ask, does Galliprant affect the liver or kidneys?

Understanding Galliprant

Galliprant is a non-steroidal anti-inflammatory drug (NSAID) that works differently from traditional NSAIDs. It is specifically designed to target and block the prostaglandin E2 (EP4) receptor, which plays a significant role in the generation of pain and inflammation associated with osteoarthritis. Its targeted action allows it to provide relief while minimizing the impact on other physiological processes.

Galliprant and Kidney Health

Kidney damage is a legitimate concern with long-term use of many NSAIDs. These drugs can interfere with the production of compounds essential for maintaining blood flow to the kidneys. So, how does Galliprant fare on this front?

Interestingly, Galliprant is celebrated for its comparatively lower impact on kidney health, especially for chronic use. Unlike traditional NSAIDs, Galliprant’s focused action on EP4 receptors curtails its effects on renal blood flow, hence potentially posing less risk to kidney function.

However, this doesn’t exempt Galliprant from all concerns. Like any medication, Galliprant should be administered responsibly, with regular veterinary check-ups to monitor kidney function over time.

Galliprant and Liver Health

The liver is a critical organ in drug metabolism, and its health is vital for overall systemic function. Again, traditional NSAIDs have been linked to potential hepatotoxicity with long-term use.

Galliprant, however, is reported to have a lesser impact on liver function compared to many of its counterparts. Its selectivity for the EP4 receptor largely confines its action to managing pain and inflammation, thereby reducing widespread systemic effects.

That said, while Galliprant may pose less risk to liver health, it’s always vital to monitor liver enzymes during its use. Regular veterinary assessments will ensure that any potential negative impacts are caught early and managed effectively.

A Balanced View: Galliprant’s Safety Profile

Clinical trials and anecdotal evidence suggest that Galliprant has a good safety profile and is generally well-tolerated in dogs. Yet, it’s important to remember that each dog is an individual, and reactions can vary.

While Galliprant can offer effective pain relief with reduced impact on kidney and liver health, potential side effects (like vomiting, diarrhea, decreased appetite) may still occur. Its use should always be under the guidance of a professional vet, factoring in the dog’s overall health, age, and concurrent medications.


To answer the question, “Does Galliprant affect the liver or kidneys?”, it seems that Galliprant presents a lesser risk compared to some traditional NSAIDs. However, a lesser risk does not mean no risk, emphasizing the importance of regular monitoring and veterinary guidance when using this medication.

FAQs: Galliprant and Canine Health

1. What is the appropriate dosage of Galliprant for my dog?

The dosage of Galliprant can vary based on your dog’s weight and the discretion of the vet. The general recommended dosage is 0.9 mg/lb (2 mg/kg) once a day. However, it’s critical not to adjust the dosage or frequency without your vet’s approval.

2. Are there any side effects I should watch for while my dog is on Galliprant?

While Galliprant is generally well-tolerated, some dogs might experience side effects such as vomiting, diarrhea, decreased appetite, or lethargy. In rare cases, it may also lead to abnormal blood work results. If you notice any unusual symptoms in your pet, consult your vet immediately.

3. Can Galliprant be used with other medications?

Galliprant can interact with some medications, such as corticosteroids, other NSAIDs, and ACE inhibitors, among others. Always inform your vet about all medications and supplements your dog is currently taking to avoid potential interactions.

4. Is Galliprant suitable for long-term use?

Galliprant is designed for the long-term management of pain and inflammation associated with osteoarthritis in dogs. Its targeted action on the EP4 receptor minimizes the risk to kidney and liver health compared to traditional NSAIDs, making it a viable choice for chronic use. Nonetheless, regular veterinary monitoring is necessary to ensure ongoing health.

5. How quickly does Galliprant start working?

Galliprant starts to work soon after administration, with the relief of pain and inflammation observed within a few hours. However, for the management of chronic conditions like osteoarthritis, consistent, daily use as prescribed by your vet is crucial for optimal results.

6. Can Galliprant be used in all dogs?

Galliprant is generally safe for use in dogs older than 9 months and weighing more than 8 pounds. However, it’s not recommended for dogs who are breeding, pregnant, or lactating. Dogs with pre-existing kidney disease, heart disease, or dehydration should use Galliprant only under strict veterinary supervision.

7. Can I administer Galliprant to my dog with food?

Yes, Galliprant can be given with or without food. However, administering it with food may help reduce the chances of gastrointestinal upset, a potential side effect of the medication.

8. Is Galliprant the same as other NSAIDs?

While Galliprant is a part of the Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) family, it differs in its working mechanism. Unlike traditional NSAIDs that inhibit COX enzymes and may impact the gastrointestinal, kidney, and liver functions, Galliprant specifically targets the EP4 receptor. This receptor is primarily responsible for pain and inflammation in osteoarthritis, leading to effective management with a lower risk of side effects.

9. What should I do if my dog misses a dose of Galliprant?

If your dog misses a dose, administer it as soon as you remember. However, if it’s close to the time for the next dose, skip the missed dose and return to the regular dosing schedule. Avoid doubling up on doses as it could lead to overdose symptoms like nausea, vomiting, and in severe cases, kidney or liver damage.

10. What happens if my dog accidentally ingests an overdose of Galliprant?

Overdosing on Galliprant can lead to serious health issues. Symptoms may include but are not limited to, vomiting, diarrhea, lethargy, and loss of appetite. If you suspect your pet has ingested an overdose, seek immediate veterinary attention.

11. How should I store Galliprant?

Store Galliprant at room temperature between 68°F to 77°F (20°C to 25°C). Keep it in a safe location out of the reach of children and pets to prevent accidental ingestion.

12. Can I use Galliprant for my cat?

Galliprant is specifically approved for use in dogs. It has not been studied in cats and is not recommended for use in felines without explicit veterinary guidance.

13. Can Galliprant cause weight changes in my dog?

While weight changes are not a common side effect of Galliprant, any significant change in your dog’s weight or eating habits while on medication should be discussed with your vet.

14. Is Galliprant a steroid?

No, Galliprant is not a steroid. It is a non-steroidal anti-inflammatory drug (NSAID) designed to treat pain and inflammation associated with osteoarthritis in dogs.

15. How should Galliprant be discontinued?

If you decide to stop giving your dog Galliprant, it’s recommended to do it under your vet’s supervision. Abruptly stopping certain medications could potentially cause adverse effects. Always consult with your vet for the best method to discontinue use.

16. Does Galliprant cure osteoarthritis?

Galliprant is used to manage the symptoms of osteoarthritis in dogs, including pain and inflammation, but it doesn’t cure the condition. Osteoarthritis is a progressive degenerative disease without a definitive cure. The goal of medication like Galliprant is to improve the quality of life for dogs suffering from this condition.

17. Can Galliprant be used in post-operative pain management?

The use of Galliprant for post-operative pain is at the discretion of the vet. Although the primary indication for Galliprant is osteoarthritis, it may be used in managing other types of pain, considering its safety profile and lower risk of kidney and liver damage.

18. Can my dog develop a resistance to Galliprant over time?

There is no reported evidence suggesting that dogs develop resistance to Galliprant over time. However, the disease progression of osteoarthritis might alter the perceived effectiveness of pain management over time.

19. How is Galliprant metabolized in my dog’s body?

Galliprant is primarily metabolized in the liver. However, due to its specific action on the EP4 receptor, it is considered less likely to cause liver toxicity compared to traditional NSAIDs. The metabolites are then eliminated through the feces.

20. Are there any natural alternatives to Galliprant?

While natural remedies such as glucosamine, chondroitin, omega-3 fatty acids, and others are often used to support joint health, they should not replace prescribed medication unless advised by your vet. If you are interested in incorporating natural supplements into your dog’s treatment plan, discuss this with your vet to ensure a balanced and effective approach.

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