FDA-approved dosing, weight-based dosage chart, tablet size guide, treatment duration, side effects, storage, and everything pet owners need to know about Clavamox for dogs.
Clavamox is a prescription-only antibiotic. Under U.S. federal law (21 CFR 558.15), Clavamox may only be used by or on the written order of a licensed veterinarian. Do not give your dog Clavamox leftover from a previous prescription, purchase it without a prescription, or adjust the dose without consulting your vet. The information in this guide reflects the FDA-approved package insert and is for educational reference — your veterinarian’s specific dosing instructions always take precedence. If you suspect an overdose, call ASPCA Animal Poison Control: 888-426-4435 or Pet Poison Helpline: 855-764-7661 (fee applies).
Clavamox (amoxicillin trihydrate/clavulanate potassium) is one of the most widely prescribed antibiotics in veterinary medicine for dogs and cats in the United States. Manufactured by Zoetis and FDA-approved under NADA 055-099 (tablets) and 055-101 (drops), it combines amoxicillin — a broad-spectrum penicillin-type antibiotic — with clavulanate potassium, a beta-lactamase inhibitor that enables the drug to kill bacteria that would ordinarily be resistant to amoxicillin alone. A 2021 FDA announcement also approved the first generic version of the oral suspension. Here are the 10 most important facts for dog owners whose pets have been prescribed Clavamox.
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What is the standard Clavamox dosage for dogs? 6.25 mg per pound (lb) of body weight · Given twice daily (every 12 hours) · Tablets and liquid drops use the same dose · For liquid drops: 1 mL per 10 lbs of body weight twice daily · Always based on your dog’s exact current weightThe FDA-approved standard dosage of Clavamox for dogs, per the official Zoetis package insert on DailyMed, is 6.25 mg per pound of body weight, administered orally twice daily (every 12 hours). For the liquid suspension (Clavamox Drops), this translates to 1 mL per every 10 lbs of body weight, twice daily. Both the chewable tablet and the oral suspension use the same per-pound dosing rate — your veterinarian will select the tablet strength or liquid volume that most closely meets your dog’s weight-based dose. Some veterinary references, including Plumb’s Veterinary Drug Handbook (10th Edition), note a dosing range of 6.875 mg/lb (13.75 mg/kg) for amoxicillin content specifically, reflecting slight differences in how the dose is calculated based on amoxicillin versus total compound weight. Your vet’s specific prescription instructions should always be followed precisely.
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What infections does Clavamox treat in dogs? FDA-approved uses: skin and soft tissue infections (wounds, abscesses, cellulitis, pyoderma) · Periodontal (gum/dental) infections · Off-label (vet-discretion): respiratory tract infections (lungs, sinuses, airways) · Does NOT treat Pseudomonas, Enterobacter, or viral/fungal infectionsPer the FDA-approved Clavamox package insert (DailyMed), Clavamox is indicated for dogs for: (1) skin and soft tissue infections including wounds, abscesses, cellulitis, superficial and juvenile pyoderma caused by beta-lactamase-producing Staphylococcus aureus, non-beta-lactamase-producing Staphylococcus aureus, Staphylococcus spp., Streptococcus spp., E. coli, and Pasteurella multocida; and (2) periodontal infections. Veterinarians may also prescribe Clavamox off-label for respiratory tract infections (off-label or extra-label use is permitted under FDA regulations when a vet determines it is in the patient’s best interest). Clavamox is not effective against Enterobacter or Pseudomonas species, and will not treat viral or fungal infections. A bacterial culture and sensitivity test may be performed to confirm the infection is susceptible before prescribing.
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What tablet sizes does Clavamox come in? Chewable tablets: 62.5 mg · 125 mg · 250 mg · 375 mg · All in a fixed 4:1 ratio of amoxicillin to clavulanate · 62.5 mg tablet = 50 mg amoxicillin + 12.5 mg clavulanate · Liquid drops: 62.5 mg per mL (50 mg amoxicillin + 12.5 mg clavulanate per mL)Clavamox chewable tablets are available in four strengths — 62.5 mg, 125 mg, 250 mg, and 375 mg — all in a fixed ratio of 4 parts amoxicillin to 1 part clavulanate. Breaking down each: the 62.5 mg tablet contains 50 mg of amoxicillin activity and 12.5 mg of clavulanic acid; the 125 mg tablet contains 100 mg amoxicillin + 25 mg clavulanate; the 250 mg tablet contains 200 mg amoxicillin + 50 mg clavulanate; and the 375 mg tablet contains 300 mg amoxicillin + 75 mg clavulanate. The oral suspension (Clavamox Drops) contains 50 mg of amoxicillin and 12.5 mg of clavulanic acid per mL (62.5 mg/mL total). Your veterinarian will prescribe the tablet strength or liquid volume that matches your dog’s weight. For very small dogs (under 10 lbs), the 62.5 mg tablet or the liquid drops are typically used. The 62.5 mg tablet is the only size approved for use in both dogs and cats; larger tablet sizes (125 mg and above) are for dogs only.
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How long does a dog need to take Clavamox? Superficial skin/soft tissue/periodontal infections: 5–7 days (or 48 hrs after symptoms clear) · No improvement after 5 days: stop and call vet for reevaluation · Deep pyoderma (deep skin infection): up to 21 days · Urinary tract infections (UTI): 10–14 days or longer · Maximum duration: 30 days · Always complete the full prescribed courseTreatment duration is determined by the type and severity of infection, per the FDA-approved package insert. Superficial skin infections, wounds, abscesses, cellulitis, juvenile pyoderma, and periodontal infections should be treated for 5–7 days, or for 48 hours after all symptoms have subsided — whichever comes last. If no improvement is seen within 5 days of starting treatment, the medication should be discontinued and the case reevaluated by your veterinarian. Deep pyoderma (deep skin infections) may require treatment for up to 21 days. Urinary tract infections may require 10–14 days or longer. The maximum duration of any Clavamox course should not exceed 30 days. Never stop the antibiotic course early just because your dog appears better — doing so can allow surviving bacteria to repopulate and develop resistance, potentially making future infections harder to treat.
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Should Clavamox be given with or without food? Can be given with OR without food · Giving with food strongly recommended to reduce vomiting · If your dog vomits after taking it on an empty stomach, give the next dose with food or a small treat · About 10% of dogs experience vomiting — food significantly reduces this riskThe official Clavamox package insert states the medication can be given with or without food. However, the same insert notes that gastrointestinal side effects — vomiting, diarrhea, and loss of appetite — may occur when given on an empty stomach. Clinical practice strongly favors giving Clavamox with a small amount of food or a treat to reduce stomach irritation. Approximately 10% of dogs experience vomiting as a side effect, and this rate decreases significantly when the medication is given with food. If your dog vomits after receiving Clavamox on an empty stomach, give all subsequent doses with food or a small treat. The chewable tablet formulation was specifically tested for palatability in field trials — 83% of dogs consumed the chewable tablet within 5 minutes when offered from a bowl or by hand, per the Clavamox Chewable label. If your dog refuses the tablet, it can be hidden in a pill pocket, soft treat, peanut butter, or small amount of cheese — ensure the entire tablet is consumed.
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What are the most common side effects of Clavamox in dogs? Most common: vomiting, diarrhea, loss of appetite · Usually mild and temporary · Less common: lethargy, drooling · Serious — see vet immediately: allergic reaction (difficulty breathing, hives, facial swelling, elevated heart rate, seizures, collapse) · Large overdose: can damage nervous system and liverMost side effects of Clavamox are gastrointestinal and relatively mild. Vomiting and diarrhea are the most frequently reported reactions, occurring in approximately 10% of treated dogs according to veterinary references. Loose stools and diarrhea result from the antibiotic altering the normal bacterial population of the intestine — this is common with all oral penicillin-type antibiotics. These effects are usually temporary and resolve when the course is finished. The most serious risk is an allergic reaction — Clavamox contains amoxicillin, a penicillin-type drug with known potential for allergic reactions. Signs of an allergic reaction in dogs include labored breathing, hives, rash, facial swelling, elevated heart rate, fever, seizures, drooling, and collapse. An allergic reaction is a veterinary emergency — seek immediate care. The treatment is epinephrine and/or corticosteroids. Overdose signs include vomiting initially; large overdoses can cause nervous system and liver damage per the FDA package insert.
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Which dogs should NOT receive Clavamox? Absolutely contraindicated: dogs with known allergy to penicillins or cephalosporins · Use with caution: pregnant or lactating dogs · Use with caution: dogs with kidney disease, heart disease, or dehydration · NEVER give to: rabbits, guinea pigs, chinchillas, gerbils, hamsters, or prairie dogs (can be fatal)The Clavamox package insert lists one absolute contraindication: dogs with a history of allergic reactions to any penicillin or cephalosporin antibiotic. Cross-reactivity between these antibiotic classes is documented, and a dog allergic to one penicillin should not be given another without careful veterinary evaluation. Use with caution is recommended in pregnant or lactating dogs — trace amounts of amoxicillin pass through the placenta and into breast milk, and the full implications for puppies are not well-characterized. Dogs with pre-existing kidney disease, heart disease, or significant dehydration should also be evaluated carefully before starting treatment, as these conditions can affect drug handling. An important warning from the package insert: Clavamox should never be given to rabbits, guinea pigs, chinchillas, gerbils, hamsters, or prairie dogs — these small animals can experience serious, potentially fatal reactions to penicillin-type antibiotics due to their unique intestinal flora.
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Does Clavamox interact with other medications? Known drug interactions: chloramphenicol (reduces effectiveness) · tetracycline antibiotics (may reduce effectiveness) · Always tell your vet every medication, supplement, and vitamin your dog receives · Probenecid can increase amoxicillin blood levels · Bacteriostatic antibiotics may reduce Clavamox effectivenessThe official Clavamox package insert and veterinary references identify two primary classes of medications that can interact with Clavamox: chloramphenicol and tetracycline antibiotics. Both of these are bacteriostatic antibiotics (they stop bacterial growth rather than killing bacteria directly), and combining them with Clavamox — which is bactericidal (kills bacteria) — may reduce overall effectiveness. This is because a bacteriostatic antibiotic slowing bacterial reproduction can interfere with the mechanism by which amoxicillin works. Probenecid, a medication used to treat gout, can slow kidney excretion of amoxicillin and increase its blood levels. Always provide your veterinarian with a complete list of all medications, supplements, vitamins, and herbal products your dog receives, including the dose and frequency — even products that seem harmless can interact with prescription antibiotics.
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How should Clavamox tablets and liquid drops be stored? Tablets: store at room temperature below 77°F (25°C) · Keep in foil blister packaging until ready to use · Keep out of humidity and direct light · Liquid drops: must be refrigerated after mixing with water · Use within 10 days of mixing — discard any remaining liquid after day 10 · Keep all Clavamox locked away from pets and childrenStorage is critically important for Clavamox, particularly the liquid suspension. Tablets: store in a dry, cool place at temperatures not exceeding 25°C (77°F). Do not remove tablets from the foil blister packaging until immediately before giving the dose — the foil packaging protects against moisture and humidity that degrades the medication. Clavamox Drops (liquid suspension): before mixing, the powder can be stored at room temperature. Once reconstituted (mixed with 14 mL of water as directed on the bottle), the suspension must be refrigerated and must be discarded after 10 days. The clavulanate component is chemically unstable and loses potency rapidly after reconstitution — giving liquid Clavamox past the 10-day mark risks providing an ineffective dose and not fully clearing the infection. Always write the date of mixing on the bottle. The package insert specifically warns: store Clavamox chewable tablets out of reach of dogs, cats, and other pets — the chewable tablet’s palatability means pets may eat the entire supply if they access it.
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What should I do if I miss a dose or my dog vomits one up? Missed dose: give it as soon as you remember · If it’s almost time for the next dose, skip the missed one and continue the schedule · Never give two doses at once · If your dog spits out or vomits the tablet within a few minutes: re-administer · If vomiting occurs regularly: tell your vet · Set twice-daily phone alarms to avoid missing dosesIf you realize you missed a scheduled Clavamox dose, give it as soon as you remember — unless it is already close to the time of the next scheduled dose. In that case, skip the missed dose entirely and resume the normal schedule with the next dose. Never give your dog two doses at once to make up for a missed one. Clavamox must maintain consistent blood levels to work effectively — this is why the twice-daily (every 12 hours) schedule is important. If your dog spits out or chews but doesn’t fully swallow the tablet, or vomits within minutes of receiving a dose, re-administer with a small amount of food to ensure the full dose is delivered. If vomiting consistently occurs within 30 minutes of dosing, contact your vet — there may be an alternative formulation or schedule that works better for your dog. Using a phone alarm set for every 12 hours is the most reliable way to maintain the correct dosing schedule throughout the treatment course.
Sources: DailyMed NLM NIH (Clavamox Chewable Tablets Zoetis 2020/2023; Clavamox Drops Zoetis; Amoxicillin/Clavulanate Potassium Suspension generic Cronus Pharma): 6.25mg/lb twice daily; tablet sizes 62.5/125/250/375mg; 4:1 ratio; drops 1mL/10lb twice daily; skin/soft tissue/periodontal 5-7 days; no response 5 days reevaluate; deep pyoderma 21 days; UTI 10-14 days; max 30 days; contraindicated penicillin/cephalosporin allergy; store tablets below 25°C; drops refrigerate after reconstitution; discard after 10 days; FDA CVM (fda.gov): NADA 055-099 tablets 055-101 drops; generic suspension approved 2021; prescription only; FDA Animal Drug FOI (animaldrugsatfda.fda.gov): 80% organism eradication; overdose CNS + liver; GoodRx pet health Aug 2025 (Plumb’s 10th Edition Wiley-Blackwell 2023; allergic reaction; antibiotic resistance); PetPlace (6.875mg/lb = 13.75mg/kg per Plumb’s; vomiting 10% dogs; chloramphenicol tetracycline interactions); BestiePaws Mar 2025 (storage tablet room temp; no OTC; full course warning); Wag! Aug 2020 / A-Z Animals Dec 2025 (missed dose; pregnant caution; kidney/heart caution; overdose signs; refrigerate liquid)
This chart reflects the FDA-approved standard dose of 6.25 mg/lb given twice daily from the official Clavamox package insert. Your veterinarian may adjust the dose based on your dog’s specific infection, health status, and kidney function. Always use the tablet strength and dose your vet prescribes — do not substitute based on this chart alone. Tablet doses shown represent the closest standard tablet size to the calculated dose without significantly exceeding it. Liquid dose = 1 mL per 10 lbs twice daily.
🔵 Clavamox Chewable Tablet Dosage by Dog Weight
| Dog Weight | Calculated Dose (6.25 mg/lb) | Tablet to Use | # Per Dose |
|---|---|---|---|
| 5 lbs | ~31 mg | 62.5 mg | ½ tablet |
| 10 lbs | ~63 mg | 62.5 mg | 1 tablet |
| 15 lbs | ~94 mg | 125 mg | ¾ tablet |
| 20 lbs | ~125 mg | 125 mg | 1 tablet |
| 25 lbs | ~156 mg | 125 mg | 1¼ tablets |
| 30 lbs | ~188 mg | 250 mg | ¾ tablet |
| 40 lbs | ~250 mg | 250 mg | 1 tablet |
| 50 lbs | ~313 mg | 375 mg | ¾–1 tablet |
| 60 lbs | ~375 mg | 375 mg | 1 tablet |
| 80 lbs | ~500 mg | 375 mg | 1 + ⅓ tablets |
| 100 lbs | ~625 mg | 375 mg | 1⅔ tablets |
🟢 Clavamox Drops (Liquid Suspension) — 1 mL per 10 lbs, Twice Daily
| Dog Weight | Liquid Dose Per Administration | Daily Total | Frequency |
|---|---|---|---|
| 5 lbs | 0.5 mL | 1.0 mL/day | Every 12 hrs |
| 10 lbs | 1.0 mL | 2.0 mL/day | Every 12 hrs |
| 15 lbs | 1.5 mL | 3.0 mL/day | Every 12 hrs |
| 20 lbs | 2.0 mL | 4.0 mL/day | Every 12 hrs |
| 30 lbs | 3.0 mL | 6.0 mL/day | Every 12 hrs |
| 40 lbs | 4.0 mL | 8.0 mL/day | Every 12 hrs |
🕐 FDA-Approved Treatment Duration by Infection Type
| Infection Type | Recommended Duration | Maximum |
|---|---|---|
| Superficial wounds, abscesses, cellulitis | 5–7 days (or 48 hrs past symptom resolution) | 30 days |
| Superficial / Juvenile pyoderma | 5–7 days (or 48 hrs past symptom resolution) | 30 days |
| Periodontal (gum/dental) infections | 5–7 days (or 48 hrs past symptom resolution) | 30 days |
| Deep pyoderma (deep skin infection) | Up to 21 days | 30 days |
| Urinary tract infection (UTI) | 10–14 days or longer | 30 days |
⚠️ No response after 5 days of treatment: discontinue and contact your veterinarian immediately for reevaluation.
Sources: DailyMed/NLM Clavamox Chewable Tablets Zoetis 2023 package insert (6.25mg/lb twice daily; tablet sizes 62.5/125/250/375mg; skin/soft tissue 5-7 days; deep pyoderma 21 days; max 30 days; UTI 10-14 days; no response 5 days reevaluate); DailyMed Clavamox Drops Zoetis (1mL/10lb twice daily; 50mg amoxicillin + 12.5mg clavulanate per mL); GoodRx pet health Aug 2025 (drops 1mL/10lb q12h confirmed; 5-7 days superficial)
Sources: DailyMed/NIH Clavamox package inserts (Zoetis Chewable 2023; Clavamox Drops); FDA CVM (fda.gov NADA 055-099/101)
Both formulations contain the same active ingredients and deliver the same dose — the choice depends on your dog’s size, temperament, and how easily they take medication:
- Chewable tablets (most dogs): Field testing by Zoetis showed 83% of dogs voluntarily ate the chewable tablet within 5 minutes. Tablets are easy to store (no refrigeration required), have a longer shelf life, and are the most convenient for larger dogs. The tablets can be broken in half if needed. Available in 62.5, 125, 250, and 375 mg strengths to match any dog’s weight. Palatable enough that the package insert specifically warns to keep the container out of pets’ reach to prevent accidental overconsumption.
- Liquid drops (small dogs, puppies, and dogs who refuse tablets): Ideal for very small dogs (under 5 lbs) where precise dosing is difficult with a solid tablet, and for puppies or dogs who consistently refuse to take pills. The liquid can be mixed into a small amount of food or administered directly with a syringe. Must be refrigerated after mixing and used within 10 days — requires consistent refrigeration.
- Generic liquid suspension: The FDA approved the first generic version of Clavamox Drops in 2021 (sponsored by Cronus Pharma Specialties). The generic contains the same active ingredients at the same concentrations and was confirmed to have no inactive ingredients that significantly affect bioavailability.
- Clavamox® (Zoetis): The original FDA-approved brand-name veterinary formulation of amoxicillin/clavulanate for dogs and cats. Available as chewable tablets and oral suspension drops. NADA 055-099 (tablets) and 055-101 (drops). The veterinary product specifically — manufactured, dosed, and labeled for dogs and cats.
- Clavacillin®: Another FDA-approved veterinary brand of amoxicillin/clavulanate for dogs and cats — same drug class and mechanism, different brand name. Contains the same 4:1 amoxicillin-to-clavulanate ratio. Available as tablets in 62.5, 125, 250, and 375 mg sizes. Functionally equivalent to Clavamox for most purposes.
- Augmentin® (GlaxoSmithKline): The human brand-name version of amoxicillin/clavulanate. The key difference: human Augmentin formulations vary in the ratio of amoxicillin to clavulanate (ranging from 2:1 to 7:1), whereas the veterinary product is always a fixed 4:1 ratio. Human Augmentin is sometimes prescribed off-label for dogs when veterinary formulations are unavailable, but dosing must be adjusted carefully because of the different amoxicillin-to-clavulanate ratio. Never substitute human Augmentin for Clavamox without explicit veterinary guidance on the correct dose adjustment.
- Generic amoxicillin/clavulanate suspension: FDA-approved generic equivalents exist following the 2021 FDA approval of the first generic. These contain the same active ingredients in the same concentrations as Clavamox Drops.
- Signs of improvement (should appear within 5 days): Reduced swelling and redness at infection sites, decreased pain response, reduced discharge from wounds, improved appetite and energy level, and clearer skin if treating pyoderma. Most dogs with superficial bacterial infections show meaningful improvement within 48–72 hours of starting Clavamox.
- If no improvement within 5 days: Per the FDA-approved package insert, if no response is seen within 5 days of starting treatment, the medication should be discontinued and the case reevaluated. The infection may be caused by a resistant organism, may require a different antibiotic, or the diagnosis may be incorrect. Contact your veterinarian promptly — do not simply continue giving Clavamox hoping for delayed improvement.
- Important note on antibiotic resistance: Using antibiotics when not needed, stopping a course early, or using subtherapeutic doses all contribute to antibiotic resistance — one of the most significant health threats in both human and veterinary medicine. The FDA package insert explicitly warns that prescribing antibiotics in the absence of a confirmed or strongly suspected bacterial infection provides no benefit and increases resistance risk. Only give Clavamox when prescribed by a veterinarian for a confirmed or suspected bacterial infection.
- After completing the course: Follow up with your veterinarian as recommended. For serious or deep infections, a recheck examination to confirm the infection has fully resolved may be appropriate — particularly for deep pyoderma, which may require a 21-day course.
Sources: DailyMed Clavamox Chewable (83% palatability field trial; tablet storage; keep from pets warning; 5-day reevaluation); FDA CVM fda.gov (generic suspension approved 2021 Cronus Pharma; first approved Feb 1986; NADA 055-099/101); GoodRx pet health Aug 2025 (Augmentin human ratios 2:1 to 7:1 vs veterinary 4:1; Clavacillin equivalent brand); A-Z Animals Dec 2025 (Clavacillin 62.5-375mg same tablet sizes; federal law vet order required); FDA NADA FOI (antibiotic resistance warning; prescribing absent confirmed infection increases resistance; 80% eradication rate clinical trial)
- Step 1 — Confirm the dose and schedule with your veterinarian. Verify the exact tablet strength, number of tablets per dose, and the twice-daily schedule before starting. Write it down. Set two phone alarms 12 hours apart as reminders to maintain consistent blood levels of the antibiotic.
- Step 2 — Always give with food. Giving Clavamox with a small amount of food or a treat significantly reduces the risk of vomiting. Do not give on an empty stomach unless your vet specifically instructs you to. If your dog refuses the tablet, hide it in peanut butter, a pill pocket, soft cheese, or a small piece of meat — ensure the entire tablet is consumed.
- Step 3 — Store correctly based on formulation. Tablets: store at room temperature below 77°F, in the foil packaging until use. Liquid drops: refrigerate immediately after mixing, and discard all unused liquid after 10 days. Write the mix date on the bottle. Giving expired or improperly stored liquid risks an ineffective dose and treatment failure.
- Step 4 — Complete the full course — never stop early. Even when your dog looks and feels completely better, finish every dose the vet prescribed. Stopping early leaves surviving bacteria that can repopulate — potentially with increased antibiotic resistance. If you notice no improvement after 5 days, contact your vet before continuing the medication.
This guide is independently researched for educational purposes only and does not constitute veterinary advice. All dosing information is based on the FDA-approved Clavamox package insert (Zoetis, DailyMed/NIH) and Plumb’s Veterinary Drug Handbook (10th Edition, 2023). Always follow your veterinarian’s specific dosing instructions — individual dogs may require adjustments based on the infection type, severity, weight, kidney function, and concurrent medications. Clavamox® is a registered trademark of GlaxoSmithKline, used under license by Zoetis Inc. Under U.S. federal law, Clavamox is available only by prescription from a licensed veterinarian. Do not use leftover antibiotics or purchase without a valid veterinary prescription.
Primary sources: DailyMed NLM NIH dailymed.nlm.nih.gov (Clavamox Chewable Tablets Zoetis 2023: 6.25mg/lb twice daily; sizes 62.5/125/250/375mg; 4:1 ratio; 62.5mg = 50mg amox + 12.5mg clav; 83% palatability trial; store below 25°C; foil until use; keep from pets; skin/soft tissue/periodontal 5-7 days or 48hrs; no response 5 days discontinue reevaluate; deep pyoderma 21 days; max 30 days; UTI 10-14 days max 30; contraindicated penicillin/cephalosporin allergy; WARNINGS store out of reach; caution pregnant/lactating; Clavamox Drops Zoetis: 6.25mg/lb = 1mL/10lb twice daily; 50mg amox + 12.5mg clav per mL; reconstitute 14mL water 15mL bottle; refrigerate; discard after 10 days; Amoxicillin/Clavulanate Potassium Suspension Cronus Pharma generic: same active ingredients same concentrations); FDA CVM fda.gov (FDA approves first generic amoxicillin/clavulanate oral suspension 2021 Cronus Pharma; same as Clavamox Drops first approved Feb 5 1986; NADA 055-099 tablets 055-101 drops; prescription only licensed vet federal law; skin/soft tissue wounds abscesses cellulitis dogs cats; periodontal dogs; UTI cats E. coli); FDA NADA FOI animaldrugsatfda.fda.gov (5/1.25mg/lb dosage FDA study; 80% organism eradication Clavamox vs 74% amoxicillin; overdose vomiting first sign; large overdose CNS + liver damage; epinephrine/steroids for allergy; ASPCA 888-426-4435 Pet Poison Helpline 855-764-7661); GoodRx pet health Aug 2025 DVM-reviewed (Plumb’s 10th Edition Wiley-Blackwell 2023; Zoetis 2023 package insert; 6.25mg/lb q12h; drops 1mL/10lb; max 30 days; allergic reaction; antibiotic resistance; chewable tablets and oral liquid forms); PetPlace.com (6.875mg/lb = 13.75mg/kg per Plumb’s; vomiting 10% dogs food reduces; chloramphenicol + tetracycline interactions; 62.5-400mg tablet range; 50mg/mL liquid); Brief Media Seattle Animal Shelter info sheet 2020 (FDA-approved dogs + cats; off-label respiratory; interactions chloramphenicol tetracycline; rabbits guinea pigs chinchillas gerbils hamsters prairie dogs fatal); BestiePaws Mar 2025 (storage room temp tablet; drops refrigerate after reconstitution; discard 10 days; full course; no OTC); Wag! Aug 2020 / A-Z Animals Dec 2025 (missed dose give ASAP; never double dose; overdose signs; liquid refrigerate; pregnant/lactating caution; kidney/heart disease caution; Clavacillin equivalent brand)