Benadryl for Dogs Dosage Chart mL

When it comes to giving your dog Benadryl, it’s crucial to understand the proper dosage. The liquid form of Benadryl has a concentration of 12.5 mg per 5 ml or 1 teaspoonful (tsp.).

How much benadryl to give a dog by weight

How many ml of liquid Benadryl can I give my dog?

A general rule of thumb is to administer 1 ml of Benadryl per 2.5 pounds of body weight. Therefore, if your dog weighs 25 pounds, the recommended dosage would be 10 ml or 2 tsp. However, it’s essential to note that this is a general guideline and may vary depending on the specific situation.

There are different forms of Benadryl available, including tablets, capsules, and liquid. The liquid form of Benadryl is generally considered the easiest to administer to dogs as it can be added to their food or water. However, it’s important to be aware of the concentration of the liquid and adjust the dosage accordingly.

Side effects of Benadryl for dogs

Here are some potential side effects that may occur when giving Benadryl to dogs:

  • Drowsiness: This medication is a sedative, so it’s not uncommon for dogs to become drowsy or even fall asleep after taking it. This can be beneficial if your dog is restless or anxious, but it’s important to be aware that it may affect their ability to stay alert.
  • Dry mouth: Benadryl can cause dry mouth in some dogs, which can lead to difficulty swallowing or even dehydration. It’s important to monitor your dog’s water intake and make sure they have access to fresh water at all times.
  • Digestive upset: Some dogs may experience stomach upset or diarrhea after taking Benadryl. If this happens, it’s important to stop giving the medication and talk to your vet about alternative options.
  • Urinary retention: Benadryl can cause urinary retention in some dogs, which can lead to difficulty urinating or even bladder infections. If you notice your dog having trouble going to the bathroom, it’s important to stop giving the medication and talk to your vet.
  • Allergic reactions: Like with any medication, there is always a risk of allergic reactions in some dogs. If you notice any signs of an allergic reaction, such as hives, swelling, or difficulty breathing, it’s important to seek immediate veterinary care.

How often can I give my dog Benadryl for itching?

As a general rule, Benadryl can be given to dogs every 8 to 12 hours as needed. However, the exact frequency will depend on factors such as your dog’s size, weight, and overall health.

If you notice that your dog’s itching is getting worse or if they experience any adverse side effects, stop giving them Benadryl and contact your vet right away.

Keep in mind that Benadryl is not a cure for itching and should not be used as a long-term solution. If your dog is experiencing chronic itching, your vet will likely recommend a more comprehensive treatment plan.

Never give your dog Benadryl without first checking with your vet, as it can interact with other medications they may be taking.

Just like with any medication, it’s always better to err on the side of caution and stick to the recommended frequency and dosage, rather than giving more thinking it will provide faster relief. Overdosing on Benadryl can lead to serious health problems, so be sure to follow your vet’s instructions.

Where to buy Benadryl for dogs

Benadryl is one of the most trusted brands in the market and can be a lifesaver for our four-legged friends. So, where can you get your paws on it? Let’s dive in!

First up, the most obvious choice is your local pharmacy. CVS, Walgreens, and Walmart all carry Benadryl in their pet section. Just be sure to check the label for the correct dosage for your pooch’s weight.

Another option is online shopping. Amazon, Chewy, and Petco have a wide range of Benadryl products for your convenience. Plus, you can have it delivered right to your door, making it a pawsitively purrfect option for busy pet owners.

If you prefer a more personalized shopping experience, you can visit a pet store near you. PetSmart and Pet Supplies Plus both have knowledgeable staff who can help you find the right product for your furry friend.

Lastly, don’t forget about your veterinarian. They can provide you with professional advice and also sell Benadryl products in their office. It’s a woof-tastic idea to get a second opinion from them before administering any medication to your pup.

In conclusion, there’s no shortage of options when it comes to buying Benadryl for your furry friend. Just remember to always follow the recommended dosage and check with your vet before starting any new medication. Happy shopping, and take care of your pupper!

Conclusion of liquid Benadryl for dogs


Benadryl, also known as diphenhydramine, can be used to treat a variety of conditions in dogs such as allergic reactions, motion sickness, and insomnia.

It is relatively inexpensive and widely available.

It is relatively safe for dogs when used as directed.


It can cause drowsiness and sedation in dogs, which may not be suitable for all dogs.

Overdose or long-term use can lead to serious side effects such as high blood pressure, seizures, and even death.

Some dogs may be more sensitive to the drug and may experience more severe side effects.

Side Effects:

Common side effects include drowsiness, dry mouth, and loss of appetite.

Less common side effects include increased heart rate, high blood pressure, seizures, and in rare cases, death.


Benadryl is considered relatively safe when used as directed. However, overdose or long-term use can lead to toxicity in dogs.

Drug Interactions:

Benadryl can interact with other medications, such as antidepressants and antihistamines. Therefore, it is important to inform your vet of all medications your dog is taking before administering Benadryl.


Benadryl should not be given to dogs with certain medical conditions such as glaucoma, hypertension, and prostate enlargement.

It should also be avoided in dogs with a history of seizures.

Research and Study:

Studies have shown that Benadryl is effective in treating allergic reactions and motion sickness in dogs.

However, more research is needed to fully understand the long-term effects of the drug on dogs.


Other antihistamines such as cetirizine and loratadine are also effective in treating allergic reactions in dogs.

Some veterinarians may also recommend alternative treatment options such as immunotherapy or corticosteroids for certain conditions.

It is important to always consult with a veterinarian before giving your dog any medication. They will help you weigh the pros and cons and determine the most appropriate treatment plan for your pet.


Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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