Cost of Simparica Trio: Why is it so Expensive?

Simparica Trio is a highly sought-after medication in the canine world. Revered for its effectiveness against a broad spectrum of parasites such as fleas, ticks, heartworms, hookworms, and roundworms, it’s a real game-changer in pet care. However, many dog owners find themselves questioning, “Why is Simparica Trio so expensive?”

Why Is Simparica Trio So Expensive?

The Power of a Multifaceted Approach

Simparica Trio’s cost is largely a result of its ‘all-in-one’ formula. It contains three active ingredients – Sarolaner, Moxidectin, and Pyrantel – each targeting different parasites. This consolidated approach is a significant factor contributing to its high price point.

Extensive Research and Development

Developing a medication that effectively fights various parasites involves extensive research, clinical trials, and a lengthy approval process from regulatory bodies such as the FDA. These activities are costly, and pharmaceutical companies recuperate these expenses through the medication’s sales.

Superior Efficacy and Broad Spectrum Coverage

Simparica Trio’s superior efficacy and broad-spectrum coverage are central to its high cost. It not only treats and prevents multiple parasites but also offers month-long protection. Its user-friendly, once-a-month oral administration is an added bonus for dog owners struggling with fussy pets.

Alternative Options to Simparica Trio

Despite its benefits, Simparica Trio may not be a feasible option for all pet owners, especially those with multiple dogs. Here are some alternative, cost-effective solutions.

Nexgard and Heartgard Combo

While Nexgard and Heartgard separately target fleas, ticks, and heartworms, using them together can serve as a comprehensive parasitic solution. Though this requires administering two separate medications, it can be a more budget-friendly choice.

K9 Advantix II and Interceptor Plus

K9 Advantix II effectively combats fleas, ticks, and mosquitoes, while Interceptor Plus tackles heartworms and other intestinal parasites. Pairing these two can be a less expensive alternative to Simparica Trio.


Trifexis is a monthly, beef-flavored chewable tablet that prevents heartworm disease, kills fleas, and treats and controls adult hookworm, roundworm, and whipworm infections. However, it does not cover tick prevention.


While Simparica Trio is an excellent ‘one-size-fits-all’ solution to multiple parasites, its price tag may deter some pet owners. Fortunately, there are less expensive alternatives that, when used in combination, provide comprehensive protection. However, always remember to consult your veterinarian before making any changes to your pet’s parasite control regimen. They will be able to provide the best advice based on your pet’s unique needs, your geographical location, and the prevalence of different parasites in your area.

Frequently Asked Questions

1. How Does Simparica Trio Work?

Simparica Trio works thanks to its three potent active ingredients – Sarolaner, Moxidectin, and Pyrantel. Sarolaner targets external parasites such as fleas and ticks, Moxidectin combats heartworm disease, and Pyrantel handles roundworms and hookworms. When given monthly, it provides continuous protection against these common parasites.

2. Can I Use Simparica Trio for All Dog Breeds?

Simparica Trio is designed for use in dogs and puppies over eight weeks of age, weighing at least 2.8 lbs. It’s generally safe for all breeds, but specific breeds may be more susceptible to adverse reactions. Always consult your vet before starting any new medication.

3. Is Simparica Trio Safe for Pregnant or Lactating Dogs?

The safety of Simparica Trio has not been tested in breeding, pregnant, or lactating dogs. As such, consult your veterinarian if you plan to administer this medication to a dog in any of these categories.

4. What Should I Do If My Dog Misses a Dose?

If you forget to give your dog a dose, administer Simparica Trio immediately and resume the monthly dosing schedule. It’s crucial to maintain consistent monthly administration to ensure effective protection against parasites.

5. What Side Effects Can Simparica Trio Cause?

While side effects are rare, they can occur. Some dogs may experience vomiting, diarrhea, lack of appetite, or lethargy. In isolated cases, more severe reactions such as tremors, seizures, or difficulty walking may occur. If any adverse effects are observed, seek immediate veterinary attention.

6. What Precautions Should I Take When Administering Simparica Trio?

Simparica Trio is for canine use only and should be kept out of reach of children. It shouldn’t be used in dogs less than eight weeks old or weighing less than 2.8 lbs. Dogs with a history of seizures or neurological disorders should only take Simparica Trio under close veterinary supervision.

7. Can Simparica Trio Be Used With Other Medications?

Simparica Trio can typically be administered alongside other medications without any issues. However, it’s essential to discuss your dog’s current medications or supplements with your vet to rule out any potential interactions.

8. Is It Safe to Administer Simparica Trio to Puppies?

Yes, Simparica Trio is approved for puppies that are at least eight weeks old and weigh 2.8 lbs or more. It’s crucial to administer the correct dosage based on your puppy’s weight to ensure its safety and effectiveness.

9. Can Simparica Trio Be Used on Other Animals, Like Cats?

Simparica Trio is specifically formulated for dogs and should not be used on other animals. Each species responds differently to medications, and what is safe for one might be harmful to another. Always consult your vet for the appropriate parasitic prevention and treatment for each pet.

10. Can Simparica Trio Treat Existing Heartworm Infections?

No, Simparica Trio is a preventive medication, not a treatment. It helps prevent heartworm disease in dogs by eliminating the tissue stage of heartworm larvae. For dogs already infected with adult heartworms, a different treatment regimen is required. Always have your dog tested for heartworms before starting a preventive regimen.

11. Can I Buy Simparica Trio Without a Prescription?

Simparica Trio is a prescription medication, meaning it should be administered under the guidance of a veterinarian. It’s important to note that it is illegal and unsafe to attempt to purchase Simparica Trio without a valid prescription.

12. What Should I Do If My Dog Accidentally Ingests More Than The Recommended Dosage?

If your dog accidentally consumes more than the recommended dosage of Simparica Trio, contact your vet immediately. Overdosing can lead to heightened risk of side effects, including vomiting, diarrhea, and neurological effects such as tremors or seizures.

13. How Should I Store Simparica Trio?

Simparica Trio should be stored at room temperature, out of direct sunlight, in a safe place where children and pets can’t access it. It is important to keep the chewables in their original packaging until it’s time for them to be administered.

14. How Long Does It Take for Simparica Trio to Start Working?

Simparica Trio starts killing fleas within 3 hours and ticks within 8 hours after administration. However, it may take a bit longer to eliminate internal parasites, with the prevention of heartworm disease becoming effective after about one month.

15. Is There a Specific Time of Year to Give My Dog Simparica Trio?

Parasites can be a year-round problem, and your dog can be at risk of infestations in any season. Thus, Simparica Trio should be administered all year round for the most effective protection.

16. Can Simparica Trio Treat All Types of Ticks?

Simparica Trio is effective against several common species of ticks, including Lone Star ticks, American dog ticks, black-legged ticks, and brown dog ticks. While it offers broad coverage, it may not be as effective against less common or regional tick species. Consult with your vet to confirm the best protection for your pet based on your location and lifestyle.

17. Why Does My Dog Still Have Fleas After Taking Simparica Trio?

While Simparica Trio is highly effective in killing fleas, it doesn’t prevent new fleas in the environment from jumping onto your dog. Continuous exposure to infested environments may result in a new infestation. Moreover, it’s essential to treat all pets in the household and their environment to effectively control flea populations.

18. What Happens If a Human Accidentally Ingests Simparica Trio?

In case of accidental ingestion by humans, immediately contact a poison control center or doctor for advice. It’s important to store Simparica Trio out of the reach of children to avoid such scenarios.

19. Can I Give Simparica Trio with Food?

Yes, Simparica Trio can be given with or without food. Some dogs may prefer taking it with a meal, while others may happily accept it as a treat. It’s designed to be palatable for dogs, so most will readily consume it.

20. What If My Dog Spits Out the Simparica Trio Chewable?

If your dog spits out the chewable, you can try offering it again, possibly with food. If the dog consistently refuses the chewable, reach out to your vet for advice. They may recommend an alternative method of administration or a different medication.

21. What Makes Simparica Trio More Expensive Than Other Treatments?

The cost of Simparica Trio reflects its broad-spectrum coverage, effectiveness, and convenience. It offers protection against a range of common parasites in a single dose, which can save on the cost and hassle of multiple medications. Additionally, the research, development, and safety testing involved in bringing such a product to market also factor into its price.

22. Is There a Generic Version of Simparica Trio Available?

There was no generic equivalent for Simparica Trio available on the market. Always consult your veterinarian for the most current information regarding parasite prevention options.


Leave a Reply

Your email address will not be published. Required fields are marked *

Back to Top