Adequan Made My Dog Worse

Adequan Canine (polysulfated glycosaminoglycan), a potent joint health supplement, is frequently employed to alleviate the symptoms of osteoarthritis in dogs. While it has shown positive outcomes in many cases, reports of dogs experiencing an apparent worsening of symptoms have raised concerns among pet owners. This article aims to critically examine these incidents and shed light on the intricate relationship between Adequan and canine arthritis.

Understanding the Role of Adequan in Canine Arthritis

Adequan Canine works by inhibiting enzymes that break down cartilage within your dog’s joints. It also stimulates new cartilage production and enhances the synovial fluid’s lubrication properties, which aids in reducing pain and improving mobility.

Can Adequan Make Canine Arthritis Worse?

While the vast majority of dogs respond well to Adequan, there have been isolated reports of pet owners feeling that their dogs’ symptoms worsened after starting this medication. It’s crucial to remember that every dog reacts differently to medication, and what works well for one might not work as effectively for another. In some cases, the perceived worsening could be due to the natural progression of the disease rather than the effect of Adequan.

Factors That Might Mislead Owners

1. The Initial Adjustment Period

Upon initiating treatment, some dogs might exhibit signs of discomfort or appear to have increased difficulty moving. This might be the result of the body adjusting to the new medication rather than the drug itself exacerbating the condition.

2. Progression of Osteoarthritis

Osteoarthritis is a progressive condition, which means that even with treatment, the disease can continue to advance. If a pet owner begins administering Adequan at a later stage of the disease, they might mistake the natural progression of the disease for a worsening of symptoms caused by the drug.

3. Inaccurate Expectations

Adequan is not a miracle cure for arthritis. It’s intended to slow the disease’s progression and alleviate symptoms, but it may not completely eliminate pain or restore mobility. Unrealistic expectations might lead some pet owners to perceive the drug as ineffective or harmful.

When to Consult Your Veterinarian

If you’re giving your dog Adequan and notice a significant decline in their mobility or an increase in their pain, it’s crucial to consult your veterinarian immediately. It may be necessary to reassess the treatment plan or adjust the dosage. In some cases, complementary treatments, such as physical therapy or other medications, might be recommended.


While Adequan Canine has helped many dogs lead more comfortable lives, it’s essential to remember that each dog is unique, and responses to medication can vary. Regular veterinary check-ups are vital to monitor your dog’s progress and make necessary adjustments to their treatment plan. In the end, the goal is to ensure the best quality of life for our furry companions, and that sometimes means adapting and experimenting until we find the right balance of treatments.


Q1: How long does it take for Adequan to start working in dogs?

A1: Adequan starts working within hours of administration, but noticeable improvements in mobility and pain levels may take a few weeks. This is because the drug needs time to help repair existing cartilage damage and stimulate new cartilage growth. Consistent treatment as prescribed by your vet is essential for achieving the best results.

Q2: Can my dog have an allergic reaction to Adequan?

A2: Yes, though allergic reactions to Adequan are rare, they can occur. Symptoms may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Q3: Are there any contraindications for using Adequan in dogs?

A3: Yes, Adequan should not be used in dogs with known or suspected bleeding disorders. It should also be used cautiously in dogs with kidney or liver impairment, as these organs are involved in the drug’s metabolism and excretion. Always disclose your dog’s full medical history to your vet before starting any new medication.

Q4: Can Adequan be used alongside other arthritis treatments?

A4: Yes, Adequan can be part of a multi-modal approach to arthritis treatment. This might include nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, weight management, and other pain-relieving treatments. Your vet can guide you in creating an effective treatment plan tailored to your dog’s specific needs.

Q5: How is Adequan administered to dogs?

A5: Adequan is typically given as an intramuscular injection. The usual protocol involves an initial loading phase, with injections given twice a week for four weeks. After this, the frequency of injections may be reduced, depending on your dog’s response to the treatment. Your vet can demonstrate how to administer these injections at home, or they can be given at the veterinary clinic.

Q6: Can my dog overdose on Adequan?

A6: While rare, an overdose of Adequan can occur if the dog receives more than the prescribed dosage. Symptoms of an overdose can include depression, loss of appetite, and ataxia (lack of muscle control). If you suspect your dog has received an overdose, seek immediate veterinary attention.

Q7: Will my dog need to continue Adequan indefinitely?

A7: The duration of Adequan treatment will depend on the severity of your dog’s arthritis and their response to the medication. In some cases, long-term or even lifelong treatment may be beneficial. Your vet will monitor your dog’s progress and adjust the treatment plan as necessary.

Q8: Is it possible for my dog to develop resistance to Adequan over time?

A8: Unlike some medications, dogs are unlikely to develop resistance to Adequan. This is because the drug works by aiding the body’s natural cartilage repair mechanisms rather than acting on specific receptors that can become less responsive over time.

Q9: What should I do if I miss an Adequan injection for my dog?

A9: If you miss a dose, it’s generally advised to administer the missed dose as soon as you remember, unless it’s close to the time for the next scheduled dose. In this case, skip the missed dose and continue with the regular dosing schedule. However, it’s always best to consult your veterinarian for personalized advice.

Q10: Are there any specific breeds of dogs that respond better to Adequan?

A10: Adequan’s effectiveness doesn’t depend on the breed. It should, theoretically, work equally well for all dogs suffering from osteoarthritis. However, individual responses can vary, and some dogs may seem to respond better than others due to factors like the stage of the disease, overall health, and concurrent treatments.

Q11: Can puppies be given Adequan?

A11: While Adequan is typically used for managing osteoarthritis, which is more common in older dogs, it has been used in puppies, especially those predisposed to joint disorders. However, always consult your vet before starting any new medication in your pet.

Q12: Are there any known drug interactions with Adequan?

A12: While no specific drug interactions have been reported, it’s crucial to inform your vet about all medications, supplements, and over-the-counter drugs your pet is taking. This will allow your vet to assess potential interactions and decide on the best treatment plan for your pet.

Q13: Can Adequan cause behavioral changes in my dog?

A13: While it’s rare, some dogs may exhibit behavioral changes due to the reduction in pain and improved mobility. Increased activity levels can sometimes be mistaken for restlessness or hyperactivity. If you observe any unusual behavioral changes in your pet, it’s advisable to consult with your vet.

Q14: Are there any long-term side effects of Adequan use in dogs?

A14: Long-term side effects of Adequan are rare, but regular veterinary check-ups can help monitor your pet’s health and adjust the treatment plan as necessary. Adequan has been reported to be safe for long-term use in dogs, but if you notice any unusual symptoms, seek veterinary advice immediately.

Q15: Is there a generic version of Adequan available for dogs?

A15: There is no generic equivalent of Adequan available. The active ingredient in Adequan, Polysulfated Glycosaminoglycan (PSGAG), is a complex molecule that is difficult to replicate. Always consult with your vet for the most accurate and up-to-date information regarding available medications.

Q16: Can Adequan be used to treat conditions other than arthritis in dogs?

A16: While Adequan is primarily used to manage signs of non-infectious degenerative or traumatic arthritis, it might be prescribed off-label for other joint-related issues due to its cartilage-repairing properties. However, such use should only occur under the guidance of a veterinarian.

Q17: How should I store Adequan?

A17: Adequan should be stored at controlled room temperature between 20°-25°C (68°-77°F). Always check the manufacturer’s instructions on the packaging for specific storage details. Avoid freezing the product or exposing it to direct sunlight or high temperatures.

Q18: Is it normal for my dog’s condition to worsen after starting Adequan?

A18: It is unusual for a dog’s condition to worsen specifically due to Adequan. The drug is designed to help improve joint health and mobility. However, if you notice a decline in your dog’s condition after starting the medication, contact your vet immediately. The worsening may be coincidental and related to the progression of arthritis, or it could indicate an adverse reaction to the medication.

Q19: Can Adequan cause weight gain in dogs?

A19: Adequan itself does not cause weight gain. However, as the medication can improve mobility and decrease pain, some dogs may become more active and have an increased appetite. Maintaining a balanced diet and regular exercise is key to preventing weight gain in dogs.

Q20: How will I know if Adequan is effective for my dog?

A20: The effectiveness of Adequan can be evaluated through regular veterinary assessments and owner observations. You might notice improvements in your dog’s mobility, such as easier climbing of stairs, less stiffness, or increased willingness to play. Pain levels may also decrease, leading to an overall improvement in your pet’s quality of life.

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to Top