Is NexGard Safe for Dogs? 🐕

NexGard is a widely used chewable flea and tick preventative for dogs that works by disrupting the nervous system of parasites. Despite its effectiveness, many dog owners have questions about its safety and potential side effects.


Key Takeaways 📝

  • Generally safe for most dogs when used as directed, but consult your vet.
  • Mild side effects, such as digestive upset, are most common.
  • Severe reactions are rare but can occur, particularly in sensitive dogs.
  • Not recommended for dogs with a history of seizures without vet advice.
  • Monitoring and dosage adherence are essential for safe usage.

What Makes NexGard Effective and Is It Safe for My Dog?

NexGard is an oral flea and tick treatment containing afoxolaner, an active ingredient that targets and disrupts the nervous system of parasites, killing them before they can transmit diseases. When used as directed, NexGard is considered safe for most dogs, including those over 8 weeks old and weighing more than 4 pounds. However, safety can vary based on individual health profiles, so a vet’s approval is always essential.

Important Note: Dogs with certain medical conditions, especially those with a history of neurological issues, should be evaluated carefully before using NexGard.

Safety FactorWhy It’s SafeVet’s Tip
🧪 Active IngredientTargets parasites specificallyEffective for monthly use
🐕 Age/Weight GuidelinesSafe for dogs >8 weeks, >4 lbsFollow manufacturer’s directions
⚠️ Pre-existing ConditionsMay increase risk in some dogsVet evaluation recommended

Takeaway: NexGard’s targeted action makes it effective and generally safe for most healthy dogs.


What Are the Common Side Effects of NexGard?

Most dogs tolerate NexGard well, but some may experience mild side effects, especially when taking it for the first time. The most common side effects include:

  • Digestive Upset: Vomiting or diarrhea shortly after administration.
  • Lethargy: Temporary decrease in energy or activity.
  • Appetite Changes: Increased or decreased interest in food.

Tip: Giving the chewable tablet with food can help reduce the likelihood of an upset stomach.

Side EffectDescriptionSeverity
🤮 VomitingMay occur after dosingMild, usually short-lived
💤 LethargyLess active for a dayMild to moderate
🍽️ Appetite ChangeIncreased or reduced interest in foodTemporary

Takeaway: Common side effects are typically mild and subside on their own.


Can NexGard Trigger Severe Reactions?

Severe reactions are rare but have been reported in some cases. These may include neurological symptoms such as tremors, seizures, or unusual behaviors. While these occurrences are infrequent, dogs with a known history of epilepsy or seizures may be at higher risk and require extra caution.

Pro Tip: If your dog shows signs like tremors or seizures after taking NexGard, discontinue use and consult your veterinarian immediately.

Severe ReactionIndicationImmediate Action
🌀 TremorsShaking or shiveringContact vet promptly
⚡ SeizuresConvulsions, loss of controlEmergency vet visit
😕 Behavioral ChangesAgitation, unusual conductMonitor and seek vet advice

Takeaway: Severe reactions are rare but should be addressed urgently if they occur.


Can Dogs with Pre-Existing Conditions Take NexGard?

Dogs with pre-existing conditions, such as epilepsy, liver disease, or immune system issues, may face increased risks when taking NexGard. The active ingredient, afoxolaner, can exacerbate neurological symptoms in dogs already predisposed to such issues. Before starting NexGard, discuss your dog’s full medical history with your vet to ensure it’s the safest choice.

Vet Insight: There may be alternative flea and tick preventatives that are more suitable for dogs with specific health challenges.

Pre-Existing ConditionRisk LevelVet’s Advice
🧠 EpilepsyHigher risk for seizuresVet monitoring required
🩺 Liver DiseasePotential impact on organ healthAlternative treatments
🦠 Immune IssuesMay weaken responseVet-consulted dosage

Takeaway: Disclose any health issues to your vet for tailored recommendations.


How Should I Administer NexGard Safely?

Proper administration is key to maximizing NexGard’s safety and effectiveness. Administer the chewable tablet once a month with or without food. If your dog tends to have a sensitive stomach, offering the dose alongside a meal can help. Monitor your dog for at least 24 hours after the first dose to spot any side effects.

Administration Tip: Use high-value treats or peanut butter to make taking the chewable more enjoyable if your dog is a picky eater.

Administration StepBenefitHow to Implement
🕓 Monthly DosingSustains protectionUse a reminder system
🍗 With FoodReduces upset stomachGive with or after meals
🎁 Treat WrappingMakes dosing easierWrap in a treat

Takeaway: Consistent, mindful administration promotes safe and effective use.


What Should I Do If I Miss a Dose?

If you miss a dose of NexGard, give it as soon as you remember, ensuring the timing aligns with the monthly schedule moving forward. If it’s close to the time for the next dose, just resume the regular schedule without doubling up. Missing a dose can reduce protection, so try to stay consistent.

Reminder Tip: Setting alarms or using pet care apps can help keep your dosing schedule on track.

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SituationActionOutcome
⏳ Missed by a Few DaysAdminister ASAPContinue regular schedule
📅 Close to Next DoseSkip and resumeAvoid double-dosing
🔔 Set RemindersConsistencyImproves protection

Takeaway: Prompt action helps maintain effective protection without risking overdose.


How Can I Monitor My Dog After Giving NexGard?

Observing your dog for 24-48 hours post-administration is crucial for spotting any immediate side effects. Keep an eye on energy levels, appetite, and bathroom habits. Subtle changes like a slight decrease in activity are common, but persistent symptoms or sudden changes should prompt a call to your vet.

Monitoring Tip: Document any side effects in a health log for future reference, especially if your dog is new to NexGard or has a complex health history.

Monitoring AspectWhat to Look ForResponse
💧 HydrationDrinking more or lessEnsure water access
🐾 Energy LevelsLethargy or restlessnessMild changes are typical
🤢 AppetiteSudden increase/decreaseWatch for persistent change

Takeaway: Careful observation ensures prompt action if side effects arise.


Can Puppies and Senior Dogs Safely Take NexGard?

NexGard is approved for puppies aged 8 weeks and older, weighing more than 4 pounds. However, young puppies may have a more sensitive system, so initial doses should be monitored closely. Senior dogs can also take NexGard, but they might experience side effects more intensely due to age-related health conditions. For older dogs, consult your vet for a personalized assessment, especially if they have other health issues.

Senior Care Insight: Combining NexGard with a joint supplement can support aging dogs that may be prone to stiffness or discomfort after administration.

Age GroupConsiderationsVet’s Note
🐶 PuppiesSensitive systemsMonitor closely
🐕‍🦳 SeniorsAge-related conditionsVet-tailored dosage
🩺 Routine Check-upsSupports safetyRecommended annually

Takeaway: Tailored vet guidance ensures safety for puppies and senior dogs alike.


Are There Natural Alternatives to NexGard?

For owners seeking natural alternatives to chemical preventatives, options include essential oil spraysherbal flea collars, and dietary supplements that support a flea-repellent coat. While these may provide some level of deterrence, they are not as reliable as prescription treatments like NexGard and may need to be used in combination for effectiveness.

Caution: Always research and choose pet-safe essential oils, as some can be toxic to dogs.

Natural AlternativeEffectivenessNotes
🌿 Essential Oil SprayModerateUse vet-approved oils
🪴 Herbal CollarsLow to moderateReplace regularly
🐟 Dietary SupplementsSupports coat healthCombine with other methods

Takeaway: Natural methods may help but don’t guarantee full protection like NexGard.


FAQs 💬


Comment 1: “Can NexGard affect my dog’s behavior or energy levels?”

Yes, some dogs may exhibit behavioral or energy changes after taking NexGard, although this is not typical. If it occurs, it may present as mild lethargy, reduced playfulness, or, conversely, restlessness. These changes are usually short-lived, lasting only 24-48 hours as the body adjusts to the medication. If you notice significant changes, such as pronounced anxiety or abnormal aggression, it’s crucial to contact your vet for advice, as these could signal an uncommon reaction.

Monitoring Insight: Keep a close watch on your dog’s energy and interactions in the first 24 hours post-administration to identify any unusual behavior.

Behavioral ChangePossible CauseRecommended Action
💤 LethargyNormal adjustmentMonitor for up to 48 hours
😕 RestlessnessMild discomfortProvide a calm space
😠 Aggression/AnxietyRare reactionContact your vet

Takeaway: Temporary behavior changes are typically harmless, but persistent or severe issues warrant vet consultation.


Comment 2: “Is NexGard safe for dogs with a history of allergies?”

NexGard is generally safe for most dogs, but those with a history of severe allergies should be carefully monitored after administration. Although it is rare, an allergic response to afoxolaner could include symptoms like itching, swelling, or hives. If your dog has food sensitivities or allergies to certain proteins, check with your vet to ensure NexGard’s formulation does not conflict with their dietary needs.

Allergy Management Tip: Administer NexGard in the morning so you can observe your dog throughout the day for any signs of an allergic reaction.

Allergy RiskSymptom to WatchImmediate Action
🤕 ItchingPersistent scratchingMonitor and contact vet if severe
🌡️ SwellingSwollen face or limbsEmergency vet visit
🤧 HivesSmall, raised bumpsAdminister antihistamines (vet-advised)

Takeaway: Dogs with known allergies should be monitored closely, and any signs of a reaction should prompt a call to your vet.


Comment 3: “What should I do if my dog vomits after taking NexGard?”

If your dog vomits within 2 hours of taking NexGard, it’s likely that the full dose wasn’t absorbed. In this case, consult with your vet to determine if another dose should be given. If vomiting occurs after 2 hours, sufficient absorption likely took place, so a replacement dose isn’t typically necessary. Watch for any other signs of gastrointestinal upset or changes in behavior following vomiting.

Practical Tip: Provide water to keep your dog hydrated if they experience vomiting and observe their energy levels.

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Timing of VomitingAbsorption LikelihoodAction to Take
⏳ Within 2 HoursMinimal absorptionContact vet for advice
⏱️ After 2 HoursLikely absorbedNo additional dose needed
💧 HydrationEssential after vomitingEnsure water availability

Takeaway: Timing is critical when assessing whether a repeat dose is needed. Always consult your vet for clarity.


Comment 4: “How long does it take for NexGard to start working?”

NexGard begins killing fleas and ticks within 4 hours of administration, with most parasites eliminated within 24 hours. This rapid action helps prevent the transmission of diseases carried by ticks and fleas. While the medication works fast, continuous monthly doses ensure that new infestations are controlled before they can establish.

Usage Tip: Administer NexGard on the same day each month to maintain uninterrupted protection against fleas and ticks.

Time FrameEffectivenessOwner’s Tip
⏳ 4 HoursInitial action startsMonitor for flea reduction
🕰️ 24 HoursFull effectivenessCheck for dead fleas/ticks
📅 Monthly UseMaintains controlSet reminders for dosing

Takeaway: Quick-acting and reliable, NexGard provides comprehensive protection when used consistently.


Comment 5: “What happens if my dog accidentally gets a double dose of NexGard?”

Accidentally giving your dog a double dose of NexGard can increase the risk of side effects such as vomiting, diarrhea, and lethargy. Although severe reactions from a single extra dose are uncommon, it’s important to monitor your dog for any signs of distress. If any severe symptoms appear, such as tremors or seizures, seek immediate veterinary attention.

Safety Tip: Store NexGard in a secure place and mark dosing schedules on a calendar to prevent accidental double dosing.

Double Dose EffectPossible OutcomeOwner’s Response
🤢 Vomiting/DiarrheaLikely side effectMonitor and provide water
💤 LethargyTemporary fatigueRest and observation
⚠️ Severe SymptomsRare but seriousEmergency vet visit

Takeaway: Stay vigilant and consult your vet for guidance if an accidental double dose occurs.


Comment 6: “Can I give NexGard to my pregnant or nursing dog?”

The safety of NexGard for pregnant or lactating dogs has not been fully established through clinical trials. For dogs that are pregnant or nursing, consult your veterinarian to weigh the benefits and risks of using NexGard versus alternative options. Some vets may advise against using NexGard in these cases, opting for treatments that have been more thoroughly tested for reproductive safety.

Vet Consultation Tip: Always disclose pregnancy or nursing status before starting any new medication.

ConditionSafety StatusVet’s Advice
🤰 Pregnant DogsUncertainConsult vet for safer alternatives
🍼 Nursing DogsNot fully testedVet evaluation needed
🐾 Alternative TreatmentsConsidered saferBased on vet recommendation

Takeaway: Prioritize a vet’s guidance for pregnant or nursing dogs to ensure safety.


Comment 7: “Can NexGard be given alongside heartworm prevention medication?”

Yes, NexGard can be safely administered with most heartworm prevention medications like Heartgard or Interceptor Plus. These products target different parasites, making them complementary in maintaining your dog’s overall parasite protection. However, always consult your vet before combining medications to ensure your dog’s specific health profile is taken into account.

Combination Tip: If administering multiple medications on the same day, keep an eye on your dog for any unexpected reactions and report them to your vet.

Medication PairingCompatibilityOwner’s Note
💊 Heartworm MedsSafe with NexGardVet-checked combo
🐛 Flea/Tick + HeartwormComprehensive protectionMonitor after dosing
📝 Vet ConsultationEnsures safetyRegular check-ups

Takeaway: NexGard can be used with heartworm preventatives for full-spectrum parasite control under vet supervision.


Comment 8: “Are there any known drug interactions with NexGard?”

NexGard is generally safe and doesn’t have many known drug interactions. However, combining it with other medications that affect the nervous system should be done with caution. If your dog is on medications like anticonvulsants or sedatives, discuss this with your vet before starting NexGard. This will help avoid any unintended interactions or compounding side effects.

Drug Safety Tip: Keep a complete list of your dog’s current medications and supplements to share with your vet.

Potential InteractionMedication TypeVet’s Precaution
⚡ AnticonvulsantsNeurological impactsVet-guided usage
😴 SedativesMay amplify lethargyCareful monitoring
💊 Other PreventativesLow riskVet input recommended

Takeaway: Be transparent with your vet about all medications to ensure safe NexGard administration.


Comment 9: “Can NexGard be given year-round, or is it seasonal?”

NexGard can and should be given year-round in most climates, especially in regions where fleas and ticks are prevalent year-round. Consistent monthly dosing prevents gaps in protection, reducing the risk of infestations and tick-borne diseases. Even in colder climates, certain ticks and fleas can survive and pose a threat during warmer spells.

Seasonal Tip: Use a monthly calendar or app reminder to maintain year-round dosing without interruption.

Dosing PeriodReasonOwner’s Action
🌍 Year-RoundEnsures consistent protectionMonthly reminders
❄️ Cold ClimatesFleas/ticks may surviveMaintain coverage
📅 Regular SchedulePrevents lapse in efficacySet alerts

Takeaway: Year-round dosing is the best practice for reliable flea and tick prevention.

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Comment 10: “How do I know if NexGard is working effectively?”

You’ll know NexGard is working effectively if your dog remains free of flea bites and tick attachments after consistent monthly dosing. While the medication starts acting within 4 hours, checking your dog’s coat and skin regularly for live fleas or ticks is beneficial, especially after walks in wooded areas. A significant reduction or absence of parasites on your dog indicates that NexGard is performing as intended.

Evaluation Tip: If you see dead fleas or ticks on your dog’s coat, it’s a sign that the medication has killed them before they could cause harm.

Effectiveness CheckObservationOutcome
🐾 No Flea BitesSmooth, bite-free skinMedication is working
✅ Dead TicksTicks found but deadNexGard is effective
🔎 Regular ChecksCoat inspectionEnsures continuous protection

Takeaway: Regular checks reinforce confidence that NexGard is protecting your dog effectively.


Comment 11: “What should I do if my dog experiences a reaction to NexGard?”

If your dog experiences a reaction to NexGard, whether mild or severe, immediate action is crucial. For minor side effects such as vomiting, diarrhea, or lethargy, observe your dog closely and ensure they have access to fresh water and a comfortable place to rest. If these symptoms persist beyond 24-48 hours, consult your vet to discuss potential adjustments to their treatment plan or switching to an alternative preventative.

For serious reactions like seizures, tremors, or signs of an allergic response (e.g., swelling, difficulty breathing), discontinue use and seek veterinary attention immediately. These signs could indicate a more profound sensitivity to the medication that may require emergency intervention.

Quick Action Tip: Keep a record of when symptoms began, their severity, and any additional details to help your vet diagnose and respond effectively.

Reaction SeveritySymptomsRecommended Response
🤢 MildVomiting, mild lethargyMonitor, vet visit if prolonged
⚠️ ModeratePersistent diarrhea, repeated vomitingCall vet promptly
🚨 SevereSeizures, severe swellingEmergency vet visit

Takeaway: Early response and detailed monitoring help ensure your dog’s safety and well-being.


Comment 12: “Can NexGard cause long-term health effects in dogs?”

Long-term use of NexGard has been deemed safe for most dogs, but concerns remain about potential cumulative effects, especially in dogs with pre-existing health conditions or sensitivities. While it is rare, prolonged use could theoretically contribute to neurological symptoms in dogs predisposed to such issues. Routine vet visits, which include neurological and physical health assessments, are vital to ensure ongoing safety.

Regular monitoring allows for the identification of any subtle changes in behavior, energy levels, or physical health that may need attention. This is particularly important for breeds known to have higher neurological sensitivities.

Health Maintenance Tip: Incorporate regular blood work and health checks into your dog’s wellness routine to catch any emerging issues early.

Potential Long-Term ConcernWhat to Watch ForPrevention Strategy
🧠 Neurological ImpactTremors, head tiltingAnnual vet evaluations
🩺 Cumulative SensitivityBehavior changesRoutine blood work
🐾 Overall HealthGradual changesConsistent monitoring

Takeaway: Long-term safety relies on consistent vet oversight and awareness of your dog’s health.


Comment 13: “Is NexGard safe for multi-pet households?”

NexGard is considered safe for use in multi-pet households, as long as each pet receives the correct dosage for their size and weight. Ensure that the prescribed doses are administered separately to avoid accidental ingestion by other pets, especially smaller ones that could be more sensitive to the active ingredient, afoxolaner.

If multiple pets share living spaces, it’s essential to keep an eye out for any allergic reactions, as some pets might have sensitivities that others do not. Additionally, if your pets groom each other frequently, allow time for the medication to be absorbed before letting them interact closely.

Multi-Pet Tip: Administer NexGard at a time when you can monitor interactions to prevent accidental licking or sharing of medication.

Household ConsiderationSafety PracticeReason
🐕‍🦺 Correct DosingMatch dose to each petPrevents overdosing
⏳ Separation TimeWait before interactionEnsures absorption
👀 ObservationWatch for reactionsEarly intervention

Takeaway: Individualized dosing and observation ensure safety in multi-pet households.


Comment 14: “Can NexGard be used alongside natural flea repellents?”

Yes, natural flea repellents like essential oil sprays, herbal powders, or dietary supplements can be used alongside NexGard to create a multi-layered approach to parasite prevention. Natural methods can help repel fleas and ticks between monthly NexGard doses, providing added peace of mind, particularly during peak flea and tick seasons.

However, it is important to choose pet-safe natural products and ensure that essential oils such as tea tree or eucalyptus are properly diluted, as these can be toxic to pets in concentrated forms. Always consult your vet before adding new products to your pet’s care routine to avoid potential interactions or adverse effects.

Combination Tip: Use natural products as complementary, not primary, defenses to enhance overall protection.

Natural OptionEffectiveness LevelVet Safety Check
🌿 Herbal SpraysModerateVet-reviewed formulas
🪴 Dietary AdditionsMildVet advice required
🌱 Essential OilsVariesMust be pet-safe

Takeaway: Natural repellents can support, but should not replace, the protection provided by NexGard.


Comment 15: “What signs indicate that NexGard isn’t working as effectively?”

Signs that NexGard may not be working effectively include persistent flea infestationstick attachments, or an increase in itching and scratching despite monthly dosing. While it typically works well within 4-24 hours to eliminate fleas, some environmental factors, such as heavy infestations, can challenge its efficacy. Ensuring that your home and yard are treated for fleas and ticks helps maintain optimal control.

Owner Insight: If you consistently notice live fleas or attached ticks despite using NexGard, consult your vet. A change in treatment strategy or additional measures may be necessary.

Ineffectiveness SignPossible ReasonAction
🐜 Live Fleas PersistEnvironmental reinfestationTreat home/yard
🐛 Tick PresenceHigh exposure areaReview prevention plan
🤔 Increased ScratchingPotential resistanceVet consultation

Takeaway: Ongoing infestations may require combined treatment strategies for full control.


Comment 16: “Can I bathe my dog after giving NexGard?”

Yes, you can bathe your dog without affecting the efficacy of NexGard. Unlike topical treatments that may wash off, NexGard is an oral medication that works systemically, meaning it is absorbed into your dog’s bloodstream and remains active regardless of bathing or swimming. This makes NexGard particularly convenient for dogs that love water activities or require frequent baths.

Grooming Tip: Wait at least 24-48 hours post-administration for best practice, but bathing immediately does not impact the efficacy of the chew.

Bathing TimingImpact on EfficacyOwner’s Practice
🕒 Before DosingNo impactNormal routine
🐾 After DosingSafe to bathe24-48 hour buffer preferred
🌊 Frequent SwimmingSafe with NexGardNo re-dosing needed

Takeaway: NexGard remains effective regardless of bathing or swimming, making it ideal for active dogs.


Comment 17: “What should I do if my dog shows resistance or dislike towards the chewable tablet?”

If your dog is reluctant to take the NexGard chewable, there are a few strategies you can try to make administration easier:

  1. Disguise It: Hide the chewable in a small amount of peanut butter, cheese, or another favorite treat.
  2. Mix It: Crumble the chewable into wet food or mix with a small portion of broth.
  3. Hand-Feed: Make the chew seem like a treat by offering it directly and following up with praise or a high-value reward.

Trick Tip: Administer the chew during a relaxed time when your dog is less guarded, like after a walk or play session.

MethodWhy It HelpsApplication
🍗 Treat DisguiseMasks flavorPeanut butter or cheese
🍲 Wet Food MixEasier consumptionCrumble and mix
👏 Positive ReinforcementEncourages acceptanceFollow with praise

Takeaway: Creative approaches ensure successful administration without stress.


Comment 18: “What are the advantages of NexGard over topical flea and tick treatments?”

NexGard offers several advantages over topical treatments, particularly in convenience and reliability. As an oral medication, NexGard cannot be washed off or diminished by bathing or swimming, making it ideal for dogs that enjoy water or have frequent grooming needs. It also eliminates the potential for contact transfer, where topicals may inadvertently be spread to other pets or humans.

Convenience Insight: Dogs that have sensitive skin or experience irritation from topical treatments may benefit from NexGard’s oral formulation.

AdvantageBenefitIdeal For
🐕 WaterproofWorks regardless of bathingActive, outdoor dogs
✋ No Contact RiskSafe for multi-pet homesHouseholds with children/pets
🚫 Skin-FriendlyNo topical residueDogs with sensitive skin

Takeaway: NexGard’s oral format offers reliable, easy protection without the downsides of topical treatments.


Comment 19: “Does NexGard have any impact on my dog’s heartworm prevention plan?”

NexGard specifically targets fleas and ticks and does not prevent heartworms. However, it can be safely paired with heartworm prevention medications for a comprehensive parasite control plan. Using products like Heartgard or Sentinel alongside NexGard ensures full protection from both external and internal parasites.

Comprehensive Care Tip: Discuss your pet’s full parasite prevention plan with your vet to ensure each product complements the other without interactions.

Parasite ControlCoverageCombination
🐛 NexGardFleas and ticksSafe with heartworm meds
🪱 Heartgard/SentinelHeartworms, internal wormsCombines for full coverage
🩺 Vet ReviewConfirms safetyRoutine check-ins

Takeaway: Pairing NexGard with a heartworm preventative completes your dog’s protection plan.


Comment 20: “What if my dog eats more than one NexGard chew accidentally?”

If your dog accidentally consumes more than one NexGard chew, monitor them closely for signs of an overdose, such as vomiting, diarrhea, or lethargy. While NexGard has a wide margin of safety, excessive intake could lead to increased risk of more serious side effects, including tremors or seizures in sensitive dogs. If you notice any concerning symptoms, contact your veterinarian immediately for guidance.

Safety Tip: Keep medications stored out of reach to prevent accidental ingestion.

Accidental IntakePotential SymptomImmediate Response
🍽️ Single Extra DoseMild stomach upsetMonitor, contact vet if needed
💊 Multiple DosesLethargy, tremorsEmergency vet contact
🔒 Secure StoragePrevents future incidentsStore high or locked away

Takeaway: Quick action and secure storage can prevent and address accidental overconsumption effectively.

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