20 Best Gummies for Pain Relief

# Brand/Product CBD (mg) THC (mg) Key Botanicals Spectrum USDA Organic Vegan Price (30ct) Drug Test Safe? Best For
1 Aspen Green Relief Gummies 50 2.5 Turmeric, Ginger, Pepper Full Yes Yes $79.99 No Inflammatory/Arthritis Pain
2 Cornbread Hemp Extra Strength 100 4 Full Yes Yes $99.99 No Chronic/Severe Pain, Sleep
3 R&R Multifunctional Max Strength 90 <2.7 Full Yes Yes $100 No Severe, Persistent Pain
4 Medterra Max Relief 25 2 Full Ingredients Yes $34.99 No Daily Pain, Value
5 Neurogan Full Spectrum Gummies 120 <3.6 Full No Yes $75.00 No Very High Tolerance Pain
6 CBDfx Mixed Berry 25/50/100 ND Broad No Yes $54.99 Yes THC-Free Inflammatory Pain
7 Joy Organics Broad Spectrum 10/25 0.0% Broad Yes Yes $39.95 Yes THC-Free, Mild Daily Pain
8 Charlotte’s Web THC-Free 15 <0.01% Broad Yes (hemp) No ~$38.00 Yes Beginners, Sensitive Users
9 cbdMD Broad Spectrum Capsules 50/100/200 ND Broad No Yes N/A Yes High Potency, THC-Free
10 Alchemy Naturals Soothing Relief 25/50 <1.5 10mg CBG, Ginger Full No Yes $39.99 No Targeted Inflammation
11 Charlotte’s Web Recovery 10 (per 2) <0.3% Ginger, Turmeric Full Yes (hemp) No $34.99 No Exercise Recovery, Joints
12 CBDfx Turmeric & Spirulina 25 ND Turmeric, Spirulina Broad No Yes $54.99 Yes Antioxidant, Inflammation
13 Slumber Afternoon Delight 30 5 15mg CBG Full No Yes $60.00 No Nerve Pain, Daytime Focus
14 R&R CBD Pain Gummies 30 <0.9 5mg CBG, Devil’s Claw, Boswellia Full Yes Yes $65.00 No Osteoarthritis, Targeted Relief
15 Koi Anytime Balance 10 ND Broad No Yes $24.99 (20ct) Yes Mild Daily Pain, Value
16 FOCL Daily Calm Gummies 25/50 <1.5 Full No Yes $49.00 No Stress-Related Pain
17 Dad Grass Deluxe THC + CBD Gummies ~10 2 Full No N/A $55.00 No Mild Pain, Relaxation
18 SOUL Out of Office Gummies 45 10 Full No Yes N/A No Severe Pain, Mood Lift
19 Cornbread Blood Orange Bliss 10 10 Full Yes Yes $49.99 No Stress, Nighttime Pain
20 Charlotte’s Web Sleep Gummies 10 ND Melatonin, Lemon Balm Broad Yes (hemp) No $44.99 Yes Night Pain, Sleep Aid

🧠 Key Takeaways: Quick Consumer Questions Answered

QuestionShort Answer
What’s the best time to take pain relief gummies?Evening or post-exertion, unless they’re energizing (with CBG or citrus terpenes).
Can I mix these gummies with medications?Only with medical supervision. CBD and THC can interfere with liver enzyme function.
Why don’t I feel anything from CBD gummies?Possibly wrong dose, low-quality formulation, or individual metabolism mismatch.
Are all full-spectrum gummies psychoactive?No. Most contain microdoses of THC (≤0.3%)—non-intoxicating for most users.
What’s the difference between “pain” and “sleep” gummies?Sleep gummies often add CBN or melatonin—pain relief may be secondary.

🔬 Why Don’t These Gummies Work for Everyone?

It’s not the gummies—it’s your ECS, dose, and metabolism. Cannabinoid products interact with the endocannabinoid system (ECS) differently in each individual. If you don’t experience relief, it may be due to:

  • Low Bioavailability: Poor absorption from low-quality carriers or poor formulations.
  • Wrong Spectrum Type: CBD isolate lacks the synergy of full- or broad-spectrum blends.
  • Insufficient Cannabinoid Ratios: For example, pain from inflammation often requires more CBD + botanicals; nerve pain may need CBG or CBN.
🔍 Troubleshooting Chart
🧊 No relief at all? ➡ Try a higher dose or full-spectrum product.
🧪 Inconsistent effects? ➡ Check lab testing (COA) for potency variance.
🕒 Too slow to act? ➡ Consider tinctures or nano-emulsified gummies.
😴 Too sedating? ➡ Avoid products with CBN or high THC before daytime tasks.

🧪 What Makes a Gummy “High-Quality”? Most Don’t Meet the Bar.

You’d be shocked how many “wellness” brands don’t publish full COAs. A truly premium gummy must meet strict standards for potency, purity, and formulation transparency.

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🏆 Elite Quality Checklist
USDA Organic Hemp (e.g., Aspen Green, Cornbread Hemp)
Independent ISO 17025 Lab Testing (not in-house)
Comprehensive COA: Potency + Pesticides + Heavy Metals
Clean Ingredients: No artificial dyes, HFCS, or synthetic flavoring
Synergistic Additives: Botanicals like turmeric, ginger, boswellia

Gummies that check all these boxes? Only about 25% on the current market.


🌿 Why Minor Cannabinoids Matter More Than You Think

CBG, CBN, CBC, and others aren’t just buzzwords—they’re biochemical precision tools. Modern pain formulas rely on multi-cannabinoid synergy for targeted relief.

⚙️ Cannabinoid Roles in Pain Relief
🔬 CBD – Reduces inflammation, modulates pain signal transmission.
🧠 CBG – Inhibits Nav1.8 pain channel; good for nerve pain.
🌙 CBN – Calms the CNS; good for pain-related insomnia.
🎯 THC – Alters brain’s pain perception, even in microdoses.

Full-spectrum formulas (like Neurogan, Aspen Green) let these compounds amplify one another, boosting results.


💡 How to Choose the Right Gummy Based on Your Pain Type

Choosing a gummy should be like choosing a medication—specific to your condition.

🎯 Pain Type🧪 Best Cannabinoid Match🍬 Top Gummy
Inflammatory (Arthritis, Autoimmune)CBD + Turmeric + GingerAspen Green, R&R CBD Pain Gummies
Neuropathic (Fibromyalgia, Nerve)CBG + THC + CBDSlumber Afternoon Delight, Cornbread Hemp Extra
Post-Workout/RecoveryCBD + TurmericCharlotte’s Web Recovery
Stress-Related TensionCBD + CBN + L-theanineFOCL Daily Calm, Dad Grass Deluxe
Sleep-Interfering PainCBD + CBN or 1:1 THC:CBDCornbread Blood Orange Bliss, Soul Gummies

Tip: Always match the spectrum type and dosage to your activity level and symptom intensity.


🧭 Should You Be Worried About Failing a Drug Test?

If you’re in a regulated profession, the answer is yes—even federally legal gummies can cause positives. Here’s how to stay safe:

🚨 Risk Level by Product Type
🔴 Full-Spectrum (≤0.3% THC) – High risk for false positives.
🟡 Broad-Spectrum – No THC detected, but test error is possible.
🟢 Isolate – Safest choice for zero-THC assurance.

Key Tip: Always verify the COA for non-detectable THC. Don’t trust vague “THC-Free” labels.


🔄 When to Rotate or Adjust Gummies for Better Results

Cannabinoids can cause tolerance build-up over time. If your gummies stop working:

  • Switch spectrum types: from full to broad, or vice versa.
  • Try a different cannabinoid base: CBG instead of CBD.
  • Rotate botanicals: Ginger > Turmeric > Devil’s Claw.
  • Split doses: Morning and evening microdosing improves absorption.
🔁 Relief Strategy📍Change to Make
🛑 Plateaued reliefTry CBG-forward formulas
💤 Too sedatingDrop CBN or shift to daytime gummy
🧪 Gut sensitivitySwitch from gelatin to pectin-based vegan option
⏱️ Short effect windowUse sustained-release or softgel formulations

⚖️ Is the Price Worth It? What You Should Actually Pay Per MG

Cannabinoid gummies shouldn’t cost more than $0.05–$0.08 per mg of CBD unless they include minor cannabinoids, USDA Organic certification, or advanced botanicals.

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💰 Best Value Picks (2025)
Cornbread Hemp Extra Strength: $0.04/mg CBD, full USDA Organic, 4 mg THC
Medterra Max Relief: $0.05/mg, clean ingredients, widely available
CBDfx Mixed Berry (100mg): $0.04/mg, broad-spectrum high potency

Avoid overpriced “boutique” brands with $0.12+/mg unless backed by medical-grade certification.


🗝️ Final Recap: Expert Tips for First-Time Buyers

📌 Key Tip📋 Why It Matters
Start low, increase slowlyAvoid over-sedation or tolerance buildup.
Always read COAsEnsures what’s on the label is in the gummy.
Match formula to pain typeOne-size-fits-all = wasted money.
Avoid gummies with artificial junkPurity impacts bioavailability and results.
Verify spectrum type and THC contentEspecially if you’re subject to drug testing.

FAQs


💬 Q: “Why do full-spectrum gummies affect me more than expected, even with just 2–3 mg THC?”

Full-spectrum gummies include trace amounts of THC, but their effects can feel amplified due to the entourage effect—a synergistic interaction among cannabinoids and terpenes. THC may also bind more effectively in the presence of CBD, intensifying psychoactivity for some users even at legally low doses.

Important Factors:

🔍 Factor🧠 Why It Matters
Liver Enzyme EfficiencySlower metabolism means THC lingers longer, increasing impact.
Body Fat CompositionTHC is lipophilic, so it stores in fat and may accumulate.
Terpene InteractionTerpenes like myrcene can enhance THC’s sedative effects.
Time of Day TakenEvening use can feel stronger due to natural circadian rhythm shifts.

📝 Pro Tip: Consider spacing doses over 8–12 hours or switching to broad-spectrum to maintain relief while minimizing surprise psychoactivity.


💬 Q: “Can I take pain gummies daily without building up tolerance?”

Yes, but it depends on your cannabinoid rotation and dose discipline. Unlike opioids, cannabinoids don’t cause dangerous dependency, but receptor desensitization can blunt long-term efficacy.

How to Prevent Tolerance:

🔁 Strategy🔧 Explanation
Cannabinoid CyclingRotate between CBD, CBG, and THC every 2–3 weeks.
Dose IntervalsUse 5 days on / 2 days off weekly to reset ECS responsiveness.
Occasional ResetsGo THC-free for 1 week/month to reduce CB1 receptor saturation.

🧬 Bonus Insight: CBG appears to not desensitize receptors as aggressively as THC, making it a great option for baseline pain control.


💬 Q: “Why do some gummies help my joint pain but not nerve pain?”

Joint and nerve pain are biologically distinct. Joint pain is primarily inflammatory, while nerve pain stems from disrupted neural signaling. That’s why certain cannabinoid profiles work better for one than the other.

Targeted Cannabinoid Use:

🦴 Joint Pain🧠 Nerve Pain
✅ CBD + Turmeric + Ginger✅ CBG + CBD + Low-dose THC
💡 Reduces cytokines, prostaglandins💡 Modulates ion channels (e.g., Nav1.8), promotes neuroprotection
🧪 Example: Aspen Green Relief🧪 Example: Slumber Afternoon Delight

👨‍⚕️ Tip: If you have both types of pain, opt for multi-cannabinoid blends with 10+ mg CBG or add CBN for nighttime nerve repair support.


💬 Q: “What should I look for if I have autoimmune pain, like lupus or rheumatoid arthritis?”

You need ultra-clean, anti-inflammatory formulas that don’t overstimulate the immune system or introduce contaminants. Look for USDA Organic certification, non-GMO botanicals, and low sugar content.

Best Ingredients for Autoimmune Support:

🌱 Ingredient🛡️ Function
Full-Spectrum CBDModulates T-cell activity and lowers pro-inflammatory cytokines.
Curcumin (Turmeric)Inhibits NF-kB, a key player in autoimmune flare-ups.
BoswelliaReduces CRP levels, often elevated in autoimmune conditions.
Pectin-Based GummiesEasier on sensitive GI tracts than gelatin-based alternatives.

🛑 Avoid gummies with artificial dyes, corn syrup, or mystery flavorings—they may exacerbate immune reactivity.

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💬 Q: “Is it true that how I eat affects how my body absorbs gummies?”

Absolutely. Cannabinoids are fat-soluble, meaning they absorb better when taken with dietary fats. Eating a gummy on an empty stomach may result in slower onset and weaker effects.

Enhancing Bioavailability Naturally:

🍽️ Method🧪 Bioavailability Boost
Take with Omega-3s or AvocadoIncreases lymphatic absorption of cannabinoids.
Avoid High-Fiber Meals Right BeforeFiber may trap cannabinoids, delaying effects.
Chew ThoroughlyIncreases sublingual absorption, especially for pectin-based gummies.

🔥 Fast Fact: A study showed CBD absorption nearly quadruples when taken with a high-fat meal versus fasting.


💬 Q: “What should I do if gummies help my pain but make me sleepy during the day?”

You may be using a formula that favors sedative cannabinoids like CBN or THC-heavy ratios. Switching to CBG-forward gummies or daytime blends can maintain relief without mental fog.

Day-Friendly Gummy Formulas:

☀️ Ideal for Daytime💡 Reason
Slumber Afternoon DelightHigh CBG, balanced with CBD, very little THC.
CBDfx Mixed Berry (Broad-Spectrum)Energizing terpene profile, zero THC.
Joy Organics Broad-SpectrumLight and clear-headed with 10–25 mg CBD.

🕶️ Pro Move: For pain that intensifies midday, consider microdosing (cut gummies in halves/quarters) for steady support without a crash.


💬 Q: “I take CBD but still wake up stiff. Is it the wrong product or timing?”

Morning stiffness, especially related to arthritis or fibromyalgia, often results from overnight inflammatory buildup. CBD alone may reduce systemic inflammation, but it doesn’t always prevent nocturnal flare-ups unless combined with sleep-regulating cannabinoids or taken at an optimal time.

⏱️ Timing Strategy💊 Why It Works
Take 90 mins before bedAllows peak cannabinoid effect during deep sleep, when repair is most active.
Choose CBD + CBN or THCCombats pain + sleep cycle disruption, reducing AM tightness.
Split dose AM + PMSupports 24-hour anti-inflammatory coverage for chronic conditions.

🌙 Gummies like Cornbread Hemp Sleep or Soul Out of Office are formulated with balanced cannabinoid profiles to target this specific pain window.


💬 Q: “Can I combine CBD gummies with NSAIDs like ibuprofen?”

Yes, but with careful timing and awareness of liver enzyme load. CBD, like NSAIDs, is metabolized in the liver (CYP450 enzymes). Taking both simultaneously could increase plasma levels of either compound—potentially enhancing pain relief, but also side effect risk.

⚠️ Combination Guide
CBD + NSAIDs (6+ hrs apart) – Staggered intake minimizes enzymatic interference.
🔁 Alternate Days – Use CBD on low-pain days, NSAIDs on flare-up days.
🚫 Avoid with hepatotoxic drugs – Especially if taking methotrexate or high-dose acetaminophen.

🧪 Tip: Monitor for unusual fatigue or nausea—these may signal enzyme overload. Always consult your doctor if combining CBD with long-term pharmaceutical regimens.


💬 Q: “Which cannabinoids help with menstrual or endometriosis pain?”

Pain linked to hormonal cycles is often driven by prostaglandin-induced inflammation, uterine spasms, and mood instability. An ideal formula must balance anti-inflammatory, antispasmodic, and mood-regulating effects.

🌺 Cannabinoid/Herbal Combo for Cycle Pain
💚 CBD – Suppresses prostaglandin synthesis, easing cramps.
❤️ CBG – Reduces nerve sensitivity and gut cramping.
🌙 THC (microdose) – Calms uterine muscle spasms.
🍵 Botanicals – Look for chamomile, ginger, or chasteberry in relief blends.

🩸 Products like Alchemy Naturals Soothing Relief offer a thoughtful fusion of CBG, ginger extract, and full-spectrum CBD, tailored for hormone-sensitive inflammation.


💬 Q: “Why do some pain gummies taste bitter or grassy?”

Bitterness comes from natural hemp compounds, especially terpenes and flavonoids in full-spectrum products. It’s actually a sign of authenticity, not a defect—overly sweet gummies often use synthetic masking agents, which dilute efficacy.

🌿 Flavor Guide
🌾 Earthy/Bitter – Rich in terpenes and plant matter. Higher medicinal value.
🍬 Sweet/Fruity (no hemp taste) – Often isolate-based, lower in entourage effect.
🔥 Spicy notes (peppery) – Presence of beta-caryophyllene, a terpene with anti-inflammatory effects.

🧠 Consumer Hack: Check the ingredients. If it tastes too good to be true and lists “natural flavors” only, you’re likely getting a low-cannabinoid, high-sugar filler.


💬 Q: “What’s the best gummy for migraine-related pain?”

Migraine pain isn’t just vascular—it’s a neurological storm, often involving inflammation, serotonin imbalance, and trigeminal nerve hypersensitivity. A one-dimensional product won’t cut it.

💡 Migraine Relief Blend
CBD (25–50 mg) – Stabilizes neuroinflammation and reduces sensory overload.
CBG (10–15 mg) – Helps calm neuron excitability linked to aura symptoms.
🧴 No added dyes or artificial flavorings – Migraines are easily triggered by these.
🧘 Low THC (≤2 mg) – Helpful if photophobia or tension is severe, but avoid higher doses during acute phases.

🌐 Slumber Afternoon Delight or CBDfx Turmeric + Spirulina are strong choices. Their focus on neuro-calming botanicals makes them more effective than pure CBD isolates.


💬 Q: “Can I give pain gummies to my aging parent with arthritis?”

Yes—with precision. Seniors have slower metabolism, higher drug sensitivity, and may be on polypharmacy regimens. Choose low-dose, broad-spectrum options or microdose full-spectrum formulas with non-intoxicating THC levels.

👵 Senior Safety Chart
🍬 Start with 5 mg CBD – Gradually titrate to 25 mg max/day unless advised otherwise.
🌿 Broad-spectrum preferred – Avoids THC build-up, especially in cognitive disorders.
💧 Softgels may be easier – Better for those with dentures or difficulty chewing.
🔍 Essential: Check drug interactions – Especially with blood thinners, sedatives, or heart meds.

👂 Real-world note: Customers report that Joy Organics Broad Spectrum 10 mg is ideal for seniors—gentle, effective, and free from synthetic additives or THC.


💬 Q: “How do I know if a gummy is actually working or it’s placebo?”

Unlike sugar pills, high-quality cannabinoid gummies physiologically interact with ECS receptors, modulate inflammation, and influence serotonin and dopamine pathways. Still, perceived benefit varies, depending on baseline inflammation and neural sensitivity.

🔬 Signs Your Gummy Is Truly Working
🎯 Pain rating drops 2+ points within 30–90 mins.
🌙 Sleep improves without feeling heavily sedated.
🔁 Effects last 4–6 hours, suggesting real pharmacokinetic action.
🧍 Improved range of motion or tension release within joints/muscles.

💬 Pro Tip: Keep a symptom tracker log. Record gummy type, time of day, pain level, mood, and side effects. Over 1–2 weeks, patterns emerge that reveal true efficacy.


💬 Q: “How do pain gummies interact with antidepressants like SSRIs or SNRIs?”

Cannabinoids and SSRIs/SNRIs are both metabolized by liver enzymes—primarily the CYP450 system. CBD, in particular, can inhibit these enzymes, meaning antidepressant levels may rise, increasing both side effects and efficacy. While this interaction can sometimes improve mood stabilization, it can also trigger serotonin syndrome or amplify drowsiness.

⚠️ Interaction Hotspots💬 What to Watch For
CBD + Fluoxetine/SertralinePossible increase in fatigue, nausea, or anxiety if drug accumulates.
CBD + Venlafaxine/DuloxetineWatch for excessive sweating, confusion, or headaches.
THC + AntidepressantsCan unmask paranoia in sensitive individuals or worsen anxiety at higher doses.

🧠 Clinical pearl: Always start with the lowest possible gummy dose, and consult your prescriber before making changes. A weekly mood and symptom diary can help catch subtle shifts in medication effects early.


💬 Q: “Are there any gummies tailored for post-surgery pain that won’t interfere with wound healing?”

Some cannabinoids have anti-inflammatory and analgesic benefits without impairing tissue repair. Full-spectrum CBD gummies with low or no THC, enhanced with botanicals like ginger or boswellia, can manage pain while supporting the natural healing cascade. Avoid high-dose THC immediately after surgery, as it can impair immune modulation or increase sedation risk.

🩹 Post-Surgical Safe Picks🔑 Why
Medterra Max ReliefLow THC, potent CBD, promotes calm without sedation.
Alchemy Naturals Soothing ReliefCBG & ginger blend offers anti-inflammatory action, may reduce swelling.
Joy Organics Broad SpectrumTHC-free, gentle on the stomach, supportive for daily use.

🚫 Caution: Never use gummies to replace prescribed antibiotics or anticoagulants post-surgery—coordinate all supplement use with your surgical team.


💬 Q: “How can I use gummies for flare-ups in autoimmune diseases like Crohn’s, lupus, or MS?”

Autoimmune pain often presents in unpredictable waves. The best approach is to use broad-spectrum or full-spectrum gummies as “flare modulators,” not as daily immune suppressants. Choose products with strong anti-inflammatory terpenes (myrcene, beta-caryophyllene) and keep doses low at first, as high THC can sometimes trigger immune activation.

🦠 Autoimmune Flare Protocol🚨 Practical Tip
Start at 10 mg CBD + 2–5 mg CBGUse at first sign of flare (joint swelling, fatigue, GI cramping).
Avoid sugar-heavy or gelatin-based gummiesThese can worsen gut symptoms in Crohn’s or celiac overlap.
Combine with lifestyle: hydration, gentle movementGummies work best alongside anti-inflammatory routines.

💡 Pro Insight: If your autoimmune disease is stable, use gummies only as a rescue therapy, not as baseline maintenance, to reduce adaptation and maximize effectiveness.


💬 Q: “I have chronic neck and shoulder pain from desk work. What kind of gummies are best for tech neck?”

Tech neck and shoulder tension are a blend of muscle fatigue, micro-inflammation, and stress. Gummies that pair CBD (for inflammation) with small amounts of CBG (for muscle relaxation) work synergistically. Look for formulas labeled as “relief,” “focus,” or “calm” rather than strictly sleep-focused options.

🖥️ Best Office Gummy Solutions⌨️ Effect
FOCL Daily Calm (25 mg)Eases muscular tightness, sharpens mental clarity.
CBDfx Mixed Berry (Broad-Spectrum)Non-drowsy, manages inflammation, boosts daily resilience.
R&R Pain Gummies (30 mg CBD, 5 mg CBG)Potent enough for afternoon aches without cloudiness.

Extra hack: Combine gummies with ergonomic stretches and take a 2-minute “reset” walk every hour. Relief is maximized when cannabinoids are paired with physical mobility.


💬 Q: “Can gummies help with pain from endometriosis without affecting hormones?”

Endometriosis pain is uniquely challenging because it’s driven by both hormonal cycles and localized inflammation. Cannabinoids like CBD and CBG can target pain without binding to estrogen or progesterone receptors, so they don’t directly disrupt hormones.

🌸 Gummy Strategies for Endo Pain🤍 What to Look For
Full-spectrum CBD + ginger or turmericDiminishes prostaglandin-driven cramps.
CBG-rich optionsReduces nerve hypersensitivity, eases pelvic tension.
No added phytoestrogens or hormone mimicsEnsures clean support, safe for sensitive cycles.

🌱 Key advice: Use gummies during the worst pain days (not every day of your cycle) and track symptoms; over time, you may find the precise days they’re most effective.


💬 Q: “Do I need to worry about liver or kidney function with regular use?”

Moderate, high-quality CBD use is generally safe for healthy adults, but anyone with liver or kidney disease should consult their physician. Cannabinoids and some pain-relief botanicals are metabolized by the liver—rare cases of elevated liver enzymes have been reported at high doses (especially with CBD isolates).

🏥 Monitoring Chart🧬 When to Check Labs
History of hepatitis, cirrhosis, or renal impairmentBaseline and annual liver/kidney panels.
Using >50 mg CBD/day for more than 3 monthsTest after 1–2 months, then every 6 months.
Taking other liver-metabolized meds (statins, anticonvulsants)Quarterly review with healthcare provider.

🚦 Red Flag: Unexplained fatigue, jaundice, or dark urine—stop use and seek prompt medical advice.

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