Can I Give My Dog Benadryl and Melatonin?

When it comes to our dogs, we want to be sure that anything we give them is safe. Lots of dog owners give human medications to their dogs. While some are safe in small doses, others can be highly toxic.

  • Benadryl can be used in small doses to treat mild health conditions but there are side effects to consider.
  • Melatonin is secreted naturally by the body and regulates the sleep cycle. In the evenings, melatonin levels rise to prepare the body for sleep. In the hours before sunrise, the body stops secreting melatonin to trigger wakefulness.

Can I give my dog Benadryl and Melatonin together?

You can give either Melatonin or Benadryl in small doses but never both together. While melatonin is a natural substance, both treatments cause drowsiness, giving both medications together can cause an overdose, which can quickly be fatal.

Always consult with your veterinarian before giving your dog over-the-counter medications or natural remedies.

Can Benadryl help dogs sleep?

Many dog owners wonder if they can give their dog Benadryl to help with sleep as the medication is known to cause drowsiness. This is not a good idea as giving Benadryl on a regular basis can lead to long-term health problems for your dog. It also does not treat the cause of your dog’s insomnia.

You can give your dog Benadryl temporarily, but never on a regular basis. A safe dosage as a one-off or for a couple of days is 2mg per kilo of body weight or 1mg per pound. Doses should be given at least 8 hours apart. Benadryl should never be given to pregnant dogs or those suffering from heart failure, seizures, lung disease or high blood pressure.

A better solution for your dog’s insomnia is to find the cause of his restless sleep and fix that. It could be due to an illness or injury, allergies, lack of exercise or separation anxiety. Treating the cause will stop the restless sleep and you will not need to give your dog any kind of sedative.

How much Melatonin can you give a dog?

Melatonin tablets are designed to dissolve quickly in the dog’s mouth. They come in small (1 mg), medium (2 mg), and large (4 mg) doses.

Most veterinarians recommend giving dogs melatonin no more than 3 to 5 times a week, depending on the severity of the sleep disorder. The dosage should be based on the size of your dog, as some dogs have more sensitive systems than others.

What are the side effects of Melatonin in dogs?

The following side effects have been reported in dogs taking the drug melatonin: changes in fertility, gastric upset and stomach cramps, increased heart rate, itching, confusion.

What is a natural sedative for a dog?

There are all kinds of products on the market that are designed to help calm dogs. These are called calming aids. Natural sedatives for dogs usually combine calming herbs, flower extracts, pheromones, and essential oils to help calm your dog.

Does Benadryl help dogs with mast cell tumors?

When a substance enters the dog’s body that they are allergic to, the body secretes histamines. This causes the typical symptoms of an allergic reaction such as hives and a runny nose. Benadryl contains diphenhydramine which is an antihistamine used to treat mild allergic reactions.

Mast cell tumors are a mass of white blood cells which also secrete histamine and can cause the symptoms of an allergic reaction. Benadryl can be used in low doses over a short period to treat skin irritation and sore eyes.

There are specific treatments for mast cell tumors that are far more effective and will treat the tumors themselves, not just the symptoms they cause.

Will Melatonin kill a dog?

The combination of Melatonin and Benadryl, a popular over-the-counter allergy medication, is potentially deadly to dogs. Melatonin is a hormone that tells your body when it’s time to sleep. Benadryl is an allergy medication that can cause drowsiness in some dogs. This mixture can lead to serious side effects like irregular heartbeat or even death.

Will Benadryl kill my dog?

Yes, it is possible for a dog to ingest or be given a lethal dose of Benadryl. This can happen if a pet owner or caregiver is careless with their pet medication.


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Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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