Is Deramaxx Safe for My Dog?

Deramaxx is a medication that’s often prescribed to dogs to manage pain and inflammation. However, like any medication, it can have side effects that may harm your furry friend. Here are some possible reasons why Deramaxx can harm your dog:

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1. Overdose or Incorrect Dosage

One of the most common reasons why Deramaxx can harm your dog is an overdose or incorrect dosage. Giving your dog too much of the medication can lead to severe side effects such as vomiting, diarrhea, lethargy, seizures, and even death. On the other hand, giving your dog too little of the medication may not effectively manage their pain and inflammation.

2. Pre-existing Health Conditions

If your dog has pre-existing health conditions, they may be more susceptible to the harmful effects of Deramaxx. Dogs with liver or kidney disease, heart disease, and gastrointestinal problems are particularly at risk. Be sure to let your vet know if your dog has any underlying health issues before administering Deramaxx.

3. Age and Breed

The age and breed of your dog can also impact how well they tolerate Deramaxx. Older dogs may have a harder time processing the medication, while certain breeds such as Greyhounds and Collies may be more sensitive to its effects. Your vet can help determine if Deramaxx is safe for your dog based on their age and breed.

4. Allergic Reactions

In rare cases, dogs may have an allergic reaction to Deramaxx. Signs of an allergic reaction include hives, swelling, difficulty breathing, and collapse. If you suspect your dog is having an allergic reaction to Deramaxx, seek veterinary care immediately.

5. Interactions with Other Medications

Deramaxx may interact with other medications your dog is taking, including over-the-counter supplements and herbal remedies. Always inform your vet of any medications or supplements your dog is taking to avoid potential interactions.

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Deramaxx is a commonly prescribed NSAID for dogs and is effective in treating pain and inflammation associated with osteoarthritis and other musculoskeletal conditions.

It is available in a chewable tablet form, making it easy to administer to dogs.


Deramaxx has been linked to a number of serious side effects, including kidney and liver failure, gastrointestinal bleeding, and blood disorders.

Long-term use of the medication may increase the risk of these side effects.

Side Effects:

Some common side effects of Deramaxx include vomiting, diarrhea, loss of appetite, and lethargy.

More serious side effects include blood in the urine, yellowing of the skin or eyes, and difficulty breathing.


Deramaxx is considered a relatively safe medication for dogs when used as directed.

However, overdose or long-term use can lead to toxicity and potential organ damage.

Drug Interactions:

Deramaxx can interact with other medications, including blood thinners and steroidal drugs.

It is important to inform your veterinarian of any other medications your dog is taking before starting Deramaxx.


Deramaxx should not be used in dogs with a history of stomach or intestinal ulcers, bleeding disorders, or liver or kidney disease.

It should also not be used in pregnant or lactating dogs.

Research and Study:

A number of studies have been conducted on the safety and efficacy of Deramaxx in dogs.

These studies have shown that while the medication is effective in treating pain and inflammation, it does come with a potential risk of serious side effects.

FAQs about Deramaxx for dogs

To help you make an informed decision about your dog’s medication, here are some frequently asked questions about Deramaxx:

What are the most common side effects of Deramaxx in dogs?

The most commonly reported side effects of Deramaxx in dogs are gastrointestinal (GI) problems, such as vomiting, diarrhea, and loss of appetite. These symptoms may occur within the first few days of treatment and usually resolve on their own, but you should monitor your dog’s condition and inform your veterinarian if they persist or worsen.

Can Deramaxx cause serious or life-threatening side effects?

Yes, Deramaxx can cause serious or life-threatening side effects in some dogs, especially if they have preexisting health issues or are taking other medications that interact with NSAIDs. The most concerning side effects of Deramaxx are liver and kidney damage, bleeding disorders, and anaphylactic shock. These conditions may manifest as lethargy, jaundice, pale gums, black tarry stools, or difficulty breathing. If you notice any of these signs, seek veterinary attention immediately.

How can I minimize the risk of Deramaxx side effects in my dog?

To minimize the risk of Deramaxx side effects in your dog, you should follow the dosage and administration instructions provided by your veterinarian carefully. Do not give Deramaxx to a dog that is allergic to NSAIDs, has a history of GI ulcers or bleeding, or has kidney or liver disease. You should also avoid giving Deramaxx to pregnant or nursing dogs unless advised by your veterinarian. Additionally, you should monitor your dog’s response to the medication and report any unusual symptoms or behaviors to your veterinarian.

Are there any natural or alternative remedies for pain relief in dogs that do not have side effects?

Yes, there are some natural or alternative remedies for pain relief in dogs that do not have significant side effects or risks. These may include acupuncture, massage, physical therapy, herbal supplements, or dietary changes. However, not all of these remedies are supported by scientific evidence or suitable for all dogs. You should consult with a qualified holistic or integrative veterinarian to determine the best course of treatment for your dog’s specific condition and needs.

Should I stop giving Deramaxx to my dog if he or she shows signs of side effects?

If your dog shows signs of mild to moderate side effects of Deramaxx, such as GI upset, you may consider reducing the dosage or frequency of administration, or switching to another NSAID with a different mechanism of action. However, you should not stop giving Deramaxx abruptly or without consulting your veterinarian, as this may cause rebound pain or withdrawal symptoms. If your dog shows signs of severe or life-threatening side effects, you should seek emergency veterinary care and follow your veterinarian’s instructions.

Is it safe to give Deramaxx to senior dogs or dogs with chronic conditions?

Deramaxx can be used in senior dogs or dogs with chronic conditions, but the dosage and frequency may need to be adjusted based on the dog’s individual needs and health status. Senior dogs and dogs with kidney or liver disease may be more susceptible to the side effects of Deramaxx, so they should be monitored carefully and receive regular blood tests to check their organ function. Your veterinarian may recommend alternative pain management strategies or a lower dose of Deramaxx for these dogs.

Can Deramaxx interact with other medications or supplements?

Yes, Deramaxx can interact with other medications or supplements that your dog may be taking, such as corticosteroids, anticoagulants, diuretics, or certain antibiotics. These interactions can increase the risk of side effects or reduce the effectiveness of the medication. Therefore, it is important to inform your veterinarian about all the medications and supplements your dog is taking, and to follow their instructions regarding dosing and timing. Your veterinarian may need to adjust the dose or frequency of Deramaxx or switch to a different medication to avoid interactions.

What should I do if I miss a dose of Deramaxx?

If you miss a dose of Deramaxx, you should give it as soon as you remember, unless it is almost time for the next scheduled dose. In that case, you should skip the missed dose and resume the regular dosing schedule. Do not give a double dose of Deramaxx to make up for a missed dose, as this can increase the risk of side effects. If you have trouble remembering when to give Deramaxx, you may consider setting a reminder or using a pill dispenser.

How long can my dog take Deramaxx safely?

The duration of Deramaxx treatment depends on the reason for use, the severity of the condition, and the individual response of your dog. In general, Deramaxx should be used for the shortest duration necessary to achieve pain relief and inflammation control. Prolonged use of NSAIDs can increase the risk of side effects, especially in senior dogs or dogs with preexisting conditions. Your veterinarian may recommend periodic blood tests to monitor your dog’s organ function and adjust the dosage or frequency of Deramaxx accordingly.

What should I do if my dog has an allergic reaction to Deramaxx?

If your dog has an allergic reaction to Deramaxx, such as hives, facial swelling, or difficulty breathing, you should stop giving the medication immediately and seek emergency veterinary care. Anaphylactic shock is a rare but serious complication of NSAID use, and can be fatal if not treated promptly. Your veterinarian may administer epinephrine, antihistamines, and supportive care to stabilize your dog’s condition. You should also inform your veterinarian of any previous reactions your dog may have had to medications or foods, so they can avoid potential allergens in the future.

Can Deramaxx cause stomach ulcers or bleeding in dogs?

Yes, like all non-steroidal anti-inflammatory drugs (NSAIDs), Deramaxx can cause stomach ulcers or bleeding in dogs, especially if given at high doses or for prolonged periods. This risk is higher in senior dogs, dogs with preexisting gastrointestinal problems, or dogs taking other medications that can affect blood clotting. If your dog develops symptoms of gastrointestinal ulceration or bleeding, such as vomiting blood, black or tarry stools, abdominal pain, or loss of appetite, you should stop giving Deramaxx and contact your veterinarian immediately.

Can Deramaxx be used in pregnant or nursing dogs?

The safety of Deramaxx in pregnant or nursing dogs has not been established, and it is not recommended for use in these populations unless the potential benefits outweigh the risks. Deramaxx can cross the placental barrier and be excreted in milk, which can potentially affect fetal development or nursing puppies. If your dog is pregnant or nursing, you should discuss the risks and benefits of using Deramaxx with your veterinarian, and consider alternative pain management strategies if possible.

Can I give my dog human pain medications instead of Deramaxx?

No, you should never give your dog human pain medications, such as aspirin, ibuprofen, or acetaminophen, as they can be toxic and potentially fatal to dogs. These medications can cause gastrointestinal, liver, or kidney damage, as well as blood disorders or central nervous system depression. Only medications specifically approved for use in dogs, such as Deramaxx, should be given to your dog, and only under the guidance of a licensed veterinarian.

DERAMAXX® (deracoxib) Before and After Videos

Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

One Response

  1. I read this article today on February 26th 2022 because my husband and I lost our beloved cane corso named Maxx due to Carprofen. We are heartbroken and understand the pain many pet owners like many of the people on Bestie Paws have already experienced. The drug companies need more accountability with these drugs which have been proven too many times to be fatal. I really like Bestie Paws and the articles I have read, indeed we love our pets. Thank you and please keep readers and pet owners all over informed about these toxic medications prescribed and produced by these drug companies. Thank you so much for sharing your stories.

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