Frontline vs Seresto

When it comes to our furry friends’ health, ensuring they are protected from external parasites like fleas and ticks is paramount. The decision between products like Frontline Plus and Seresto can be a difficult one, with numerous factors to consider. In this comprehensive guide, we’ll dive deep into both of these popular brands, helping you make an informed decision.

Contents hide

What are Frontline Plus and Seresto?

Frontline Plus and Seresto are both well-regarded brands offering potent treatments to protect your pet from fleas and ticks.

Frontline Plus is a topical solution applied directly to the pet’s skin, usually between the shoulder blades. This product, which uses the active ingredients fipronil and (S)-methoprene, kills adult fleas and ticks along with their larvae and eggs. It offers a month-long protection.

Seresto, on the other hand, is a long-lasting flea and tick collar that offers an impressive eight months of protection. This collar, manufactured by Bayer, releases its active ingredients, imidacloprid and flumethrin, over time, providing continuous protection.

Comparative Analysis: Frontline Plus vs Seresto

Duration of Protection

Seresto offers an advantage in terms of the duration of protection. One Seresto collar offers up to 8 months of protection, which means less frequent need for application compared to Frontline Plus, which offers a month of protection and requires monthly application.


Both Frontline Plus and Seresto have shown high effectiveness in dealing with fleas and ticks. However, there have been some reports of fleas developing resistance to the fipronil in Frontline Plus in some regions. This is not a universal issue, but it is something to consider depending on where you live.


Seresto and Frontline Plus are generally safe for most pets. However, some pets may experience mild side effects. These can include temporary skin irritation or hair loss at the site of Frontline Plus application. Similarly, some pets might experience mild reactions to the Seresto collar, such as itchiness or redness. Always observe your pet closely after introducing any new treatment.


Seresto’s collar is a “set it and forget it” solution, which can be more convenient for pet owners who don’t want to worry about monthly applications. However, some pets may not like wearing a collar, making Frontline Plus a potentially better option.

Can Seresto and Frontline Plus be Combined?

Although there is no known adverse interaction between the two products, it is generally not recommended to use multiple flea and tick treatments concurrently unless advised by a veterinarian. Overuse can potentially lead to overexposure to the active ingredients, which could cause side effects.

Other Alternatives to Consider

While Frontline Plus and Seresto are both effective choices, other options on the market include oral treatments like NexGard and Bravecto. These products are chewable, provide protection from fleas and ticks, and can be a good option for pets that dislike topical treatments or collars.

Final Thoughts

Choosing between Frontline Plus and Seresto largely depends on your pet’s needs, your lifestyle, and potentially where you live. Both products have been proven effective, but individual factors such as your pet’s reaction to treatment, comfort wearing a collar, and regional resistance to certain treatments can sway the decision. Always consult with your vet before starting or changing any treatments to ensure your pet’s safety and health.


Q1: Are There Age Restrictions for Frontline Plus and Seresto?

Frontline Plus is safe to use on puppies and kittens from 8 weeks of age and older, while Seresto collars can be used on puppies older than 7 weeks.

Q2: How Do I Choose Between Frontline Plus and Seresto?

Your choice should depend on your pet’s lifestyle, your convenience, and any specific recommendations from your vet. For instance, if your pet is averse to collars, Frontline Plus could be the better option. However, for long-lasting, low-maintenance protection, Seresto might be the more suitable pick.

Q3: Can Frontline Plus and Seresto Be Used Simultaneously?

While there are no known direct interactions, combining treatments should only be done under the supervision of a veterinarian. Overexposure to the active ingredients might lead to side effects.

Q4: Are There Any Side Effects Associated with Frontline Plus and Seresto?

Some pets may experience temporary skin irritation or hair loss at the application site of Frontline Plus. Similarly, reactions to the Seresto collar may include mild itchiness or redness. If your pet shows severe or prolonged symptoms, contact your veterinarian immediately.

Q5: What Should I Do If My Pet Shows Signs of Resistance to Frontline Plus or Seresto?

Resistance or reduced effectiveness can occur in some regions. If you notice that fleas or ticks persist after treatment, contact your veterinarian. They might recommend switching to another product or combining treatments.

Q6: Are There Natural Alternatives to Frontline Plus and Seresto?

Yes, there are natural alternatives such as essential oils and dietary supplements. However, these may not provide the same level of protection as Frontline Plus or Seresto and should be used in consultation with your vet.

Q7: Can I Use Frontline Plus or Seresto on My Pregnant or Lactating Pet?

Frontline Plus is considered safe to use on pregnant and lactating dogs and cats. As for Seresto, it’s best to consult with your vet before using the collar on a pregnant or nursing pet.

Q8: Are Frontline Plus and Seresto Safe for All Breeds?

Generally, both products are safe for all breeds. However, certain breeds may have specific sensitivities or reactions to treatments. Always consult with your vet, especially if your pet is of a unique or mixed breed.

Q9: Can I Use Frontline Plus or Seresto if My Pet Has a Pre-existing Medical Condition?

In the case of pre-existing medical conditions, always consult with your vet before introducing new treatments. Depending on the condition, certain treatments may be more suitable than others.

Q10: Can I Use Frontline Plus or Seresto for Pets Other Than Dogs and Cats?

Frontline Plus and Seresto are specifically formulated for dogs and cats. Using them on other animals could be harmful and is not recommended. Always use treatments that are specifically designed for the species of your pet.

Q11: What Precautions Should I Take When Using Frontline Plus or Seresto?

Always follow the manufacturer’s instructions when using these products. For Frontline Plus, apply it in a place where your pet cannot lick it off, usually between the shoulder blades. For Seresto, ensure the collar is secure but not overly tight, allowing for two fingers to fit between the collar and your pet’s neck.

Q12: How Long Do I Need to Wait to Bathe My Pet After Applying Frontline Plus?

It is recommended to wait at least 48 hours after application before bathing your pet or letting them swim. This allows the product to fully distribute and absorb into the skin.

Q13: Can Frontline Plus or Seresto Be Used During All Seasons?

Yes, both Frontline Plus and Seresto offer protection regardless of the season. In fact, maintaining year-round protection is crucial as fleas and ticks can survive in various environments and climates.

Q14: Is it Normal for My Pet to Scratch More After Applying Frontline Plus?

Some increase in scratching after application can occur as dying fleas may become more active, causing temporary discomfort. If the scratching is excessive or continues for a prolonged period, consult your vet.

Q15: Is the Seresto Collar Water-Resistant?

Yes, the Seresto collar is water-resistant. However, prolonged, intense exposure to water or frequent shampooing can reduce the duration of the collar’s effectiveness.

Q16: How Often Should I Check the Fit of My Pet’s Seresto Collar?

Check the fit regularly, especially for growing puppies. The collar should be snug, allowing two fingers to fit between the collar and the pet’s neck. If the collar becomes too tight or too loose, adjust it accordingly.

Q17: How Should I Dispose of Used Frontline Plus Applicators or the Seresto Collar?

Dispose of used applicators and collars in your regular household waste following local regulations. Do not incinerate or reuse the applicators or collar.

Q18: Can I Use Frontline Plus or Seresto to Treat a Flea or Tick Infestation in My Home?

While these products can effectively treat and prevent infestations on your pet, they are not designed to treat a home infestation. If fleas or ticks are present in your home, you may need to use additional treatments such as sprays or foggers, or consider hiring a professional exterminator.

Q19: My Pet is on Medication. Can I Still Use Frontline Plus or Seresto?

While generally safe, if your pet is on any medication, it is always a good idea to discuss this with your vet before introducing any new treatment, including Frontline Plus or Seresto.

Q20: Can My Children Play with the Pet after Applying Frontline Plus or Attaching the Seresto Collar?

After applying Frontline Plus, it is recommended to avoid touching the application area until it is dry. With the Seresto collar, children can play with the pet as usual, but it is recommended to wash hands after handling the collar. Always follow product guidelines to ensure the safety of both your pets and family.

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to Top