6 Natural Alternative to Apoquel

If you’re looking for a natural alternative to Apoquel for your furry friend, these supplements are definitely worth considering. Just remember to always consult with your veterinarian before making any changes to your pet’s health regimen.

1. Zesty Paws Allergy Immune Supplement for Dogs


No harmful side effects – Unlike Apoquel which has potential side effects like vomiting, diarrhea and loss of appetite, Zesty Paws is a natural supplement made from ingredients like Omega-3 fatty acids, Vitamin E, and turmeric that are safe for your pup.

Promotes a healthy immune system – The ingredients in Zesty Paws work together to help boost your dog’s immune system, making it easier for them to fight off allergies and skin irritations.

Supports overall health – This supplement not only targets allergy symptoms, but also supports your dog’s overall health by providing essential vitamins and minerals that they need to live a healthy life.

Easy to administer – Zesty Paws comes in a convenient soft chew form that your dog will love. No more struggling to get them to take pills or liquids!

Affordable – Compared to prescription medications, Zesty Paws is a more affordable alternative for pet owners looking for a natural solution for their dog’s allergy symptoms.


Takes time to see results – Unlike prescription medications which work quickly, natural supplements like Zesty Paws may take several weeks to see results.

Not effective for all dogs – While Zesty Paws has been successful for many pet owners, it may not work for all dogs. Some dogs may need a different approach to manage their allergy symptoms.

Possible dietary restrictions – If your dog has specific dietary restrictions, it’s important to check the ingredients in Zesty Paws to make sure it’s safe for them to consume.

2. NaturVet Aller-911 Allergy Aid Plus Immune Support


All-natural ingredients: NaturVet Aller-911 is made with all-natural ingredients such as Quercetin, Vitamin C, and Omega-3 fatty acids, which are known to provide relief from allergy symptoms.

Immune support: This product not only helps with allergy symptoms but also provides immune support, which is beneficial in preventing future allergic reactions.

No side effects: Unlike Apoquel, which can cause side effects such as vomiting, diarrhea, and loss of appetite, NaturVet Aller-911 does not have any known side effects.

Easy to administer: This product comes in a soft chew form, which makes it easy for pet owners to administer to their furry friends.


Takes longer to work: Unlike Apoquel, which can provide relief from allergy symptoms within hours, NaturVet Aller-911 may take a few days to a week to see results.

Not effective for all dogs: Some dogs may not respond well to NaturVet Aller-911, and pet owners may need to try different natural alternatives until they find one that works for their furry friend.

May be more expensive: Natural alternatives to Apoquel may be more expensive than traditional medications, but they can provide peace of mind to pet owners who want to avoid exposing their dogs to harsh chemicals.

3. Nuleaf Naturals Full Spectrum CBD Oil for Dogs


First and foremost, it’s an all-natural solution, made with organic hemp extract, which means you’re not exposing your furry friend to any harsh chemicals.

CBD oil is a proven anti-inflammatory, so it’s great for treating skin conditions like allergies and dermatitis, as well as joint pain and arthritis.

Unlike Apoquel, CBD oil won’t suppress your dog’s immune system, making it a safer option for long-term use.

CBD oil is also known to improve anxiety and stress, so if your pup is prone to nervousness or nervous behavior, this could be a great alternative.

Nuleaf Naturals uses a full-spectrum extract, which means it contains all of the beneficial compounds found in the hemp plant, including terpenes, flavonoids, and essential oils.


While the all-natural aspect is great, it also means that the effectiveness can vary from dog to dog. Some dogs may not respond well to the oil, or it may take a longer time to work than Apoquel.

The price can also be a bit of a turn-off for some, as CBD oil can be more expensive than traditional medications.

It’s important to note that there is no standardization in the CBD industry, so finding a high-quality product can be a bit of a shot in the dark. Make sure you do your research and only purchase from reputable brands like Nuleaf Naturals.

Finally, CBD oil is not FDA approved, which means that the long-term safety and efficacy is not yet known. However, many veterinarians are starting to recommend it as a safe and effective alternative to traditional medications.

4. PetHonesty Allergy SkinHealth + 10 in 1 Multivitamin Soft Chew Supplement Bundle


Powerful ingredients like Flaxseed, Vitamin E, Probiotics, Small Fish Oil, Krill, Kelp and DHA Gold are filled with antioxidants, vitamins and healthy Omega-3’s and Omega-6’s that contribute to skin health.

The 10-in-1 Multivitamin Soft Chew Supplement Bundle is a great way to give your pet a comprehensive range of nutrients to support their overall health and wellness.

The bundle contains PetHonesty Allergy SkinHealth, which is specifically designed to address skin allergies and promote skin health.

The natural ingredients in PetHonesty Allergy SkinHealth are safe and gentle, making it a great alternative to prescription drugs like Apoquel.

The bundle is convenient and easy to use, as the soft chews are simply given to your pet like a treat.


PetHonesty Allergy SkinHealth and the 10-in-1 Multivitamin Soft Chew Supplement Bundle are not a cure for all skin allergies, so it’s important to consult with a veterinarian to determine the best course of action.

The natural ingredients in PetHonesty Allergy SkinHealth and the 10-in-1 Multivitamin Soft Chew Supplement Bundle may take longer to show results compared to prescription drugs like Apoquel.

The cost of the bundle may be higher compared to other natural alternatives to Apoquel.

5. Zesty Paws Aller-Immune Bites™ with EpiCor® for Dogs


The main active ingredient, Colostrum, is a naturally occurring substance that helps boost the immune system of dogs.

EpiCor® is a dried fermentate made using Saccharomyces cerevisiae, which is a yeast known to have a positive impact on the gut and overall health.

The 5-Strain Gut Health Blend, which includes Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus fermentum, and Lactococcus lactis, is designed to improve digestive health and overall wellness.

Apple Cider Vinegar and Salmon Oil are both well-known for their numerous health benefits, including improved digestion and skin health.

Astragalus Root is another natural ingredient that has been used for centuries to support immune function and overall health.


While the ingredients in Zesty Paws Aller-Immune Bites™ are all-natural, they may not be as effective as prescription drugs like Apoquel for some dogs.

Some dogs may not like the taste of the bites, which could make it difficult to get them to take the supplement regularly.

Natural remedies can take longer to work, as they support the body’s own systems and processes, rather than simply suppressing symptoms.

6. Pet Naturals Skin and Coat for Dogs with Dry, Itchy and Irritated Skin


Natural ingredients: Pet Naturals Skin and Coat for Dogs is made with natural ingredients like oat flour, flaxseed meal, salmon oil, and rosemary extract, which are gentle on your furry friend’s skin and provide nourishing benefits.

Helps with dry, itchy, and irritated skin: This product is specifically designed to help dogs with skin issues. The blend of ingredients helps to soothe and moisturize dry skin, reducing itching and discomfort.

Good source of vitamins and minerals: The product contains important vitamins and minerals like vitamin E, calcium, and omega-3 fatty acids, which support overall skin and coat health.

Easy to administer: Pet Naturals Skin and Coat for Dogs is available in chewable tablet form, making it easy for pet owners to give to their dogs.


Not suitable for all dogs: Some dogs may have allergies or sensitivities to the ingredients in the product. Before starting a new supplement, it’s important to consult with a veterinarian.

May take time to see results: As with any natural supplement, results may take time to show. Some dogs may see improvement in as little as a few days, while others may take a few weeks to notice a difference.

May be more expensive: Natural supplements can often be pricier than conventional medications, so this product may not be the most budget-friendly option for pet owners.

FAQs about natural Apoquel alternatives

Here are some frequently asked questions to help guide you in your search.

What is Apoquel?

Apoquel is a prescription medication used to treat skin allergies and itching in dogs. It works by blocking the itch sensation and reducing inflammation.

Why consider natural alternatives?

While Apoquel is effective, it can have side effects such as vomiting, diarrhea, and decreased appetite. Some pet owners prefer natural remedies that are less harsh on their pet’s system.

What are some natural alternatives to Apoquel?

There are several natural options to consider, including fish oil supplements, probiotics, herbal remedies like chamomile and aloe vera, and changes to your pet’s diet.

How do fish oil supplements help with allergies?

Fish oil supplements are high in omega-3 fatty acids, which have anti-inflammatory properties. These can help reduce itching and inflammation in pets with allergies.

What role do probiotics play in treating allergies?

Probiotics can help improve gut health, which is important for overall immune function. A healthy gut can help reduce inflammation and prevent allergic reactions.

What are some herbal remedies that can help with allergies?

Chamomile has anti-inflammatory and anti-itch properties, while aloe vera can soothe and heal irritated skin. These herbs can be used topically or in the form of a supplement.

How can diet changes help with allergies?

Some dogs may be sensitive to certain ingredients in their food, which can exacerbate allergies. Switching to a hypoallergenic or limited ingredient diet can help reduce symptoms.

Are natural alternatives as effective as Apoquel?

While natural alternatives may not work as quickly as Apoquel, they can be effective in reducing symptoms over time. It’s important to work with a veterinarian to find the best treatment plan for your pet.

How do I know if my dog has allergies?

Common signs of allergies in dogs include itching, scratching, licking, and biting at the skin. Some dogs may also have red, inflamed skin or develop hot spots. It’s important to have your pet evaluated by a veterinarian to rule out other potential causes of these symptoms.

Can natural remedies be used in combination with Apoquel?

While it’s important to work with a veterinarian to create a treatment plan, some natural remedies can be used in combination with Apoquel. For example, fish oil supplements may help reduce the dose of Apoquel needed to manage symptoms.

Are there any risks to using natural alternatives?

As with any treatment, there are potential risks to using natural alternatives. For example, some herbal remedies can be toxic to dogs in certain doses. It’s important to work with a veterinarian who is knowledgeable about natural remedies and can advise on safe dosages.

How long does it take for natural remedies to work?

The time it takes for natural remedies to work can vary depending on the individual dog and the severity of their symptoms. It’s important to be patient and consistent with treatment, and to work closely with a veterinarian to adjust the treatment plan as needed.

What should I look for in a natural supplement?

When selecting a natural supplement, look for products that are made from high-quality ingredients and have been tested for safety and effectiveness. It’s also important to choose a product that is appropriate for your dog’s age, weight, and health status.

Can diet changes help with allergies?

In some cases, allergies in dogs may be caused or exacerbated by certain ingredients in their diet. Switching to a high-quality, limited-ingredient diet can be helpful for some dogs with allergies. However, it’s important to work with a veterinarian to ensure that your dog is still getting all of the necessary nutrients.

Are there any natural alternatives to Apoquel that are backed by scientific research?

While there is limited scientific research on natural alternatives to Apoquel, some studies have suggested that omega-3 fatty acids and probiotics may be helpful in reducing allergy symptoms in dogs. However, more research is needed to confirm these findings.


Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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