Side Effects of Trazodone for Dogs
Trazodone is a medication commonly used to treat anxiety and behavioral issues in dogs. It is a serotonin antagonist and reuptake inhibitor, which means it helps to regulate the levels of serotonin in the brain. While it is generally considered safe for use in dogs, it can cause certain side effects. Here is a list of the most common side effects of trazodone in dogs:

1. Drowsiness
One of the most common side effects of trazodone in dogs is drowsiness. This can be a desired effect for dogs with anxiety or behavioral issues, as it can help them to relax and feel calmer. However, if your dog is experiencing excessive drowsiness, it may be a sign that the dosage needs to be adjusted.
2. Loss of appetite
Some dogs may experience a loss of appetite while taking trazodone. This can be due to the medication’s effect on serotonin levels in the brain, which can affect the way the dog perceives food. If your dog is not eating, it is important to talk to your vet about adjusting the dosage or switching to a different medication.
3. Vomiting and diarrhea
Some dogs may experience stomach upset while taking trazodone, resulting in vomiting and diarrhea. This is usually a temporary side effect that can be managed by adjusting the dosage or giving the medication with food.
4. Lethargy
Some dogs may experience a lack of energy or motivation while taking trazodone. This can make it difficult for them to engage in normal activities such as playing or going for walks.
5. Changes in behavior
Trazodone can affect serotonin levels in the brain, which can lead to changes in behavior. Some dogs may become more aggressive or anxious while taking the medication, while others may become more docile or subdued.
6. Dry mouth
Trazodone can cause dry mouth in some dogs, which can lead to increased thirst and difficulty eating or drinking.
7. Constipation
Some dogs may experience constipation while taking trazodone. This can be due to the medication’s effect on the gastrointestinal system and can be managed by adjusting the dosage or giving the medication with food.
8. Hormonal imbalances
Trazodone can affect the production of hormones in the body, which can lead to a variety of side effects. Some dogs may experience changes in weight or appetite, while others may experience changes in their coat or skin.
9. Seizures
Trazodone can increase the risk of seizures in dogs, especially in those with a history of seizures. If your dog experiences a seizure while taking trazodone, it is important to seek immediate medical attention and speak with your vet about discontinuing the medication.
How does trazodone make dogs feel?
One of the main effects of trazodone in dogs is an increase in relaxation and a reduction of anxiety. This can be beneficial for dogs that experience separation anxiety, noise phobias, or other forms of anxiety. Trazodone can also help dogs with behavioral issues such as aggression, as the increased relaxation can reduce the likelihood of aggressive behavior.
In addition to reducing anxiety, trazodone can also help dogs with insomnia. The medication can promote drowsiness and improve sleep patterns, which can be beneficial for dogs that have trouble sleeping or wake up frequently during the night.
While trazodone can be effective in treating anxiety and insomnia in dogs, it should not be used as a long-term solution. It is important to work with a veterinarian to determine the underlying cause of the anxiety or insomnia and address it through behavior modification and other forms of treatment.
How long does it take for trazodone to wear off in dogs?
The duration of trazodone’s effects in dogs can vary depending on several factors such as the dog’s age, weight, and overall health. Additionally, the dosage of the medication and the frequency of administration can also affect the duration of its effects. Generally, trazodone’s effects can last anywhere from 4 to 8 hours in dogs. However, individual variations may occur and some dogs may experience longer or shorter effects.
Trazodone’s effects may be more pronounced in some dogs, while others may not experience as strong of an effect. This is why it is important to monitor your dog’s behavior and response to the medication and adjust the dosage accordingly. In case of any adverse reactions, it is important to consult with your veterinarian immediately.
What happens if I give my dog too much trazodone?
Giving your dog too much trazodone can have serious consequences:
Sedation and drowsiness: This can lead to a decreased level of activity and a lack of coordination. In severe cases, it can even cause a loss of consciousness.
Respiratory depression: This means that the dog’s breathing rate may slow down, and they may have difficulty breathing. This can be life-threatening and requires immediate medical attention.
Increase in blood pressure: This can lead to problems with the heart, such as an irregular heartbeat or a heart attack.
Gastrointestinal problems, such as nausea, vomiting, and diarrhea: These symptoms can be uncomfortable for your dog and can lead to further health complications if left untreated.
Is there an alternative to trazodone for dogs?
If you are concerned about the use of trazodone for your dog, there are safer alternatives that you can consider.
Behavioral modification therapy: This type of therapy is designed to help dogs learn new behaviors and manage their anxiety. It involves working with a certified trainer or behaviorist who can help you identify the triggers that cause your dog’s anxiety and teach them coping mechanisms.
Pheromone therapy: Pheromones are natural chemicals that can be used to help dogs feel calm and relaxed. There are several pheromone products available, such as sprays, diffusers, and collars, that can be used to help reduce your dog’s anxiety.
Nutritional supplements: Certain supplements, such as omega-3 fatty acids, can help reduce inflammation and promote overall well-being in dogs. They can also be used to help manage anxiety and depression.
Exercise and playtime: Regular exercise and playtime can help dogs release pent-up energy and reduce anxiety. Engaging in activities such as fetch, agility training, and walks can help dogs feel calmer and more relaxed.
Acupuncture: Acupuncture is a holistic therapy that involves the insertion of thin needles into specific points on the body. It can be used to help dogs with anxiety and depression by promoting relaxation and reducing inflammation.
Trazodone for dogs reviews
Pros:
Trazodone has been found to be effective in treating anxiety, aggression, and separation anxiety in dogs.
It can also be used as a sleep aid for dogs with insomnia.
Trazodone has a relatively low risk of side effects compared to other antidepressants.
Cons:
Trazodone can cause sedation and dizziness in some dogs, which may affect their mobility and ability to perform daily tasks.
It can also cause dry mouth and decreased appetite in some dogs.
Trazodone may interact with other medications, so it is important to inform your vet of any other drugs your dog is taking before starting treatment.
Side effects:
Common side effects of trazodone in dogs include sedation, dizziness, dry mouth, and decreased appetite.
Less common side effects include vomiting, diarrhea, and increased thirst.
In rare cases, trazodone can cause more severe side effects such as seizures or allergic reactions.
Toxicity:
Trazodone is relatively safe for dogs when used at the recommended dosage.
Overdose can cause severe sedation, low blood pressure, and other serious side effects.
If your dog ingests a large amount of trazodone, contact your vet immediately.
Drug interactions:
Trazodone may interact with other medications, particularly other antidepressants, sedatives, and anti-anxiety drugs.
It is important to inform your vet of any other drugs your dog is taking before starting treatment with trazodone.
Contraindications:
Trazodone should not be used in dogs with a history of seizures or other CNS disorders
Pregnant and lactating dogs should not take Trazodone
Research and Study:
Trazodone has been studied in several clinical trials for its effectiveness in treating anxiety and aggression in dogs.
Studies have found that trazodone is effective in reducing anxiety symptoms and improving the quality of life for dogs with behavioral issues.
Alternatives:
Other antidepressants, such as fluoxetine and clomipramine, may be used to treat anxiety and aggression in dogs.
Behavioral therapy and training may also be effective in treating these issues in dogs.
Some natural remedies such as CBD oil and pheromone therapy can be considered as alternatives.
FAQs about side effects of Trazodone in dogs
Here are some frequently asked questions about the side effects of Trazodone in dogs, along with some helpful answers.
What are some common side effects of Trazodone in dogs?
Trazodone is generally considered to be safe for dogs when used as directed, but there are some potential side effects that you should be aware of. Some of the most common side effects include:
- Drowsiness or lethargy
- Nausea or vomiting
- Diarrhea
- Increased agitation or anxiety (in rare cases)
What should I do if my dog experiences side effects from Trazodone?
If your dog experiences any side effects from Trazodone, it’s important to contact your veterinarian right away. Depending on the severity of the side effects, your vet may recommend adjusting the dosage or switching to a different medication altogether.
How can I minimize the risk of side effects when giving my dog Trazodone?
To help minimize the risk of side effects when giving your dog Trazodone, it’s important to follow your veterinarian’s instructions carefully. Be sure to give the medication at the same time every day and follow any dietary restrictions or other guidelines that your vet recommends. Additionally, be sure to monitor your dog closely for any signs of side effects, especially when first starting the medication.
Are there any long-term side effects of Trazodone in dogs?
There isn’t a lot of research on the long-term effects of Trazodone in dogs, but in general, it’s considered to be safe for long-term use when prescribed and monitored by a veterinarian. However, as with any medication, there is always a risk of long-term side effects, so it’s important to keep an eye on your dog’s overall health and well-being while they’re taking Trazodone.
Can Trazodone interact with other medications my dog is taking?
Yes, Trazodone can interact with other medications that your dog may be taking. Be sure to inform your veterinarian of any other medications, supplements, or herbal remedies that your dog is taking before starting them on Trazodone. Your vet can help determine whether any potential drug interactions exist and adjust the dosage or timing of medications as needed.
What should I do if I accidentally give my dog too much Trazodone?
If you accidentally give your dog too much Trazodone, it’s important to contact your veterinarian right away. Depending on the severity of the overdose, your vet may recommend inducing vomiting or providing other supportive care to help your dog recover.
Can Trazodone cause any serious side effects in dogs?
In rare cases, Trazodone can cause more serious side effects in dogs, such as seizures, respiratory depression, or low blood pressure. If you notice any of these symptoms in your dog, it’s important to contact your veterinarian right away.
Can Trazodone cause aggression in dogs?
While Trazodone is typically used to help calm dogs with anxiety or aggression issues, in rare cases, it can actually cause increased agitation or aggression. If you notice any unusual or concerning changes in your dog’s behavior while they’re taking Trazodone, be sure to contact your veterinarian right away.
How quickly do the side effects of Trazodone typically appear?
The side effects of Trazodone can vary depending on the individual dog and the dosage of medication they’re taking. In general, however, you may start to notice side effects within a few hours of giving your dog the medication. If side effects persist or worsen over time, it’s important to contact your vet for guidance.
Is Trazodone safe for all dogs to take?
Trazodone is generally considered safe for most dogs when prescribed and monitored by a veterinarian. However, like any medication, there may be some dogs who are more sensitive to the drug or who may be at a higher risk for side effects. Be sure to discuss your dog’s individual health history with your vet to determine if Trazodone is the right choice for them.
Are there any breeds of dogs that are more prone to side effects from Trazodone?
There isn’t any research to suggest that certain breeds of dogs are more prone to side effects from Trazodone than others. However, as with any medication, it’s important to monitor your dog closely for any signs of side effects, regardless of their breed.
Can Trazodone be used alongside other anxiety medications for dogs?
Yes, in some cases, Trazodone can be used alongside other anxiety medications for dogs. Your veterinarian can help determine if this is a safe and effective treatment option for your dog based on their individual health history and medication regimen.
Can Trazodone cause any long-term health problems in dogs?
There isn’t any evidence to suggest that Trazodone can cause long-term health problems in dogs when used as directed. However, as with any medication, there is always a risk of side effects, and it’s important to monitor your dog closely for any signs of adverse reactions or changes in health over time.
What should I do if my dog has an allergic reaction to Trazodone?
If your dog has an allergic reaction to Trazodone, it’s important to seek veterinary care immediately. Signs of an allergic reaction may include swelling, hives, difficulty breathing, or other symptoms. Your veterinarian can provide emergency treatment to help alleviate your dog’s symptoms and prevent any serious complications.
How long does it take for Trazodone to start working on dogs?
The time it takes for Trazodone to start working in dogs can vary depending on the individual dog and the condition being treated. In general, you may start to see some improvement in your dog’s anxiety or behavior within a few hours of giving them Trazodone. However, it’s important to follow your veterinarian’s dosage instructions carefully and allow enough time for the medication to take effect.
What should I do if I miss a dose of Trazodone for my dog?
If you accidentally miss a dose of Trazodone for your dog, it’s generally safe to give them the missed dose as soon as you remember. However, if it’s close to the time for their next scheduled dose, it’s best to skip the missed dose and resume their regular dosing schedule. Never double up on a missed dose of Trazodone, as this can increase the risk of side effects.
Can Trazodone cause digestive upset in dogs?
Yes, some dogs may experience digestive upset as a side effect of Trazodone. This can include symptoms such as vomiting, diarrhea, or loss of appetite. If your dog experiences any digestive issues while taking Trazodone, be sure to let your veterinarian know so they can provide guidance on managing these symptoms.
How should I store Trazodone for my dog?
Trazodone should be stored in a cool, dry place away from light and moisture. It’s important to keep the medication out of reach of children and pets, as it can be harmful if ingested. Be sure to follow the storage instructions provided by your veterinarian or on the medication label.
Are there any interactions between Trazodone and other medications my dog is taking?
Trazodone can interact with certain medications, so it’s important to let your veterinarian know about any other medications your dog is taking before starting them on Trazodone. This includes both prescription and over-the-counter medications, as well as supplements or herbal remedies. Your veterinarian can help determine if Trazodone is safe to use alongside any other medications your dog is taking.