Comfortis vs NexGard vs Credelio Compared
When it comes to protecting your dog from fleas and ticks, the market is flooded with options. Three top contenders—Comfortis, NexGard, and Credelio—stand out for their effectiveness, but how do they compare in key areas? We’ve dug deep into the specifics, and here’s what you need to know.
Key Takeaways: Quick Insights 📝
- Comfortis: Fast-acting flea prevention with a monthly tablet form. Best for flea-only prevention.
- NexGard: Offers flea and tick protection in one convenient chewable, suitable for monthly administration.
- Credelio: A newer option that provides flea and tick control with a smaller chewable size, making it a great pick for dogs with smaller mouths or pickier eaters.
Now, let’s break down each of these options and answer some of the most critical questions pet owners like you have.
Which One Works Fastest? 🏎️
Comfortis: The fastest acting of the three, Comfortis starts killing fleas in just 30 minutes and eliminates 100% of adult fleas within 4 hours. This is ideal if your dog already has a flea infestation and you need immediate results.
NexGard: NexGard is slightly slower than Comfortis, beginning to kill fleas within 4 hours and providing full control in 8-12 hours. Its added tick protection may make it a preferred choice for outdoor pets.
Credelio: Similar to NexGard, Credelio starts to work within 4 hours on fleas, but its full effect on ticks takes about 24-48 hours. Credelio’s steady control ensures ongoing protection over the month.
💡 Tip: If speed is your top priority for immediate flea relief, Comfortis is the clear winner.
Which Option Covers Both Fleas and Ticks? 🦟🕷️
Comfortis: Focused solely on fleas, Comfortis offers no protection against ticks. It’s a great choice if fleas are your primary concern, but you’ll need an additional tick preventative if your dog is exposed to ticks.
NexGard: As a dual flea and tick preventative, NexGard shines in this area. It tackles both parasites effectively, offering monthly protection in a beef-flavored chewable.
Credelio: Like NexGard, Credelio targets both fleas and ticks, but it has a smaller chewable form, making it easier for dogs with smaller mouths to ingest.
💡 Tip: For comprehensive flea and tick protection, NexGard or Credelio are your go-to options.
Which Has the Fewest Side Effects? 🌱
Comfortis: Some dogs experience vomiting after taking Comfortis, particularly if given on an empty stomach. It’s generally considered safe but not ideal for dogs with sensitive stomachs.
NexGard: Side effects are rare but can include diarrhea, lethargy, and vomiting. There have been isolated cases where dogs with a history of seizures had increased seizure activity, so use caution if your dog has this condition.
Credelio: Credelio is relatively gentle on the system, but it can still cause gastrointestinal issues in some dogs. It’s typically well-tolerated by dogs that have shown sensitivity to other oral treatments.
💡 Tip: If your dog is prone to stomach issues, consider Credelio for its gentler profile.
How Easy Is It to Administer? 🐶💊
Comfortis: Comfortis is a tablet that can be tricky for picky eaters. You’ll need to hide it in food or a treat to ensure your dog takes it.
NexGard: A beef-flavored chewable that’s designed to be appetizing. Most dogs will willingly eat it like a treat, making it a convenient option.
Credelio: Smaller than NexGard and easy to give even to small dogs. Its flavoring isn’t quite as enticing as NexGard, but its size makes it easy to hide in food if necessary.
💡 Tip: For dogs that hate pills, NexGard is the most palatable, while Credelio is easier to sneak into food.
How Much Does Each Cost? 💸
| Product | Average Price (per dose) | Protection Offered |
|---|---|---|
| Comfortis | $20-$25 | Fleas only |
| NexGard | $23-$30 | Fleas and ticks |
| Credelio | $18-$25 | Fleas and ticks |
💡 Tip: Credelio tends to be the most cost-effective for flea and tick protection, while Comfortis is more budget-friendly if you don’t need tick prevention.
Which Should You Choose? 🏆
It really depends on your specific needs:
- If fast flea control is critical, go for Comfortis.
- If you need comprehensive flea and tick prevention, NexGard or Credelio are your best bets.
- For a smaller, more budget-friendly chewable, choose Credelio.
Final Comparison Table 🏁
| Feature | Comfortis | NexGard | Credelio |
|---|---|---|---|
| Speed of Action | ⭐⭐⭐⭐⭐ (30 minutes) | ⭐⭐⭐⭐ (4 hours) | ⭐⭐⭐⭐ (4 hours) |
| Covers Ticks? | ❌ No | ✅ Yes | ✅ Yes |
| Side Effects | ⭐⭐⭐⭐ (Mild GI issues) | ⭐⭐⭐ (Watch for seizures) | ⭐⭐⭐⭐ (Gentle) |
| Ease of Admin | ⭐⭐⭐ (Tablet) | ⭐⭐⭐⭐⭐ (Chewable) | ⭐⭐⭐⭐ (Small Chewable) |
| Cost | 💲💲💲 (Affordable) | 💲💲💲💲 (Moderate) | 💲💲💲 (Budget-friendly) |
With this detailed comparison, you’re now armed with the insights to pick the right flea and tick solution for your furry friend. Whether you need fast flea relief, broad parasite protection, or a gentle treatment, one of these options is sure to meet your needs.
Comment Section
Q: Which product is the safest for dogs with sensitive stomachs?
Comfortis can cause gastrointestinal upset in sensitive dogs, particularly if given without food. If your dog has a history of vomiting or stomach issues, Credelio tends to be gentler on the digestive system due to its smaller chewable size and formulation. NexGard, while generally safe, might trigger mild side effects like vomiting or diarrhea in some dogs. However, if your dog suffers from seizures or neurological conditions, consult your vet before using NexGard, as there have been reports of seizure activity increasing in susceptible dogs.
For those dogs with sensitive stomachs, Credelio would be the safest choice. Always monitor for any unusual symptoms after administration.
Q: Can Comfortis and NexGard be used together for extra protection?
It’s understandable to want the best protection for your dog, but Comfortis and NexGard should not be used together unless directed by a veterinarian. Both contain different active ingredients (spinosad for Comfortis and afoxolaner for NexGard), which work in unique ways. Combining them could lead to an overdose or unwanted side effects, especially gastrointestinal distress or neurological reactions. If you are looking for both flea and tick protection, it’s best to stick with NexGard or Credelio, both of which offer comprehensive coverage for fleas and ticks.
For added protection, consult your veterinarian about other options, such as topical treatments or collars that may complement these medications without overlapping their active ingredients.
Q: What if my dog hates taking pills? Is there any way to make it easier?
For dogs that aren’t fond of swallowing tablets, Comfortis can be a bit challenging, as it’s a tablet and may require some coaxing. However, if your dog is a picky eater, hiding the pill in a piece of their favorite food like peanut butter or a cheese slice can help mask the taste. For even more resistant dogs, a pill pocket treat might be a lifesaver.
NexGard and Credelio are easier to administer because they’re chewables—though Credelio is smaller and might be easier to disguise in food if your dog still turns up their nose. NexGard is flavored to appeal to dogs and can often be given as a treat, making the process smoother.
To make it even easier, try turning pill time into a fun experience by giving your dog a reward after they take their medication. This way, they associate it with something positive!
Q: My dog spends a lot of time outdoors. Which option provides the best tick protection?
If ticks are a concern due to your dog’s active outdoor lifestyle, Comfortis isn’t ideal as it only covers fleas. NexGard and Credelio both offer excellent tick protection, making them more suitable for dogs frequently exposed to tick-infested areas like wooded areas, parks, or hiking trails.
Between the two, NexGard has been a long-standing favorite for many pet owners and veterinarians alike, offering trusted monthly protection against a variety of tick species. Credelio, while newer, is rising in popularity due to its smaller, easy-to-swallow chew and steady tick control over 30 days.
For active dogs in tick-heavy environments, NexGard or Credelio will provide the essential dual-action protection needed.
Q: How do I know which product my vet will recommend?
Your veterinarian’s recommendation will depend on several factors, including your dog’s age, weight, lifestyle, and medical history. If your dog frequently interacts with other pets, especially in areas where fleas are prevalent, they may recommend Comfortis for its fast flea-killing action. However, if your dog spends time outdoors or is at risk of tick exposure, the vet is more likely to suggest NexGard or Credelio for their dual flea and tick protection.
The choice may also depend on your dog’s ability to tolerate different medications. For dogs prone to seizures, your vet may opt for Credelio due to its gentle nature compared to NexGard. Additionally, if your dog struggles with swallowing larger tablets, the vet might lean toward Credelio for its smaller, easier-to-ingest chewable.
Ultimately, the recommendation will be tailored to your dog’s specific needs, so always consult your veterinarian to ensure the safest and most effective treatment plan.
Q: How do these medications hold up during rainy weather or bathing?
Since all three options—Comfortis, NexGard, and Credelio—are oral medications, they are unaffected by water exposure. Unlike topical treatments, which can lose effectiveness after bathing or swimming, these pills maintain their efficacy regardless of your dog’s activities. This makes them a more convenient option for dogs that love to swim or require frequent baths.
No need to worry about reapplying after a rainy day or a swim in the lake—these products will keep working for the full month without any decrease in protection.
Q: Is there a risk of parasites becoming resistant to these medications?
Parasite resistance is a concern with any medication used over long periods, but so far, there has been minimal evidence of fleas or ticks developing resistance to Comfortis, NexGard, or Credelio. However, rotating medications or using an integrated approach (such as combining oral medications with environmental flea control methods) can help reduce the risk of resistance developing.
Using these medications as directed—monthly and consistently—is key to ensuring they remain effective. Speak with your veterinarian if you notice a decline in the medication’s effectiveness over time, as they may suggest switching to a different class of flea and tick preventative.
Q: Can these medications be used in puppies?
Yes, all three products have age and weight guidelines for use in puppies. Comfortis can be used in puppies 14 weeks and older, while NexGard and Credelio can be administered to puppies 8 weeks and older. However, the puppies must meet the minimum weight requirements: NexGard and Credelio for dogs weighing at least 4 pounds, and Comfortis for dogs weighing at least 5 pounds.
Always ensure that you are dosing appropriately according to your puppy’s weight and age, and consult your vet if you’re unsure which product is most suitable for your growing pup.
Q: Can I switch between Comfortis, NexGard, and Credelio? Will it affect my dog negatively?
Switching between Comfortis, NexGard, and Credelio is generally safe, but it should be done with careful consideration and, ideally, under the guidance of your veterinarian. These medications work through different active ingredients—spinosad in Comfortis, afoxolaner in NexGard, and lotilaner in Credelio. Each targets fleas and ticks (except Comfortis, which is flea-specific) through unique mechanisms. As long as there’s no overlap in administration—meaning you don’t give two of these medications within the same period—it’s typically safe to transition between them.
For example, if you’re currently using Comfortis and want to switch to NexGard for its tick protection, it’s best to wait until the 30-day period for Comfortis is complete before administering NexGard. Skipping the overlap ensures no heightened risk of side effects, such as vomiting or lethargy, which could occur from an overdose of flea prevention agents. Similarly, if switching to Credelio, ensure a clear timeframe between treatments to prevent overloading your dog’s system with unnecessary chemicals.
If your dog has shown sensitivity to one product, transitioning to another could be beneficial. For instance, if Comfortis causes gastrointestinal upset, switching to Credelio, known for its gentler profile, could provide the needed protection without triggering stomach issues. Always monitor your dog closely for any side effects during the transition period.
Q: Are these medications safe for pregnant or lactating dogs?
None of these three medications—Comfortis, NexGard, or Credelio—are explicitly approved for use in pregnant or lactating dogs. While some studies show minimal risks, the research isn’t conclusive, and most veterinarians advise against administering these products to dogs that are pregnant or nursing without a detailed risk assessment.
The active ingredients in these medications can pass through the placenta and may be present in milk, potentially affecting unborn puppies or nursing litters. If your dog is pregnant or lactating, it’s critical to explore alternative flea and tick prevention methods, such as shampoos or environmental control, until the puppies are weaned. Your veterinarian may also suggest natural or topical solutions that won’t pose a risk to the puppies.
For long-term flea control once the nursing period is over, transitioning back to Comfortis, NexGard, or Credelio may be a suitable option, depending on your dog’s health and needs. Always discuss these choices with your vet to ensure you’re making the safest decision for your pet and her puppies.
Q: What should I do if my dog accidentally gets an extra dose of one of these medications?
Accidentally giving your dog an extra dose of Comfortis, NexGard, or Credelio is a situation that should be handled with caution. The good news is that these medications have wide safety margins, meaning that most dogs will tolerate an extra dose with only mild or temporary side effects. However, it’s still important to monitor your dog closely for signs of overdose or toxicity.
Common side effects of an accidental extra dose include vomiting, diarrhea, lethargy, or a temporary loss of appetite. In most cases, these symptoms resolve on their own within a day or two. If your dog shows more severe symptoms, such as tremors, excessive drooling, difficulty walking, or unusual behavior, contact your vet immediately, as these could indicate a more serious reaction to the excess medication.
In case of an overdose, providing plenty of fresh water and allowing your dog to rest is essential. The vet may recommend giving your dog bland food (such as boiled chicken and rice) to help settle their stomach if vomiting or diarrhea occurs.
To avoid future dosing errors, consider using a reminder system—whether it’s setting a calendar alert or using a pill organizer—so that each dose is given correctly and on time. If you have multiple pets and are concerned about one dog accidentally getting another’s dose, keeping medications clearly labeled and separate is key.
Q: Can I give my dog Comfortis, NexGard, or Credelio if they are on other medications?
In most cases, Comfortis, NexGard, and Credelio are safe to administer alongside other medications. However, it’s essential to be aware of potential drug interactions, particularly if your dog is on medications for serious conditions like seizures, heart disease, or autoimmune disorders. Each product has a unique active ingredient, and while they’re generally well-tolerated, there are some exceptions.
For example, Comfortis (spinosad) has been shown to interact with ivermectin, a common deworming medication and the active ingredient in heartworm preventatives. When spinosad is combined with high doses of ivermectin, it can lead to neurological symptoms like tremors, lethargy, or even seizures. If your dog is on an ivermectin-based heartworm medication, discuss with your vet whether it’s safe to use Comfortis or whether an alternative product like NexGard or Credelio might be more appropriate.
Both NexGard and Credelio are typically safe with most heartworm preventatives and common medications, but dogs with a history of epilepsy or neurological conditions should be closely monitored when taking NexGard. If your dog is on anticonvulsants or medications to manage epilepsy, there may be an increased risk of seizures, and your vet might recommend Credelio due to its lower likelihood of causing such side effects.
To minimize risks, always provide your veterinarian with a full list of your dog’s current medications, including any supplements or over-the-counter products, before starting a flea and tick preventative. This way, they can identify any possible interactions and tailor a treatment plan that’s both effective and safe.
Q: Can I crush the pills and mix them into food if my dog refuses to take them?
While it may seem like a good solution, crushing flea and tick medications such as Comfortis, NexGard, or Credelio and mixing them with food is not generally recommended. These medications are designed to be chewable or ingested whole so that their active ingredients are properly absorbed into your dog’s system. Crushing the tablet can alter the effectiveness of the medication and make it less efficient at controlling fleas or ticks.
For dogs that are picky or refuse to take the medication, it’s better to try hiding the chewable in something they love, like peanut butter, soft cheese, or a small piece of meat. Alternatively, you can use pill pockets—special treats designed to conceal medication—or even ask your vet about flavored versions of the chewables that your dog might find more appealing.
If your dog still resists, and you’ve exhausted all the tricks, talk to your veterinarian. They may recommend an alternative method of flea and tick control that’s easier to administer, such as a topical treatment or an injection, depending on your dog’s needs.