Where to Buy Benadryl for Dogs


  • Product: Benadryl Extra Strength Cooling Anti-Itch Spray
  • Manufacturer: Johnson & Johnson
  • Brand: Benadryl®
  • Active Ingredients: Diphenhydramine HCI 2%, Zinc acetate 0.01%
  • Inactive Ingredients: Alcohol, glycerin, PVP, purified water, tromethamine
  • Indications:
    • Itching
    • Hives
    • Rash
    • Insect bite
  • Pack size: 2 fl. Oz Spray


Benadryl may be prescribed by your veterinarian if an allergic reaction occurs. This medication will help stop the itching and relieve your dog’s discomfort. This article will provide you with an overview of Benadryl for dogs: dosage, side effects, and where to buy.

Where to buy Benadryl for dogs

Can I give my dog Benadryl?


  • Benadryl, also known as diphenhydramine, is an antihistamine that can be used to treat a variety of conditions in dogs, including allergies, anxiety, and motion sickness.
  • It is available over the counter and is relatively inexpensive.
  • In most cases, it is considered safe for use in dogs, with few side effects reported.


  • Before giving your dog Benadryl, it is important to consult with your veterinarian to determine the appropriate dosage and frequency of administration.
  • Giving your dog too much Benadryl can cause drowsiness, dry mouth, and other side effects.
  • Some dogs may be more sensitive to the medication and may experience more severe side effects.
  • It is not recommended to give Benadryl to dogs who have certain medical conditions such as glaucoma, hypertension and or have a history of prostate disorders.
  • It is also not recommended to give Benadryl to pregnant or nursing dogs.

It’s important to note that giving your dog Benadryl should only be done under the guidance of a veterinarian. While it can be a helpful medication in certain situations, it is not a substitute for proper medical care. In case of an emergency, it’s best to seek immediate help from a veterinarian.

Where can I buy Benadryl for dogs?

Here are a few options for where you can purchase Benadryl for dogs near you.

  1. Local Pet Stores – Many pet stores carry a variety of medications for dogs, including Benadryl. Be sure to check with your local pet store and ask if they carry the medication. Some popular pet store chains that carry Benadryl include Petco and PetSmart.
  2. Online Retailers – If you prefer to shop online, there are a number of online retailers that sell Benadryl for dogs. Some popular online retailers include Amazon, Chewy, and PetMedExpress. Be sure to read the product description and reviews before making a purchase to ensure that you are getting the right product for your dog.
  3. Veterinarian’s Office – Your veterinarian may also carry Benadryl for dogs. If they do not carry it in-house, they may be able to order it for you. It is important to note that you will need a prescription from your veterinarian to purchase Benadryl from their office.
  4. Pharmacies – Some pharmacies may carry Benadryl for dogs, but it is important to note that not all pharmacies carry this medication. It is best to call ahead to your local pharmacy and ask if they carry Benadryl for dogs.

How much Benadryl can I give my dog chart

The standard dosage for Benadryl for dogs is 1mg/pound of body weight. This means that for a 25-pound dog, the recommended dosage would be 25mg. It is important to note that this dosage should not be exceeded, as it can cause adverse side effects such as drowsiness, dry mouth, and increased heart rate.

When administering Benadryl to your dog, it is recommended to use the liquid form of the medication as it is easier to measure accurate dosages. The liquid form of Benadryl can be administered orally or added to your dog’s food. If your dog is reluctant to take the medication, you can try mixing it with a small amount of wet food to make it more palatable.

Dog’s weight (lbs) Benadryl dosage (tablet)
5 lbs 1/2 tablet of 12.5 mg
10 lbs 1 tablet of 12.5 mg
20 lbs 1 and 1/2 tablets of 12.5 mg
30 lbs 1 tablet of 25 mg
40 lbs 1 and 1/2 tablets of 25 mg
50 lbs 2 tablets of 25 mg
60 lbs 1 tablet of 50 mg
70 lbs 1 and 1/2 tablets of 50 mg
80 lbs 1 and 1/2 tablets of 50 mg
100 lbs 2 tablets of 50 mg

Benadryl for dogs dosage chart ml

The BENADRYL® Liquid contains 2.5 mg of Diphenhydramine per ml so if your pet weighs 25 pounds he will need one tablet of 25 mg or 10 ml which equals 2 teaspoons.

Dog’s weight (lbs) BENADRYL® Liquid dosage (ml)
10 lbs 4 ml
20 lbs 8 ml
30 lbs 12 ml
40 lbs 16 ml
50 lbs 20 ml
60 lbs 24 ml
70 lbs 28 ml
80 lbs 32 ml
90 lbs 36 ml
100 lbs 40 ml

Customer reviews

The Benadryl reviews are mostly positive, but there are some complaints.

“I have been using Benadryl for dogs for years. It works wonders on my dog’s allergies and keeps her comfortable all day long. She is a big girl and can be a handful when it comes to the allergy season.”

“I have a small dog that has a very sensitive stomach and skin issues, so I’ve tried several different things to help him feel better. I found this product at the store, so I decided to give it a try. It worked fantastically!”

“This stuff really works great! My dog’s allergies were very bad this year, so we tried everything under the sun. This really helped him get over his skin issues and he didn’t have any more symptoms after using this product.”

“This is an excellent product. My dogs are very allergic to fleas and ticks, so I’ve been using this product for the past 6 months. I noticed a huge difference in their health within the first week of use. They no longer scratch themselves as much, their coats are shiny and soft, and they’re not scratching themselves in the house as much either. It’s great!”

” I have a little dog who is allergic to everything. I was so happy to find Benadryl for dogs, but it doesn’t seem to work at all for him. He does not sneeze or itch, just like before he was on Benadryl. I am very disappointed in this product and would not recommend it to anyone else.”

“I have been using Benadryl for my dogs for years. I have tried other products but they do not work as well as Benadryl. It is easy to give them, has no side effects and they love it! I love that I can get them at a reasonable price, plus the shipping is so fast.”

What are the side effects of giving a dog Benadryl?

Here are some potential side effects that may occur when giving a dog Benadryl, also known as Diphenhydramine.

  • Drowsiness and sedation: One of the most common side effects of Benadryl is drowsiness and sedation. This is due to the drug’s antihistamine properties, which can cause a relaxed and sleepy state. While this may be beneficial for dogs with anxiety or restlessness, it can also make them less alert and responsive.
  • Dry mouth and eyes: Benadryl can also cause dry mouth and eyes in dogs. This is because the drug can reduce the production of saliva and tears, leading to discomfort and potential infections.
  • Loss of appetite: Some dogs may experience a loss of appetite after taking Benadryl. This can be due to the drug’s sedative effects, which can make them less interested in food.
  • Constipation: Benadryl can also cause constipation in dogs, which can be uncomfortable and painful. This is due to the drug’s drying effects on the gastrointestinal tract, which can slow down the movement of food and waste through the body.
  • Behavioral changes: Some dogs may experience behavioral changes after taking Benadryl, such as agitation or disorientation. These side effects can be due to the drug’s sedative properties, which can affect a dog’s ability to react.
  • Allergic reactions: Rarely, dogs may have an allergic reaction to Benadryl. This can include symptoms such as hives, itching, swelling, and difficulty breathing. If a dog experiences any of these symptoms, it is important to seek immediate medical attention.

Apoquel vs Benadryl for dogs?

Both have their own benefits and drawbacks, and it is important to consider these when deciding which treatment plan to use for your pet.

Apoquel (oclacitinib tablet) is a targeted therapy that works by inhibiting specific steps in the pathway that produces itching and inflammation in dogs with atopic and/or allergic dermatitis. It is a JAK enzyme inhibitor that selectively targets JAK-1-dependent pruritogenic, proallergic, and pro-inflammatory cytokines. This medication stops itching and inflammation at the source by suppressing transmission of chemical signals that lead to clinical signs in dogs with atopic and allergic dermatitis. Apoquel starts to relieve allergic itch within 4 hours, significantly controls itch within 24 hours, and, with continued use, relieves inflammation and improves skin lesions. It can be used concurrently with other medications and is easy for pet owners to use, with once-daily therapy. The most common adverse events were vomiting and diarrhea.

Benadryl (diphenhydramine) is an antihistamine medication that is commonly used to relieve itching and other symptoms associated with allergies in dogs. It works by blocking the effects of histamine, a chemical that is released in response to an allergen. However, antihistamine monotherapy is frequently ineffective, as it is primarily the key cytokine mediators that are causing the pet’s itch and inflammation. According to the International Committee on Allergic Diseases of Animals, antihistamines offer little or no benefit in treating flares of canine atopic dermatitis. Additionally, antihistamines tend to cause drowsiness, which some pet owners find objectionable.

In conclusion, Apoquel is a targeted therapy that works by inhibiting specific steps in the pathway that produces itching and inflammation in dogs with atopic and/or allergic dermatitis. It is generally considered to be more effective and have fewer side effects than Benadryl. However, it is also more expensive and may not be covered by all pet insurance plans. Ultimately, the choice between these two medications will depend on your pet’s specific needs and your budget. It is always best to consult with your veterinarian to determine the best treatment plan for your furry companion.

Conclusion of Benadryl for dogs


  • Benadryl is an inexpensive and easily accessible over-the-counter medication.
  • It is commonly used to treat a variety of conditions in dogs, including allergic reactions, anxiety, and motion sickness.
  • It is a sedative, which can be helpful for dogs with anxiety or agitation.


  • Benadryl is not always effective for treating allergic reactions in dogs, and its effectiveness can vary among individual dogs.
  • It may cause drowsiness, which can be a problem for dogs who need to be active or alert.
  • Long-term use of Benadryl can lead to side effects such as dry mouth, constipation, and confusion.

Side Effects:

  • Drowsiness, sedation, and fatigue are the most common side effects of Benadryl in dogs.
  • Other side effects may include dry mouth, constipation, confusion, and urinary retention.
  • Benadryl can also cause behavioral changes in some dogs, such as restlessness or agitation.


  • Benadryl is considered to be relatively safe for use in dogs, but it can be toxic if given in large doses.
  • Signs of overdose include drowsiness, dry mouth, urinary retention, and confusion.
  • If your dog has accidentally ingested a large amount of Benadryl, contact your veterinarian immediately.

Drug Interactions:

  • Benadryl may interact with other medications your dog is taking, such as sedatives, antidepressants, and blood pressure medications.
  • It is important to inform your veterinarian of all medications your dog is taking before starting treatment with Benadryl.


  • Benadryl should not be used in dogs with certain medical conditions, such as glaucoma, hypertension, and prostate enlargement.
  • It should also be avoided in dogs who are pregnant or nursing.

Research and Study:

  • Studies have shown that Benadryl can be effective in treating allergic reactions and anxiety in dogs, but its effectiveness can vary among individual dogs.
  • More research is needed to fully understand the efficacy and safety of Benadryl for dogs.

Natural or OTC Veterinary Alternatives:

  • Some natural alternatives to Benadryl for dogs include herbs such as chamomile, passionflower, and valerian root.
  • Other over-the-counter options for treating allergic reactions and anxiety in dogs include antihistamines such as cetirizine and loratadine.
  • It is important to consult with a veterinarian before trying any alternative treatments for your dog.


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