Galliprant vs Metacam

Galliprant (grapiprant) and Metacam (meloxicam) are nonsteroidal anti-inflammatory drugs (NSAIDs), widely used in veterinary medicine to manage inflammation and pain associated with osteoarthritis. However, their mechanisms of action differ, which can influence their side effects and efficacy.

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Understanding Arthritis in Dogs

Arthritis, a common condition among aging dogs, results from the degradation of articular cartilage leading to inflammation, pain, and reduced mobility. Treating canine arthritis necessitates an individualized approach, often including weight management, physiotherapy, and medication such as NSAIDs.

Galliprant: A Closer Look

Galliprant is a newer generation drug that selectively blocks the EP4 receptor, a key player in the pathway of inflammation and pain associated with arthritis. This selective action means that Galliprant directly targets the source of pain, making it highly effective while minimizing the impact on other body systems. This receptor specificity often results in fewer gastrointestinal side effects compared to other NSAIDs.

Metacam: What You Need to Know

Metacam, on the other hand, is a more traditional NSAID. It inhibits the enzyme cyclooxygenase, responsible for producing prostaglandins – compounds that trigger inflammation and pain. While effective, its broader spectrum of action may affect more than just the inflammation and pain pathways, potentially leading to a higher incidence of side effects, particularly gastrointestinal issues.

Galliprant vs Metacam: A Comparative Analysis

Efficacy: Both Galliprant and Metacam have been shown to effectively manage pain and inflammation associated with arthritis. However, some pet parents and vets may prefer Galliprant due to its more targeted action, potentially offering a similar level of relief with reduced risk of side effects. Nonetheless, Metacam has a proven track record and remains a go-to choice for many veterinarians.

Side effects: In terms of safety, both drugs have a well-documented profile. Common side effects include vomiting, diarrhea, and decreased appetite. However, long-term use of any NSAID can potentially lead to issues such as kidney, liver, or gastrointestinal problems. Galliprant’s specific action on the EP4 receptor may make it a safer choice for long-term use or for dogs with existing health conditions.

Cost: One major factor that pet parents often consider is cost. Metacam, being an older medication, is generally less expensive than Galliprant. However, considering the potential for reduced side effects and the possible need for fewer vet visits, Galliprant might justify its higher price for some dog owners.

The Right Choice – Individualized Approach

There’s no ‘one-size-fits-all’ answer in choosing between Galliprant and Metacam. Factors such as your dog’s age, overall health, kidney function, response to medication, and even budget, play a crucial role in the decision-making process. Always consult with your veterinarian before starting any medication regimen.


Q1: Can Galliprant and Metacam be used concurrently?

Combining two NSAIDs like Galliprant and Metacam is typically not recommended due to the increased risk of side effects, particularly gastrointestinal issues such as ulcers. Always adhere to your veterinarian’s instructions and never administer two different NSAIDs simultaneously without their express guidance.

Q2: Are there any dietary considerations while administering these medications?

While neither Galliprant nor Metacam requires specific dietary alterations, administering these drugs with food can help to mitigate potential gastrointestinal discomfort. Should your pet experience adverse gastrointestinal symptoms, consult your vet promptly for guidance.

Q3: Is there an age restriction for the use of Galliprant or Metacam?

Both Galliprant and Metacam are generally prescribed for adult and senior dogs. Puppies, especially those under the age of six months, are typically not recommended for these treatments due to the potential for adverse effects on the developing gastrointestinal system and kidneys.

Q4: How quickly can I expect to see an improvement in my dog’s condition with these medications?

While the response can vary among individual dogs, you should generally observe improvement in your pet’s mobility and pain levels within one to two weeks. If you don’t notice any significant changes after this period, it’s wise to consult with your vet for potential adjustments in treatment strategy.

Q5: What precautions should I take if my dog has pre-existing kidney issues?

NSAIDs, including Galliprant and Metacam, can potentially affect kidney function, particularly in dogs with pre-existing kidney conditions. Regular kidney function tests are critical to monitor potential changes. Always consult your vet about your dog’s health history before starting any new medication.

Q6: What if my dog accidentally ingests a larger dose of Galliprant or Metacam?

Overdosing on NSAIDs can lead to serious health consequences, including gastrointestinal upset, ulcers, and kidney failure. If you suspect an overdose, contact your vet or an emergency animal clinic immediately.

Q7: What should I do if my dog shows adverse reactions to either of these medications?

Signs of adverse reactions can include vomiting, diarrhea, change in appetite, lethargy, or changes in drinking or urination patterns. If your dog exhibits any of these signs, discontinue the medication and reach out to your vet as soon as possible.

Q8: Can I transition my dog from one medication to another?

Transitioning between NSAIDs should be done under strict veterinary supervision to avoid “washout” periods and reduce the risk of potential side effects. Never attempt to transition your pet’s medication without consulting your vet first.

Q9: Can Galliprant and Metacam be used for other conditions besides arthritis?

While primarily used for arthritis, Galliprant and Metacam may also be employed in the management of other conditions associated with pain and inflammation, such as post-surgical pain. However, their use should always be under the supervision of a veterinarian.

Q10: Are there any breed-specific considerations when using Galliprant or Metacam?

While no breed-specific restrictions exist, certain breeds may have a predisposition to conditions that could be exacerbated by NSAIDs. For example, breeds prone to kidney issues or gastrointestinal sensitivity may require special monitoring. Always discuss your dog’s breed health predispositions with your vet.

Q11: Can Galliprant or Metacam interact with other medications?

Yes, NSAIDs like Galliprant and Metacam can interact with other medications, including certain steroids, ACE inhibitors, aspirin, and other NSAIDs. Always inform your vet about any medications, including over-the-counter products and supplements, that your dog is currently taking.

Q12: How should Galliprant and Metacam be stored?

Both medications should be stored at room temperature, away from moisture and direct light. Always keep these medications out of reach of children and pets to prevent accidental ingestion.

Q13: What if I miss giving a dose of Galliprant or Metacam to my dog?

If you miss a dose, give it as soon as you remember. However, if it’s close to the time for the next dose, skip the missed dose and continue with the regular schedule. Never give two doses at once or give extra doses.

Q14: Can Galliprant or Metacam cause changes in my dog’s behavior?

While behavioral changes are not a common side effect, any significant changes in your dog’s behavior, energy levels, or eating and drinking habits should be reported to your vet, as these could be signs of adverse reactions to the medication.

Q15: Can my dog develop a dependency on Galliprant or Metacam?

No, NSAIDs like Galliprant and Metacam do not lead to physical or psychological dependency. However, sudden discontinuation after prolonged use may cause a rebound in pain and inflammation, so any changes to the medication regimen should be discussed with your vet.

Q16: Is there a risk of long-term side effects with Galliprant or Metacam use?

Long-term use of any NSAID, including Galliprant and Metacam, can potentially lead to side effects such as gastrointestinal issues, kidney dysfunction, or liver problems. Regular check-ups and routine blood work can help monitor for these potential side effects.

Q17: Can I give Galliprant or Metacam to my dog if she’s pregnant or nursing?

The safety of Galliprant and Metacam in pregnant, breeding, or lactating dogs hasn’t been established. Therefore, always discuss your pet’s reproductive status with your vet before starting these medications.

Q18: Are there specific signs of improvement I should look for after my dog starts taking Galliprant or Metacam?

Signs of improvement can include increased mobility, lessened stiffness, more willingness to engage in physical activities, and an overall improvement in quality of life. However, each dog responds differently, and improvements might not be immediately noticeable.

Q19: How long will my dog need to take Galliprant or Metacam?

The duration of treatment depends on the nature and severity of your dog’s condition. Chronic conditions like arthritis might necessitate long-term, perhaps even lifelong, medication. Your vet will guide you based on your dog’s specific needs.

Q20: What happens if my dog’s body doesn’t respond to Galliprant or Metacam?

If your dog doesn’t show improvement or experiences adverse reactions, your vet might consider changing the medication, adjusting the dosage, or exploring additional treatment options, such as supplements, physical therapy, or alternative pain management techniques.

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