Simparica Trio and Diarrhea in Dogs: How Long Will It Last?

Dog owners will do anything in their power to ensure their beloved pets are free from pests, and flea and tick preventatives like Simparica Trio are a common solution. However, these medications can sometimes come with side effects, one of which can be diarrhea. In this article, we will explore what Simparica Trio is, the link between Simparica Trio and diarrhea, and most importantly, how long this side effect may last.

What is Simparica Trio?

Simparica Trio is a chewable tablet used for the prevention and treatment of flea and tick infestations in dogs. This prescription medication also works to prevent heartworm disease and treat and control roundworms and hookworms. While this all-in-one preventative can be a game-changer for many pets, it’s not without potential side effects.

Simparica Trio and Diarrhea: What’s the Connection?

While adverse reactions to Simparica Trio are uncommon, the most frequent ones include vomiting and diarrhea. This may be due to the active ingredients used in the medication – sarolaner, moxidectin, and pyrantel. These substances work to eliminate parasites, but they can also irritate the digestive system, leading to loose stools or diarrhea in some dogs.

How Long Does the Diarrhea Last?

Generally, if the diarrhea is due to Simparica Trio, it would be expected to resolve within a day or two. This is because the medication’s active ingredients should pass through your dog’s system within this timeframe. However, each dog is different, and some may experience symptoms for a slightly longer period.

What to Do If Your Dog Has Diarrhea After Taking Simparica Trio?

If your dog experiences diarrhea after taking Simparica Trio, it’s essential to monitor their condition closely. Make sure they have access to plenty of clean, fresh water to avoid dehydration. If the diarrhea persists for more than two days or is accompanied by other symptoms such as lethargy, loss of appetite, or blood in the stool, it’s time to consult your veterinarian.

After your dog has gone 12-24 hours without eating, consider giving them a bland diet consisting of boiled chicken breast and rice for 2-3 days. This can help soothe their digestive system and firm up their stools. Gradually reintroduce their regular diet over a few days once their stools return to normal.


While diarrhea after taking Simparica Trio can be concerning, it’s usually short-lived and can be managed at home with a little care and attention. However, any prolonged or severe symptoms should always be evaluated by a veterinarian to ensure your dog’s health and well-being.

Frequently Asked Questions

Can Simparica Trio Cause Loose Stools in Dogs?

Yes, Simparica Trio can cause loose stools or diarrhea in dogs. These gastrointestinal issues are among the most common side effects of the medication. It’s important to note, however, that not all dogs will experience these side effects, and many tolerate the medication very well.

How Long Can Dog Diarrhea Last After Taking Simparica Trio?

The duration of diarrhea can vary from one dog to another. However, if the loose stools are a direct result of the Simparica Trio, it’s expected to clear up within one to two days. Should the diarrhea persist longer, it’s advised to consult a veterinarian as this might indicate another underlying issue.

How Can I Help My Dog Recover from Diarrhea After Taking Simparica Trio?

To help your dog recover, ensure they stay well-hydrated as diarrhea can quickly lead to dehydration. Temporarily replace their regular diet with a bland one, such as boiled chicken and rice, for a couple of days until the diarrhea subsides. Avoid giving them any treats or human food during this time. If the diarrhea doesn’t improve or worsens over a couple of days, contact your veterinarian.

Can Simparica Trio Cause Other Side Effects?

Aside from diarrhea and vomiting, other less common side effects of Simparica Trio may include decreased appetite, lethargy, and increased salivation. In rare cases, neurological symptoms like tremors, seizures, and ataxia may occur. It’s vital to monitor your dog after administering Simparica Trio and report any unusual behavior or symptoms to your vet.

What Should I Do if My Dog Took a Larger Dose of Simparica Trio?

If your dog ingests more than their prescribed dose of Simparica Trio, monitor them closely for signs of adverse reactions, which can include vomiting, diarrhea, tremors, and decreased appetite. If you notice any of these symptoms, or if your dog seems unwell, contact your veterinarian immediately. It’s crucial to keep all medications out of your dog’s reach to prevent accidental ingestion.

Are There Any Precautions to Take Before Giving My Dog Simparica Trio?

Before starting your dog on Simparica Trio, discuss your dog’s medical history with your vet, particularly if they have a history of seizures or neurological issues. Also, puppies less than eight weeks old and weighing less than 2.8 lbs should not be given Simparica Trio. Pregnant, breeding, or lactating dogs should only be given the medication under a veterinarian’s supervision.

Can Simparica Trio Interact with Other Medications?

Simparica Trio is generally safe to use with other medications. However, as with any treatment, it’s essential to inform your veterinarian about all medications, supplements, and over-the-counter products your dog is currently taking. Certain drug interactions could potentially increase the risk of side effects.

How Soon Can I Expect Simparica Trio to Start Working?

Simparica Trio begins to kill fleas within three hours and ticks within eight hours after administration. It continues to be effective for a full month. However, it’s vital to administer the medication as directed by your vet and maintain consistent monthly treatments to ensure continuous protection against fleas, ticks, and parasites.

What Should I Do If My Dog Vomits After Taking Simparica Trio?

If your dog vomits shortly after taking Simparica Trio, it might not have fully absorbed the medication. Consult your vet promptly. They might advise you to administer another full dose to ensure your dog is adequately protected from parasites. Remember not to re-dose without guidance from your vet.

Can Simparica Trio Cause Bloody Diarrhea in Dogs?

While diarrhea is a common side effect, bloody diarrhea is not typically associated with Simparica Trio. If your dog experiences bloody diarrhea, it’s crucial to contact your vet immediately. This could be a sign of a more serious health issue, such as gastrointestinal injury, infection, or a coagulation disorder.

Is Simparica Trio Safe for All Breeds of Dogs?

Simparica Trio has been tested and found to be safe for use in over 94 different breeds of dogs. However, each dog is unique, and breed alone does not determine how a dog will react to medication. Age, weight, overall health, and individual sensitivities must also be taken into consideration.

Can I Give Simparica Trio to My Cat?

No, Simparica Trio is specifically formulated for dogs. Using it on cats or other animals may lead to severe adverse reactions. Always use treatments that are specifically designed for each species, and never interchange without consulting a vet.

Can Simparica Trio Be Used In Pregnant or Lactating Dogs?

Simparica Trio has not been evaluated in pregnant, breeding, or lactating dogs. As such, it’s crucial to consult your vet before administering Simparica Trio to dogs in these categories. The veterinarian will be able to provide personalized advice based on the dog’s overall health and specific needs.

What Should I Do If I Miss a Dose of Simparica Trio?

If you forget to give your dog a monthly dose of Simparica Trio, administer it as soon as you remember. Then, continue with the regular monthly dosing schedule. It’s vital to give the medication every month, year-round, as recommended by your vet, to ensure your dog remains protected against fleas, ticks, and parasites.

Can I Give My Dog Simparica Trio If It Has Food Allergies?

Simparica Trio is administered orally, and no specific dietary restrictions are associated with its use. However, if your dog has known food allergies, it’s essential to discuss these with your vet. They can provide guidance on the best approach to administer the medication while avoiding potential allergic reactions.

How Should Simparica Trio Be Stored?

Simparica Trio should be stored at room temperature, between 68-77°F (20-25°C). It should be kept out of reach of children and pets. Avoid storing the product in excessively hot or cold environments and keep it in its original packaging until it’s time to administer it to your pet.

What Happens If My Dog Eats More Than One Simparica Trio Tablet?

In case your dog accidentally consumes more than the prescribed dose of Simparica Trio, contact your vet immediately. Overdosing can potentially increase the risk of adverse reactions. Symptoms might include vomiting, diarrhea, tremors, loss of appetite, and increased salivation. Immediate veterinary attention is vital in these cases.

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