Is Revolution Safe for Dogs with Seizures?

For pet owners, ensuring the health and well-being of their furry companions is paramount. Flea and tick prevention is crucial to keeping our pets healthy, but there’s growing concern among dog owners about the side effects of certain treatments, particularly in dogs with existing health conditions such as seizures. One of the frequently discussed medications is Revolution. So, is Revolution safe for dogs with seizures?

What is Revolution?

Revolution, with its active ingredient Selamectin, is a topical parasiticide used primarily for heartworm prevention, but also for fleas, ear mites, and certain types of mange and ticks in dogs and cats.

Revolution and Seizures: What does the Research Say?

No Direct Link: To date, there is no established direct link between Revolution (Selamectin) and the onset of seizures in dogs. In fact, Selamectin is considered one of the few flea medications that do not have a direct correlation with seizures.

Post-application observations: While some anecdotal reports exist of dogs having seizures after the application of Revolution, a direct cause-and-effect relationship remains unproven. Many factors could contribute to a seizure episode, including underlying health conditions or other environmental triggers.

Choosing the Right Flea Treatment for a Dog with a Seizure History

Consult with a Veterinarian: Before starting any flea or tick preventive, it’s essential to consult with a veterinarian, particularly if your dog has a history of seizures. Your vet can recommend the safest and most effective treatments based on your dog’s specific needs.

Natural Alternatives: Some pet owners opt for natural alternatives like essential oils, diatomaceous earth, or flea combs. While these methods might be less effective than chemical treatments, they pose little to no risk of seizures.

Observation is Key: Regardless of the preventive chosen, it’s crucial to observe your dog after application. Signs of distress, changes in behavior, or physical symptoms should prompt an immediate vet visit.

Safe Practices for Using Revolution on Dogs

Follow Label Instructions: Always apply Revolution according to the label’s instructions. Ensure you’re using the right dosage based on your dog’s weight.

Apply to a Dry Coat: Make sure your dog’s coat is clean and entirely dry before applying the medication. This ensures effective absorption.

Limit Swimming and Bathing: After applying Revolution, refrain from bathing your dog or allowing them to swim for at least two days to ensure the medication has been fully absorbed.


While the connection between Revolution and seizures remains an area of ongoing research, current evidence suggests that Revolution, when used as directed, is a safe option for most dogs, including those with a history of seizures. As always, pet owners should work closely with their veterinarians to determine the best course of action for their individual pets, bearing in mind that each dog’s health and history are unique.

FAQs: Revolution and Canine Seizures

Q: What is the active ingredient in Revolution, and how does it relate to seizures?

A: The main ingredient in Revolution is Selamectin. It targets the nervous system of parasites, rendering them paralyzed and subsequently leading to their death. The association between Selamectin and seizures in dogs is rare, with limited evidence suggesting a direct link. However, as with any medication, individual animals may react differently.

Q: Why might some dogs have seizures after receiving flea treatments, even if it’s not directly related to the medication?

A: While the exact cause isn’t always clear, factors could include underlying health conditions, genetic predispositions, or reactions to inactive ingredients in the product. Stress or the mere act of medication application can also trigger seizures in extremely sensitive dogs.

Q: How can I monitor my dog post-application to ensure they’re not having an adverse reaction?

A: After applying Revolution, observe your dog for the next 24-48 hours. Look for signs like excessive scratching, lethargy, behavioral changes, or any neurological symptoms. If anything seems out of the ordinary, contact your vet immediately.

Q: Are there breeds more predisposed to having seizures when on medication?

A: Certain breeds, especially herding dogs like Border Collies, Australian Shepherds, and Long-haired Whippets, have a genetic mutation (MDR1) that makes them more susceptible to adverse reactions from various drugs. Always check with your vet, especially if you own a breed known for this mutation.

Q: If my dog has a history of seizures, should I avoid using Revolution?

A: If your dog has a known seizure history, always consult your vet before introducing any new medication. While Selamectin’s link to seizures is minimal, it’s crucial to consider all potential triggers for your dog’s health.

Q: How does Revolution compare to other flea treatments regarding seizure risks?

A: Some flea and tick medications have garnered attention due to potential seizure risks, but Selamectin isn’t widely recognized as one of them. It’s always essential to evaluate each treatment on a case-by-case basis, considering your dog’s specific health history and needs.

Q: Can environmental factors increase the risk of seizures in dogs using Revolution?

A: While there’s no direct evidence linking environmental factors with Revolution-induced seizures, things like extreme temperatures, exposure to toxins, or simultaneous use of other medications could increase seizure risks in general.

Q: If not Revolution, what other preventative treatments might be safer for dogs with seizure disorders?

A: There are various flea and tick preventatives available, both topical and oral. If you’re concerned about Revolution, consult with your veterinarian. They can recommend alternatives based on your dog’s specific health profile and needs.

Q: Can I combine Revolution with other treatments or supplements to reduce the risk of seizures?

A: It’s not advisable to combine medications without your veterinarian’s guidance. While certain supplements or treatments might benefit dogs with seizure disorders, it’s essential to ensure no unintended interactions that could exacerbate the condition.

Q: Are there holistic or natural alternatives to Revolution that are effective?

A: Some pet owners explore natural alternatives like diatomaceous earth, essential oils, or garlic. However, the efficacy of these methods varies, and they may not provide comprehensive protection. Always discuss any natural remedies with your vet to ensure they’re safe and appropriate for your pet.

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