K9 Advantix II Large Dog Reviews

Many pet owners are familiar with Frontline Plus and Advantage, two popular flea and tick preventative products that are available in both a large dog size (for dogs over 25 pounds) and a small dog size (for dogs under 25 pounds). These products work very well, but they can also be quite expensive. If you have a large dog and are looking for an economic alternative to Frontline Plus, consider K9 Advantix II.

Is K9 Advantix II good for dogs?

K9 Advantix II is manufactured by the Bayer Corporation. The active ingredient in K9 Advantix II is imidacloprid, which is a neurotoxin that affects the central nervous system of insects. It works so quickly that it kills fleas before they can lay their eggs. It also contains permethrin, which is an insect growth regulator that prevents ticks from reaching sexual maturity. Both ingredients are extremely effective at killing adult fleas and ticks. This product also repels mosquitoes and flies.

Ticks can transmit Lyme disease and Rocky Mountain spotted fever, which can cause serious illness or death in animals. K9 Advantix II kills ticks for at least one month and keeps them off your pet for at least that long. Your vet can recommend a tick-control strategy for your area, but protecting your dog from ticks is important if you live in or visit states where these bugs are prevalent.

K9 Advantix II comes with a convenient applicator that makes it simple to apply the product to your dog’s skin, making it easy to give him his monthly flea and tick treatment. It doesn’t take long before this product begins working to kill insects that bite your dog.


“I bought this for my German Shepard, he weighs about 100 lbs, I was using Frontline prior to this and it doesn’t work as well. It’s been about 2 weeks since I applied this product and he hasn’t had any fleas or ticks so far. I also have a border Collie that is about 80 lbs, she isn’t as hyperactive as my German Shepard and this works great. She isn’t scratching or anything like that and she doesn’t mind me applying it! So overall, I recommend this product over Frontline.”

“I’ve heard great things about K9 Advantix II through many of my friends who have used it on their pets. I decided to give it a try on my dog, as he has been scratching his rear end raw and I was concerned that it might be an insect bite (he’s an outside dog). He had been limping a little bit and I was worried that he might have injured his leg somehow. After applying K9 Advantix II to his back and belly, he stopped scratching and the limp went away! The only negative thing I can say is that the product can be a little messy to apply, but you will have absolutely no regrets if you use this product.”

“I found this website when searching online for K9 Advantix II Large Dog Reviews. I had two dogs that were having trouble with fleas. One of my dogs is a lab mix, and one is a German Shepherd mix. The K9 Advantix II Large Dog Flea Control was perfect for both of them because it protects them against fleas, ticks, and mosquitoes. My lab mix is 7 years old and has never had any problems with allergies or skin irritation from the products I have used on him. He is very playful and happy all the time, which might be due to K9 Advantix II Large Dog Flea Control. The K9 Advantix II Large Dog Flea Control worked great on my German Shepherd too. She is very playful as well and has lots of energy. She also has a ton of hair which I usually groom with regular brushing and trimming. Since using the K9 Advantix II Large Dog Flea Control with her she has been less irritated than normal by these grooming activities. I love how after just one application of the K9 Advantix II Large Dog Flea Control you can see immediate results in flea control! The price isn’t too bad either.”

“I got this for my lab mix and we had to use it in the middle of winter and I found that her coat was really greasy and shiny. I spoke with a vet, a friend of mine, and she said this is a common side effect when dogs get this product because it is overstimulating their oil glands. She said the only way to fix it is to wash their hair with baby shampoo or olive oil.”

“I have no complaints about this product. I have a lab and he weighs about 110 pounds. He gets his first tick check every month and so far we haven’t found any ticks on him. I think it’s great. Enough said!”

How to Use K9 Advantix II

When applying this product, make sure to follow all directions exactly as they are printed on the packaging.

This medication should be applied to a clean dog that has no other topical medications applied within 24 hours before or after applying K9 Advantix II. After applying the medication you should wait until it has dried.

Do not bathe your dog within 24 hours of applying this medication because it will not have time to dry and absorb before the bath washes it off.


K9 Advantix II is a flea and tick control product for dogs. At the time of writing, the product had 4.4 out of five stars on Amazon with over 2,000 reviews. Many reviewers noted that it was a safe and effective product to use on both small breed dogs and larger breeds as well as on cats.

However, some buyers have found that this product causes problems for their dogs. The most common complaint is that the medication causes itching and scratching. Other customers have reported that their dogs experienced allergic reactions after using this product. If your dog has sensitive skin, this may not be the best product for him or her.

“This is my review of K9 Advantix II Large Dog. I live in Florida, USA and we have a lot of fleas here. This year has been particularly bad, so I decided to try some new products. The first one that I used was Frontline Plus for Dogs. My dog had a reaction to it, so then I thought maybe the problem was that it hadn’t been applied well enough or often enough. So, I tried K9 Advantix II Large Dog next. It lasted about 3 weeks before the fleas were back and biting my dog again. I even tried Advantix for Cats today since the dogs and cats share the same yard and both get infested with fleas at the same time. There seems to be no product on the market that works well in Florida. The cats don’t mind the flea bites much but my dog scratches himself raw sometimes trying to get them off.”

Side effects

It is important to remember that some dogs are allergic or sensitive to Advantix II. Some signs of sensitivity may include redness, itching or other skin irritation; increased thirst and urination; vomiting; diarrhea; lethargy; drooling or panting; facial swelling; seizures. If you suspect that your dog has had an adverse reaction to any medication you should discontinue use immediately and contact your veterinarian.


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Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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