Can Dogs Take Trazodone and Gabapentin?

Gabapentin and trazodone for dogs are highly recommended for treating canine anxiety. However, there are conflicting opinions as to whether you can give your dog trazodone and gabapentin at the same time.

Trazodone and gabapentin together for dogs

Trazodone and gabapentin for dogs

When you have a dog with anxiety, your vet may prescribe gabapentin and trazodone together.

The combination of gabapentin and trazodone can be very effective in treating a lot of symptoms in dogs with anxiety disorders. However, as with any medication, there are risks involved in combining these drugs together.

Gabapentin and trazodone are two drugs that are used for different conditions. They have different mechanisms of action, and they have their own set of side effects.

Gabapentin is an anticonvulsant that is used to treat epilepsy and certain types of nerve pain. It may also be used for other conditions as determined by your veterinarian. It works by slowing down the activity of neurotransmitters in the brain.

Trazodone is an antidepressant that is often prescribed for dogs with anxiety disorders or depression. Trazodone works by boosting levels of serotonin in the brain. These neurotransmitters are responsible for regulating mood and other emotions such as anxiety, stress and depression.

If your dog takes both medications together, it should be done under careful supervision from your veterinarian who will monitor how your dog responds to treatment.

“I have been using this combination for my dog and she seems to be doing better. She is not hyper when she takes the two medicines together. It’s definitely worth a try if your dog has anxiety issues.”

“I have two dogs and both of them had issues with anxiety. I was looking for something that would help them calm down and relax. I did some research online and found that Gabapentin and Trazodone were commonly prescribed for dogs with anxiety issues. My vet said it’s safe to give these medications together because they don’t interact with each other in any way.”

“I started my dog on the combination of Gabapentin and Trazodone when he was diagnosed with cancer last year. This combo has really helped him out a lot! He is no longer scared to go outside or play with his toys, he sleeps better at night, and he doesn’t have any more seizures since we started this medication.”

“I have a 6-year-old Beagle who is on the verge of being housebroken. I have taken her to obedience training classes and worked with her for 2 months. She has been trained to walk on a leash, sit, down, and come when called. I am beginning to see some improvement in her behavior but she still has a lot of issues with aggression toward other dogs, men, and children. She has been on Gabapentin and Trazodone for about 1 week now. I am hoping that this combination will work better than either one alone because she really needs help with her aggression issues. I will update my review after 1 month of treatment if there are any changes or improvements!”

How much trazodone and gabapentin can I give my dog?

The dose of the combined medication is 9 mg/lb of gabapentin and 2.2 mg/lb of trazodone orally. This can be given once or twice daily, depending on the condition being treated.

The goal when giving a combination drug is to give the lowest dose possible that will still relieve your dog’s symptoms. Consult your vet for the best dosage.

What are the side effects of trazodone and gabapentin for dogs?

The most common side effects of trazodone and gabapentin include:

  • Sleepiness
  • Sedation
  • Vomiting
  • Diarrhea
  • Gagging
  • Hypersalivation
  • Paradoxical excitation
  • Behavioral disinhibition
  • Trouble walking or standing

Conclusion of trazodone and gabapentin together for dogs

There are many benefits to combining gabapentin and trazodone: they can be taken together to treat anxiety, depression, and chronic pain.

Gabapentin and trazodone have their own side effects and adverse reactions, but in general, they are safe to use.

Given the possible risks of combining these drugs, it is best to avoid giving them together unless prescribed by your veterinarian.


Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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