Heartworm Pills PetSmart

Heartworm prevention is an important aspect of pet care, as heartworm disease can be deadly for dogs and cats. One way to prevent heartworm disease is to give your pet a monthly heartworm preventive pill. PetSmart is a popular retailer that carries a wide variety of heartworm preventive pills for dogs and cats.

Advantage Multi for Dogs: A once-a-month topical solution for dogs 7 weeks or older and at least 3 lbs that prevents heartworm and treats hookworms, roundworms, whipworms, and fleas. Not safe for breeding, pregnant, or lactating dogs and should not be ingested.

Capstar: An oral tablet used in dogs 4 weeks or older that starts killing adult fleas within 30 minutes and shows 90% effectiveness within 4 hours. Does not affect fleas in the environment.

Comfortis: A monthly chewable tablet for dogs 14 weeks or older that starts killing fleas 30 minutes after administration.

Droncit: Available in tablet or injectable form for removing tapeworms in dogs and is safe for breeding and pregnant dogs.

Drontal Plus: A tablet for removing tapeworms and hookworms, roundworms, and whipworms in dogs. Not for use in pregnant animals, puppies under 3 weeks old, or dogs weighing under 2 lbs.

Frontline Plus for Dogs: A spot treatment for controlling ticks, chewing lice, and fleas in dogs 8 weeks or older. Can be used on breeding, pregnant, and lactating bitches but not on rabbits.

Frontline Spray: A spray for controlling fleas, ticks, and chewing lice in dogs, used no more frequently than every 30 days. Consult a vet before use on medicated, debilitated, aged, pregnant, or nursing animals. Not for use on puppies under 8 weeks or on rabbits.

PetSmart offers a wide variety of heartworm preventive pills for both dogs and cats, including options that also control other parasites such as fleas and hookworms. Consult with a veterinarian to make sure you choose the right heartworm prevention treatment for your pet and follow the instructions provided on the medication label or by the veterinarian to ensure your pet’s optimal health.


Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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