šŸ¾ Pregabalin vs Gabapentin vs Other Products: Which is Best for Your Dogā€™s Pain or Seizures?

When it comes to managing nerve pain, seizures, or even anxiety in dogs, medications like Pregabalin and Gabapentin are often prescribed by veterinarians. But which one is better suited for your petā€™s needs? How do they compare with other alternatives?


Key Takeaways: Quick Answers on Pregabalin, Gabapentin, and Alternatives šŸ¶

  • Whatā€™s the difference between Pregabalin and Gabapentin?Ā Both are anticonvulsants, butĀ PregabalinĀ is newer, more potent, and has a faster onset, whileĀ GabapentinĀ is more widely used and affordable.
  • Which one is better for pain?Ā PregabalinĀ may be more effective for nerve pain, butĀ GabapentinĀ is still a reliable and commonly used option.
  • Are there side effects?Ā Yes, both can causeĀ drowsiness,Ā wobbliness, andĀ weight gain, though Pregabalin might cause these to a greater degree.
  • What about alternatives?Ā Options likeĀ AmantadineĀ andĀ TramadolĀ are used for pain, whileĀ PhenobarbitalĀ orĀ KeppraĀ can be considered for seizure control.
  • How long does it take to work?Ā PregabalinĀ tends to act faster, but both medications requireĀ regular useĀ to maintain effectiveness over time.

Whatā€™s the Main Difference Between Pregabalin and Gabapentin?

Although both Pregabalin and Gabapentin belong to the same class of medications (anticonvulsants), they have key differences in potency, absorption, and duration of action. Hereā€™s how they compare:

AspectPregabalinGabapentinšŸ’” Tip
PotencyMore potent, often effective at lower dosesLess potent, requires higher doses for similar effectsPregabalin may be a better choice for severe cases.
Onset of ActionFaster onset (1 hour)Slower onset (up to 2 hours)For immediate relief, Pregabalin might be preferable.
Duration of EffectLasts longer with more stable blood levelsShorter duration, may require more frequent dosingPregabalin is more convenient with fewer doses.
CostMore expensiveMore affordableGabapentin is easier on the wallet, especially for long-term use.

šŸ’” Pro Tip: If your dog has been on Gabapentin but isnā€™t responding as well as expected, ask your vet if switching to Pregabalin could offer better control, especially for chronic nerve pain or refractory seizures.


Which Medication is Better for Managing Nerve Pain in Dogs?

Both Pregabalin and Gabapentin are commonly used to treat neuropathic pain, especially in conditions like arthritis, spinal injuries, or chronic pain syndromes. However, Pregabalinā€™s higher potency may give it an edge in more severe cases.

MedicationEffectiveness for Nerve PainšŸ’” Tip
PregabalinMore potent for neuropathic pain, offering quicker reliefGood option for dogs with severe or long-term nerve pain that isnā€™t controlled with Gabapentin.
GabapentinEffective but may require higher doses for severe painStill a reliable first-line treatment for most dogs, especially for mild to moderate pain.

šŸ’” Pro Tip: Combination therapy is often recommended for complex pain management. If nerve pain persists, adding anti-inflammatory drugs or pain relievers like Amantadine can enhance the effect of these medications.


Are There Side Effects with Pregabalin or Gabapentin?

Like any medication, Pregabalin and Gabapentin come with potential side effects. In most cases, these drugs are well tolerated, but itā€™s important to monitor your dog for any changes, especially during the first few weeks of treatment.

Side EffectPregabalinGabapentinšŸ’” Tip
DrowsinessCommon, often more pronouncedCommon but less severeStart with a lower dose and gradually increase as needed.
Ataxia (Wobbliness)Can be more noticeable due to potencyCommon but less intenseWatch for unsteady walking or coordination issues.
Weight GainModerate risk with long-term useCan also cause mild weight gainAdjust diet and activity to manage weight.
Diarrhea or GI UpsetRare but possibleRare but possibleAdminister with food to minimize stomach issues.

šŸ’” Pro Tip: If side effects become problematic, talk to your vet about adjusting the dose or spacing out the medication to minimize discomfort. Sometimes, even slight changes in timing can reduce the intensity of side effects.


What Are Some Alternatives to Pregabalin and Gabapentin?

If your dog doesnā€™t respond well to Pregabalin or Gabapentin, or if they experience side effects, there are alternative medications available. These alternatives target either pain or seizures, depending on your dogā€™s specific needs:

MedicationUsed ForEffectivenessšŸ’” Tip
AmantadinePain relief (especially for arthritis)Potent pain modulator; often used alongside other medsWorks well in combination with Gabapentin for complex pain cases.
TramadolPain relief (opioid)Short-term pain control, especially after surgery or injuryBetter for acute, short-term pain management.
Keppra (Levetiracetam)Seizure controlEffective for idiopathic epilepsy, fewer side effects than traditional anticonvulsantsWorks well when combined with other seizure medications like Phenobarbital.
PhenobarbitalSeizure controlOne of the most effective anticonvulsants, but comes with sedation and liver risksOften used when seizures are frequent or severe.

šŸ’” Pro Tip: Multi-modal pain management is often the best approach. For instance, if nerve pain isnā€™t fully controlled, combining Gabapentin with NSAIDs or Amantadine can create a more comprehensive pain relief strategy.


How Quickly Do Pregabalin and Gabapentin Work?

When managing pain or seizures, timing is everything. Pregabalin tends to act faster and stay effective for longer compared to Gabapentin, but both require regular use for optimal results:

MedicationOnset of ActionHow Long It LastsšŸ’” Tip
Pregabalin30 minutes to 1 hourLasts about 8-12 hoursIdeal for dogs that need quicker relief from pain or seizures.
Gabapentin1 to 2 hoursLasts about 4-6 hoursMay require more frequent dosing, but works well for long-term use.

šŸ’” Pro Tip: Be consistent with dosing! Skipping doses can lead to fluctuations in pain control or seizure prevention, so itā€™s important to follow your vetā€™s instructions closely.

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Are Pregabalin and Gabapentin Safe for Long-Term Use?

Both medications are generally considered safe for long-term use, especially when prescribed at appropriate doses and monitored closely by a vet. However, because Pregabalin is newer and more potent, its long-term effects are still being studied.

  • GabapentinĀ has been used extensively in veterinary medicine, and most dogs tolerate it well even over several months or years.Ā Routine bloodworkĀ may be recommended to monitor kidney or liver function in older dogs or those with pre-existing health conditions.
  • PregabalinĀ may require more careful monitoring, especially due to its higher potency and the potential for more pronounced side effects.Ā Regular vet check-upsĀ are essential to ensure that your dog continues to tolerate the medication well.

šŸ’” Pro Tip: Gradual tapering is necessary if you plan to stop either medication. Abruptly discontinuing Pregabalin or Gabapentin can lead to withdrawal symptoms, especially in dogs that have been on the medication long-term.


šŸ“Š Comparison of Pregabalin, Gabapentin, and Alternatives at a Glance

MedicationBest ForProsConsšŸ’” Tip
PregabalinSevere nerve pain, seizuresMore potent, fewer doses neededMore expensive, more pronounced side effectsGreat for cases where Gabapentin isnā€™t effective.
GabapentinModerate pain, seizuresAffordable, widely used, well-toleratedRequires more frequent dosingA good first choice for long-term management.
AmantadineChronic pain (arthritis)Effective pain modulationCan cause GI upset in some dogsUse in combination with other pain medications.
KeppraSeizure controlFewer side effects, non-sedativeRequires multiple doses dailyA solid option for dogs that donā€™t tolerate Phenobarbital.

šŸ—ļø Key Takeaways for Choosing Between Pregabalin, Gabapentin, and Alternatives

  • PregabalinĀ offers faster and more potent relief but comes with a higher price tag and more noticeable side effects.
  • GabapentinĀ is widely used for both pain and seizures, is affordable, and generally well-tolerated.
  • AlternativesĀ likeĀ Amantadine,Ā Tramadol, andĀ KeppraĀ can be used in combination for pain and seizure control, especially when one medication isnā€™t enough.
  • Long-term useĀ is safe with proper monitoring, but always follow your vetā€™s guidance to adjust doses or manage side effects.

By understanding the differences between Pregabalin, Gabapentin, and other options, you can make an informed choice to help your dog live a happier, more comfortable life. šŸ¾šŸ’–


Comment 1: ā€œHow do I know if Gabapentin or Pregabalin is working for my dogā€™s pain?ā€

To determine if Gabapentin or Pregabalin is effectively managing your dogā€™s pain, youā€™ll need to closely observe behavioral and physical changes. Since dogs canā€™t verbalize their pain, paying attention to their overall comfort and mobility is key. Here are some telltale signs that the medication is doing its job:

  • Increased Activity Levels:Ā One of the clearest indicators of pain relief is your dog becoming more active. If theyā€™re more willing to move, jump, or climb stairsā€”activities that were previously avoided due to painā€”this is a good sign the medication is working.
  • Improved Mood:Ā Dogs in pain may become withdrawn or irritable. When medication is effective, youā€™ll likely notice your dogā€™s personality return to normalā€”more playful, interactive, and willing to engage with family members.
  • Reduction in Limping or Stiffness:Ā If the medication is managing nerve pain effectively, your dog should show less limping, especially after long periods of rest.Ā Stiffness in the joints or musclesĀ should also diminish over time.
  • Restful Sleep:Ā Dogs in pain may have trouble settling down or sleeping through the night. If your dog starts to sleep more soundly and without constant repositioning, itā€™s another sign that the medication is working.
  • Less Sensitivity:Ā For dogs withĀ nerve pain, particularly those suffering from conditions like intervertebral disc disease (IVDD), sensitivity to touch may decrease. If you notice that your dog is no longer flinching or avoiding touch in painful areas, this is a clear indicator of pain relief.

šŸ’” Pro Tip: Keep a daily log of your dogā€™s behavior before and after starting the medication. This helps you track improvements over time and gives your vet valuable insights to adjust dosages or treatment plans if needed.


Comment 2: ā€œIs there a difference in how Pregabalin and Gabapentin work for seizures in dogs?ā€

Yes, while both Pregabalin and Gabapentin are anticonvulsants, there are differences in how they work for managing seizures in dogs. Pregabalin is a newer medication with greater potency, which means itā€™s often used when seizures are more difficult to control or when Gabapentin alone isnā€™t effective.

  • Pregabalin:Ā Known for itsĀ stronger binding affinityĀ to calcium channels in the brain, Pregabalin can stabilize electrical activity more efficiently. This makes it particularly effective in managingĀ refractory seizuresā€”those that donā€™t respond well to other medications. Its faster onset and longer duration of action also make it a better choice for dogs with more frequent or severe seizures.
  • Gabapentin:Ā While Gabapentin is commonly used for seizures, itā€™s more often prescribed as anĀ adjunctive therapy, meaning itā€™s used in combination with other anticonvulsants likeĀ PhenobarbitalĀ orĀ Keppra. It has a milder effect on controlling seizure activity compared to Pregabalin but is still a solid choice for less severe cases or when cost is a factor.
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šŸ’” Pro Tip: If your dogā€™s seizures are frequent or difficult to manage, switching from Gabapentin to Pregabalin may offer better control. However, seizure management is highly individual, so always consult your vet before making changes to your dogā€™s treatment plan.


Comment 3: ā€œCan I switch my dog from Gabapentin to Pregabalin, and whatā€™s the process like?ā€

Switching your dog from Gabapentin to Pregabalin is possible and can be beneficial if Gabapentin is no longer effective or if your dog needs more potent relief. However, this transition should be handled carefully to avoid withdrawal symptoms or ineffectiveness during the switch. Hereā€™s what you should expect:

  • Tapering Off Gabapentin:Ā Gabapentin should not be stopped suddenly, as doing so can causeĀ withdrawal symptomsĀ or even lead to rebound pain or seizures. Your vet will likely recommend gradually reducing the Gabapentin dosage over the course ofĀ several days to weeksĀ depending on your dogā€™s dose and how long theyā€™ve been on it.
  • Introducing Pregabalin:Ā At the same time, Pregabalin will be introduced at a low dose, which is gradually increased. Pregabalinā€™s potency means that itā€™s often administered atĀ lower dosesĀ than Gabapentin, so itā€™s crucial to follow your vetā€™s instructions carefully.
  • Monitoring for Side Effects:Ā As your dog adjusts to Pregabalin, watch for any changes in behavior, mobility, or side effects such asĀ excessive sedationĀ orĀ wobbliness. Pregabalin can cause more pronounced drowsiness initially, but this typically subsides as your dogā€™s body adapts to the new medication.

šŸ’” Pro Tip: Keep a close eye on your dogā€™s response during the transition. If you notice any concerning symptomsā€”such as increased lethargy, coordination issues, or gastrointestinal upsetā€”notify your vet immediately for a dose adjustment.


Comment 4: ā€œCan I use both Pregabalin and Gabapentin together for my dogā€™s pain management?ā€

Using both Pregabalin and Gabapentin together for pain management isnā€™t typically recommended because they function similarly and affect the same calcium channels in the brain. Combining the two could increase the risk of side effects like excessive drowsiness, ataxia (wobbliness), or gastrointestinal issues without offering significantly more pain relief.

However, in cases where one drug alone isnā€™t fully effective, combination therapy with other types of medications can be beneficial. Here are some common and effective combinations for managing complex pain:

  • Gabapentin + NSAIDs (like Carprofen or Meloxicam):Ā This is a common approach, especially forĀ arthritic painĀ or post-operative recovery. The NSAID reduces inflammation while Gabapentin addresses the nerve pain, creating a well-rounded pain management plan.
  • Pregabalin + Tramadol:Ā Tramadol is an opioid-like pain reliever often used for acute or severe pain, while Pregabalin targets the nerve pain component. This combination can be especially helpful for dogs recovering fromĀ orthopedic surgeriesĀ or those withĀ spinal issues.
  • Gabapentin + Amantadine:Ā For chronic conditions like arthritis or cancer pain, adding Amantadine to Gabapentin providesĀ enhanced reliefĀ by working on different pain pathways.

šŸ’” Pro Tip: Instead of using both Pregabalin and Gabapentin together, explore other multi-modal pain relief options. Always consult your vet to develop the most effective and safe combination for your dogā€™s specific needs.


Comment 5: ā€œCan Pregabalin or Gabapentin cause withdrawal symptoms in dogs if stopped suddenly?ā€

Yes, both Pregabalin and Gabapentin can cause withdrawal symptoms if they are stopped abruptly, particularly if your dog has been on the medication for a prolonged period or at higher doses. These medications alter the neurochemical balance in the brain, and sudden discontinuation can lead to the body reacting negatively.

Withdrawal symptoms can include:

  • Increased Anxiety or Agitation:Ā Your dog may become restless, anxious, or more reactive to stimuli.
  • Rebound Pain:Ā The nerve pain or discomfort the medication was treating may return suddenly, often more intense than before.
  • Seizures:Ā For dogs on Gabapentin or Pregabalin to control seizures, abrupt cessation can result inĀ seizure recurrence, sometimes more severe.

šŸ’” Pro Tip: Always taper down Pregabalin or Gabapentin doses gradually, under your vetā€™s guidance. This allows your dogā€™s system to adjust slowly and reduces the risk of withdrawal symptoms or rebound pain.


Comment 6: ā€œHow do Pregabalin and Gabapentin compare in terms of cost for long-term use?ā€

When considering long-term use, Gabapentin is the more affordable option compared to Pregabalin. While both medications require ongoing use for conditions like chronic pain or seizure control, Pregabalinā€™s newer formulation and greater potency come with a higher price tag. Hereā€™s how the two stack up:

  • Gabapentin:Ā Widely available and often theĀ first choiceĀ for long-term pain or seizure management due to its cost-effectiveness. Itā€™s available inĀ generic forms, which makes it much more affordable for extended use.
  • Pregabalin:Ā While more effective in some cases, Pregabalin is still under patent in many regions, making it more expensive. ItsĀ higher potencyĀ means your dog may need fewer doses, but the overall price per pill is significantly higher than Gabapentin.

šŸ’” Pro Tip: If cost is a concern and your dog is doing well on Gabapentin, it may be best to continue with that option. If Pregabalin is necessary for better control of symptoms, discuss potential discount programs or online pharmacy options with your vet to reduce the financial burden.

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Comment 7: ā€œCan these medications be used for other conditions besides pain and seizures?ā€

Yes, both Gabapentin and Pregabalin are versatile medications with uses beyond pain and seizure control. Here are some of the other conditions they may help manage:

  • Anxiety:Ā Gabapentin is sometimes prescribed for dogs withĀ anxiety disorders. It helps toĀ calm overactive nerves, making it useful for dogs with generalized anxiety, noise phobias, or stress related to vet visits or travel.
  • Cancer Pain:Ā For dogs dealing with pain fromĀ cancer, particularly neuropathic pain caused by tumors pressing on nerves, both Gabapentin and Pregabalin can provide significant relief. They are often part of aĀ palliative careĀ plan to improve quality of life.
  • Post-Operative Pain:Ā After surgeries, especially orthopedic procedures, these medications are used to manageĀ nerve-related discomfortĀ that might not be fully addressed by opioids or NSAIDs alone.

šŸ’” Pro Tip: If your dog struggles with anxiety or is facing chronic illness pain, ask your vet if Gabapentin or Pregabalin could be a suitable addition to their treatment plan for holistic symptom management.


Comment 8: ā€œMy dog seems very sedated on Gabapentin. Is this normal, and how can I manage it?ā€

Yes, sedation is a common side effect of Gabapentin, particularly during the initial stages of treatment or when the dosage is increased. This medication acts on the central nervous system, which can cause your dog to appear more lethargic or even overly sleepy. However, there are ways to manage this while ensuring your dog still receives the therapeutic benefits:

  • Start with a Lower Dose:Ā If your dog seems too sedated, speak to your vet about starting at aĀ lower doseĀ and gradually increasing it over time. A slow introduction allows your dogā€™s body to adjust to the medication and may help reduce the severity of sedation.
  • Adjust Timing:Ā Administering Gabapentin in the evening can help, as the sedative effects may occur overnight, allowing your dog to be more alert during the day. This is particularly useful if your dog needs to be active during certain parts of the day.
  • Monitor for Improvement:Ā Sedation often decreases as your dogā€™s body adjusts to the medication over the course of a week or two. If sedation persists or worsens, consult your vet aboutĀ alternative pain management strategiesĀ or different medications.
  • Split the Dosage:Ā Instead of giving one larger dose, splitting it intoĀ smaller dosesĀ spread out throughout the day can reduce the intensity of the sedative effect while still providing consistent pain relief or seizure control.

šŸ’” Pro Tip: Keep a close eye on your dogā€™s overall quality of lifeā€”if sedation is preventing normal activities like walking, eating, or playing, itā€™s crucial to discuss a revised dosing strategy with your vet to strike the right balance.


Comment 9: ā€œCan Pregabalin or Gabapentin be used alongside NSAIDs like Carprofen?ā€

Absolutely! In fact, combining Gabapentin or Pregabalin with NSAIDs (like Carprofen, Meloxicam, or Deracoxib) is a very common approach to managing chronic pain, especially for conditions like arthritis or post-surgical recovery. Hereā€™s why this combination works well:

  • Synergistic Pain Relief:Ā Gabapentin and Pregabalin targetĀ nerve pain, while NSAIDs addressĀ inflammatory pain. By using them together, you can tackle multiple pain pathways at once, offering more comprehensive relief for your dog.
  • Reduced Dosage of Each:Ā When used in combination, vets often find they can useĀ lower dosesĀ of each medication, which can help reduce the risk of side effects from either drug. This is particularly beneficial when trying to avoid the long-term side effects of NSAIDs, such as gastrointestinal or kidney issues.
  • Effective for Severe Pain:Ā For dogs experiencingĀ severe or complex pain, such as those recovering from orthopedic surgery or dealing with advanced osteoarthritis, this combo provides a more effective and long-lasting solution than either medication alone.

šŸ’” Pro Tip: Always follow your vetā€™s recommendations on dosing and monitor for side effects, especially when introducing NSAIDs. Signs like vomiting, diarrhea, or reduced appetite may indicate an issue, and your vet may adjust the medications accordingly.


Comment 10: ā€œHow does Gabapentin compare to Tramadol for pain management in dogs?ā€

Both Gabapentin and Tramadol are commonly prescribed for pain management, but they work in very different ways and are often used for different types of pain. Hereā€™s a detailed comparison:

AspectGabapentinTramadolšŸ’” Tip
Pain TypeBest for neuropathic pain, chronic conditions like arthritis or spinal issuesBest for acute pain (post-surgical, injury)Use Gabapentin for ongoing pain, Tramadol for short-term use.
Mechanism of ActionTargets nerve pain by affecting calcium channels in the brainOpioid-like medication, modifies pain perception in the brainConsider Tramadol for post-op pain, Gabapentin for long-term.
Sedation RiskModerate, more likely with higher dosesHigh, can cause significant drowsinessWatch for over-sedation with Tramadol, especially in older dogs.
Tolerance/DependenceLess risk of dependence or tolerancePotential for tolerance with long-term useTramadol should be used cautiously for prolonged periods.

Gabapentin is generally better suited for chronic pain management, especially if your dog is dealing with conditions like arthritis, intervertebral disc disease, or neuropathy. It works more gradually and is ideal for long-term use with fewer concerns about dependence.

Tramadol, on the other hand, acts more like an opioid, modifying how your dog perceives pain in the brain. Itā€™s typically prescribed for acute pain after surgery or injury but isnā€™t as effective for nerve pain or long-term use due to the bodyā€™s potential to build up tolerance over time.

šŸ’” Pro Tip: If your dog is experiencing both acute and chronic pain, your vet may prescribe both medications for a multi-modal approach. Always ensure that doses are given at the correct intervals to prevent sedation or other side effects.


Comment 11: ā€œIs Pregabalin worth the extra cost compared to Gabapentin for dogs with severe pain?ā€

When managing severe or chronic neuropathic pain, Pregabalin may be worth the additional cost due to its greater potency and longer-lasting effects. However, whether itā€™s worth the extra expense depends on your dogā€™s specific situation. Hereā€™s how to decide:

  • Greater Efficacy for Severe Pain:Ā If your dog is not responding adequately to Gabapentin, especially at higher doses, switching to Pregabalin could provideĀ better pain control. ItsĀ higher binding affinityĀ to calcium channels means it works more efficiently at controlling severe or refractory pain.
  • Fewer Doses Required:Ā Pregabalin typically requires fewer doses per day due to itsĀ longer duration of action, which can be more convenient for both you and your dog. Fewer doses may also help reduce the risk ofĀ missed doses, ensuring more consistent pain control.
  • More Potent, Faster Relief:Ā Pregabalinā€™s faster onset of action (within 30 minutes to 1 hour) can provide quicker relief for dogs in significant discomfort, making it aĀ better choiceĀ for managingĀ advanced arthritis,Ā cancer pain, orĀ post-surgical nerve pain.

However, Gabapentin remains a highly effective, more affordable option for many dogs, especially for those with mild to moderate pain. The cost-effectiveness of Gabapentin makes it an ideal starting point for most long-term pain management plans.

šŸ’” Pro Tip: If Pregabalin is being considered due to unmanageable pain with Gabapentin, talk to your vet about potential cost-saving programs or generic alternatives to help make the transition more affordable.


Comment 12: ā€œHow do I transition my dog off Gabapentin or Pregabalin if they no longer need it?ā€

Itā€™s important to avoid stopping Gabapentin or Pregabalin abruptly, as doing so can cause withdrawal symptoms, particularly if your dog has been on the medication for a long period or at higher doses. Hereā€™s how to transition safely:

  • Gradual Tapering:Ā Your vet will provide aĀ tapering schedule, where the dosage is slowly reduced over a period of weeks. This allows your dogā€™s system to adjust without causing a sudden resurgence of pain or withdrawal symptoms like restlessness or anxiety.
  • Monitor for Withdrawal Symptoms:Ā Signs of withdrawal can includeĀ increased sensitivity to touch,Ā restlessness, orĀ return of pain. If your dog shows any of these symptoms during the tapering process, itā€™s crucial to contact your vet. They may adjust the tapering schedule or recommend alternative pain management strategies.
  • Supplement with Other Pain Relief:Ā If your dog still requires some form of pain management, your vet might suggestĀ alternative medicationsĀ like NSAIDs, Amantadine, or even physical therapies such asĀ acupunctureĀ orĀ laser therapyĀ to help ease the transition off Gabapentin or Pregabalin.

šŸ’” Pro Tip: Ensure that tapering is done under veterinary supervision. Even if your dog seems to be improving, stopping the medication too quickly can lead to a relapse in pain or neurological issues. Keep track of any changes in behavior during this period to inform your vet.

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