Advantage Multi Vs. Revolution Plus for Cats

When it comes to parasite treatments for your feline friend, you’ve likely heard of Advantage Multi and Revolution Plus. Both products have robust reputations and have been highly recommended by veterinarians for effective parasite control. But when faced with a choice, which one should you opt for? This article will delve into a detailed comparison of Advantage Multi and Revolution Plus, discussing their similarities, differences, and everything else you need to make an informed choice for your pet.

Similarities: The Common Grounds

Before we explore the differences, let’s highlight what these two power-packed treatments have in common.

  • Broad Spectrum Protection: Both Advantage Multi and Revolution Plus provide broad spectrum protection. They are effective against adult fleas, flea larvae, heartworms, and intestinal worms. This dual action makes them a comprehensive choice for pet owners seeking protection from a range of parasites.
  • Topical Application: Both treatments are topical, meaning they’re applied to the skin. This ensures quick absorption and rapid action against parasites. It also makes them easy to administer without the struggle of trying to get your cat to swallow a pill.
  • Monthly Application: Advantage Multi and Revolution Plus are designed for monthly application, providing lasting protection and convenience.

Advantage Multi: The Double Action Hero

Advantage Multi contains two active ingredients, Imidacloprid and Moxidectin, that tackle both external and internal parasites.

  • Imidacloprid is a potent insecticide that effectively eliminates adult fleas by attacking their nervous system, thus preventing further infestations.
  • Moxidectin, on the other hand, is an antiparasitic agent that kills heartworm larvae and intestinal worms.

Advantage Multi’s dual action approach provides comprehensive protection against a host of parasites. However, it is not indicated for tick protection, nor does it cover ear mites.

Revolution Plus: The Six-in-One Shield

Revolution Plus is a more recent introduction to the feline parasite treatment market and boasts of a six-in-one protection. It’s a combination of two active ingredients, Selamectin and Sarolaner.

  • Selamectin protects against fleas, heartworms, roundworms, and ear mites. It also treats and controls hookworms, making it an effective option for managing various external and internal parasites.
  • Sarolaner, the added ingredient in Revolution Plus, helps protect against ticks, a feature not present in the original Revolution product or in Advantage Multi.

The comprehensive protection that Revolution Plus provides, covering a wide range of both external and internal parasites, including ticks, sets it apart.

A Deeper Look into Active Ingredients

Both Advantage Multi and Revolution Plus utilize a combination of potent active ingredients to ward off and eliminate parasites.

Advantage Multi harnesses the power of Imidacloprid, a potent insecticide, which disrupts the nervous system of fleas, leading to their demise. It works effectively to kill adult fleas and prevents further infestations by targeting larvae. The second key ingredient in Advantage Multi is Moxidectin, an antiparasitic agent. Moxidectin’s primary role is to tackle internal parasites, eradicating heartworm larvae and a variety of intestinal worms.

On the other hand, Revolution Plus combines Selamectin and Sarolaner to provide a six-in-one shield against parasites. Selamectin is effective against a multitude of parasites including fleas, heartworms, roundworms, hookworms, and ear mites, providing broad-spectrum coverage. The inclusion of Sarolaner, which specifically targets ticks, makes Revolution Plus stand out from other treatments, including Advantage Multi.

Application and Dosage

Advantage Multi and Revolution Plus both come in easy-to-use topical formulations. The treatments are applied directly to the skin, which allows for quick absorption and rapid onset of action against parasites. The liquid is typically applied between the shoulder blades of the cat where it’s difficult for them to lick it off.

Both treatments are designed to be administered monthly, which offers lasting protection and ease for pet owners. However, the precise dosage depends on the weight of your cat. It’s vital to use the correct dosage as recommended by your veterinarian to ensure the safety and efficacy of the treatment.

Possible Side Effects

While both products are generally well-tolerated, some cats might experience side effects. Some common side effects of Advantage Multi include temporary hair loss at the application site, loss of appetite, and excessive salivation. In rare cases, neurological signs such as uncoordinated movement and seizures have been reported.

In the case of Revolution Plus, potential side effects could include temporary hair loss or skin irritation at the application site, lethargy, decreased appetite, or diarrhea. Though rare, severe reactions including seizures can occur.

Environmental Considerations

The living environment and lifestyle of your cat play a crucial role in the selection of a suitable flea and parasite treatment. If your cat spends a significant amount of time outdoors, they might be at greater risk of encountering a wider variety of parasites, including ticks. In this case, Revolution Plus, with its added tick protection, could be a more fitting choice.

However, if your cat is strictly an indoor pet with little to no exposure to ticks, Advantage Multi might suffice for parasite protection. Remember, it’s essential to have a conversation with your vet to consider all environmental factors and choose the most appropriate protection for your feline friend.

Cost Considerations

While the health of your cat is a priority, the cost may also factor into your decision. Generally, Revolution Plus is more expensive than Advantage Multi due to its broader range of protection, including ticks. However, prices can vary, so it’s recommended to check with your local veterinary clinic or trusted online pet pharmacy for the most current pricing.


Neither Advantage Multi nor Revolution Plus should be used in kittens younger than eight weeks old. Both treatments require an accurate weight for correct dosing, so they may not be suitable for very small kittens. Always consult your vet before beginning any new treatment regimen.

Final Thoughts: Making the Right Choice

The choice between Advantage Multi and Revolution Plus comes down to your cat’s specific needs, lifestyle, and the recommendation of your veterinarian. Both products offer broad-spectrum protection against common parasites. If your cat spends a lot of time outdoors and is at risk of tick exposure, Revolution Plus might be a more suitable choice due to its tick protection.

However, remember that every cat is unique, and individual responses may vary. Consult with your veterinarian to decide which treatment will work best for your feline friend. The ultimate goal is to keep your cat healthy, happy, and parasite-free. Whichever product you choose, your cat will be well-protected against a variety of common parasites.

FAQs: Decoding the Details of Advantage Multi and Revolution Plus

Q1: Can I use Advantage Multi or Revolution Plus for my kitten?

A: For both products, it’s essential to ensure your kitten is of the appropriate age and weight. As a general guideline, both treatments can be used for kittens aged eight weeks and older. However, it’s crucial to consult your veterinarian before starting any new medication or treatment regimen with your kitten. The dosage will depend on your kitten’s weight, so it’s important to have accurate measurements.

Q2: Can I use Advantage Multi or Revolution Plus if my cat is pregnant or lactating?

A: Both Advantage Multi and Revolution Plus are considered safe to use on pregnant and lactating cats. But, as always, you should discuss this with your veterinarian before beginning or continuing treatment during pregnancy or nursing to ensure the safety of both the mother and her kittens.

Q3: How quickly do Advantage Multi and Revolution Plus work?

A: Advantage Multi and Revolution Plus both start working quickly after application. Advantage Multi begins killing fleas within 12 hours of application. Revolution Plus starts killing fleas within 6 hours and ticks within 24 hours of application. Both treatments require monthly reapplication to maintain their effectiveness.

Q4: What should I do if I miss a dose?

A: If you miss a dose, it’s recommended to apply the treatment as soon as you remember, and then continue with the regular monthly schedule. It’s essential to maintain consistent protection, so try setting reminders to help you remember the monthly applications.

Q5: Can I bathe my cat after applying Advantage Multi or Revolution Plus?

A: For both products, it’s generally recommended to avoid bathing your cat for at least 24-48 hours after application. This allows the treatment to fully absorb and distribute across your cat’s skin. After that, occasional bathing or swimming should not affect the efficacy of the product.

Q6: Are there any interactions with other drugs?

A: While both Advantage Multi and Revolution Plus are generally considered safe, interactions with other drugs are always a possibility. If your cat is currently on any other medication, it’s important to discuss this with your veterinarian before starting a new treatment.

Q7: What if my cat experiences side effects?

A: If you notice any adverse reactions or side effects after applying either treatment, such as excessive scratching, redness, vomiting, or unusual behavior, it’s important to contact your veterinarian immediately. In rare cases, severe reactions can occur.

Q8: Can I use Advantage Multi or Revolution Plus on other pets?

A: Advantage Multi and Revolution Plus are specifically formulated for cats, and the dosages are based on feline weight. Using these treatments on other types of pets, such as dogs or rabbits, can lead to incorrect dosing and potential health issues. Always use pet medications as directed and consult with a veterinarian before applying to other species.

Q9: Can my cat still get fleas or ticks after treatment?

A: While Advantage Multi and Revolution Plus are highly effective, no treatment can guarantee 100% protection. Your cat may still pick up fleas or ticks in heavily infested environments. However, these treatments should kill parasites before they can reproduce and infest your home. Regularly check your cat for any signs of fleas or ticks, and maintain a clean living environment to further reduce risks.

Q10: Is it safe to touch my cat after applying the treatment?

A: After applying either Advantage Multi or Revolution Plus, it’s best to avoid touching the application site until it is dry. This usually takes a few hours. During this time, also prevent children from playing with treated pets and avoid close contact, such as allowing the cat to sleep in the bed.

Q11: What should I do if my cat ingests the treatment?

A: If your cat somehow manages to ingest the treatment, contact your veterinarian immediately. Signs of ingestion can include drooling, vomiting, tremors, or decreased appetite. While the ingredients in Advantage Multi and Revolution Plus are generally safe for felines in the correct dose, ingestion could lead to higher-than-recommended exposure.

Q12: How should I store Advantage Multi or Revolution Plus?

A: Both treatments should be stored at room temperature and kept away from heat or open flame. Make sure they are stored in a place that’s inaccessible to children and pets. Do not refrigerate or freeze the treatments.

Q13: Do I need a prescription for Advantage Multi or Revolution Plus?

A: Yes, both Advantage Multi and Revolution Plus require a prescription from a licensed veterinarian. This ensures your cat is receiving the correct treatment for their specific needs and health status.

Q14: Can Advantage Multi or Revolution Plus be used for long-term flea and parasite prevention?

A: Both Advantage Multi and Revolution Plus are designed for long-term use to provide ongoing protection against fleas and other parasites. Regular monthly applications are recommended for year-round protection, regardless of the season or climate.

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to Top