🐾 My Dog Has Never Been the Same Since Taking Apoquel: What You Need to Know to Solve the Issue

When your dog is prescribed Apoquel to manage allergic skin reactions like itching or dermatitis, it can feel like a lifesaver. However, for some pet owners, the results may not always be as expected. Dogs can sometimes experience unexpected side effects that leave their owners questioning whether the treatment was worth it.

Key Takeaways: Quick Answers to Common Concerns About Apoquel 🐕

What is Apoquel? Apoquel is a medication designed to treat itching and inflammation caused by allergies in dogs.
Why is my dog acting differently on Apoquel? Some dogs experience side effects like lethargy, behavioral changes, or digestive issues.
Can I stop Apoquel suddenly? Always consult your vet before discontinuing any medication. Stopping abruptly can lead to a flare-up of allergic symptoms.
Are there alternatives to Apoquel? Yes, options include Cytopoint, allergy testing, or natural remedies.
Is long-term use of Apoquel safe? Long-term use has been associated with immune suppression and an increased risk of infections. It’s crucial to monitor your dog closely.

🐾 What Is Apoquel and How Does It Work?

Apoquel is an oral medication that specifically targets and reduces the production of cytokines—proteins responsible for inflammation and itching in dogs with allergies. It’s often prescribed for dogs with atopic dermatitis, environmental allergies, or food sensitivities.

Fast-acting relief: Apoquel typically works within 4 hours and can significantly reduce itching in 24 hours.
Short-term use: It’s especially effective for short-term relief of severe itching but can also be prescribed for long-term management of chronic allergies.

💡 Pro Tip: If your dog is experiencing immediate relief from itching but shows other behavioral changes, this could be a sign of an underlying issue caused by the medication. Always keep an eye on mood shifts or physical symptoms after starting Apoquel.

🧐 Why Has My Dog Changed Since Starting Apoquel?

Some pet owners report that their dog’s personality or behavior changes after starting Apoquel. While Apoquel is designed to relieve itching, it can sometimes cause side effects that may make your dog seem like they’re “not the same.”

Common Side Effects

Side Effect	Description	🐕 What You Can Do
Lethargy	Dogs may seem more tired or less playful than usual.	Allow your dog to rest and monitor their energy levels over time.
Diarrhea or Vomiting	Gastrointestinal issues may occur as their body adjusts.	Offer a bland diet like boiled chicken and rice to ease digestion.
Increased thirst/urination	Apoquel can sometimes cause excess thirst, leading to frequent urination.	Ensure your dog has access to fresh water and monitor their bathroom habits.
Behavioral changes	Some dogs may become more anxious or restless.	Keep a behavior log and discuss these changes with your vet.

💡 Pro Tip: If your dog is showing unusual behavior, keep track of when it started and how often it occurs. This will help your vet assess whether Apoquel is the cause and whether a dosage adjustment or alternative medication is necessary.

🚨 Can Apoquel Cause Long-Term Health Problems?

Long-term use of Apoquel may have immune-suppressing effects, which can make your dog more vulnerable to infections or tumors. This is because Apoquel inhibits not only the inflammatory response but also certain aspects of the immune system.

Immune suppression: Dogs on long-term Apoquel may experience a higher risk of skin infections, urinary tract infections, or other infections due to the suppression of their immune response.
Tumor growth concerns: Some studies suggest a slightly increased risk of developing tumors in dogs taking Apoquel for extended periods. While not common, it’s a concern that warrants discussion with your vet.

💡 Pro Tip: Schedule regular vet check-ups to monitor your dog’s overall health and to catch any potential issues early. Blood work and regular physical exams can help ensure that your dog remains healthy while on Apoquel.

🌿 Are There Safer Alternatives to Apoquel?

If you’re uncomfortable with the side effects or risks associated with Apoquel, there are alternative treatments that can manage your dog’s allergies without the same immune suppression risks.

Alternatives to Apoquel

Alternative	How It Works	🐶 Best For
Cytopoint	A biologic injection that targets itch-causing cytokines without suppressing the immune system.	Dogs needing long-term allergy control without immune suppression.
Allergy Testing & Immunotherapy	Identifies specific allergens and develops a custom treatment plan to desensitize your dog.	Dogs with chronic allergies or those unresponsive to medications.
Natural Remedies	Omega-3 supplements, quercetin, or coconut oil to reduce inflammation naturally.	Dogs with mild symptoms or those sensitive to medications.

💡 Pro Tip: If you’re interested in natural options, start by incorporating fish oil into your dog’s diet. Omega-3 fatty acids have strong anti-inflammatory properties that can help reduce allergy symptoms.

🐾 How Can I Safely Wean My Dog Off Apoquel?

If you’ve decided that Apoquel is not the best option for your dog, it’s important to wean them off the medication safely to avoid a rebound effect, where their symptoms return even worse than before.

Consult your vet: Always talk to your vet before making any changes to your dog’s medication. They can create a tapering schedule to gradually reduce the dosage.
Combine with alternatives: If you’re transitioning away from Apoquel, consider starting an alternative treatment, such as Cytopoint or natural supplements, to manage symptoms during the weaning process.
Monitor closely: As you taper off Apoquel, keep a close eye on any signs of increased itching, skin irritation, or infections. If symptoms worsen, it may be necessary to reconsider Apoquel or explore other options.

💡 Pro Tip: Introduce a hypoallergenic diet or increase the use of anti-itch supplements like quercetin during the weaning process to help your dog’s body adjust without experiencing a flare-up in symptoms.

🗝️ Key Takeaways on Apoquel and Your Dog’s Health

Monitor for changes: If your dog’s behavior or health has changed since starting Apoquel, document the symptoms and report them to your vet.
Explore alternatives: Consider other treatment options like Cytopoint or allergy testing if Apoquel is causing concerning side effects.
Wean safely: Never stop Apoquel abruptly—work with your vet to create a tapering plan.
Long-term use caution: While effective for allergy relief, long-term Apoquel use may increase the risk of infections and immune-related issues.
Consider natural remedies: For dogs with mild allergies, explore natural anti-inflammatory supplements like Omega-3s or quercetin.

If Apoquel has changed your dog in ways you didn’t expect, don’t worry—you have options. By exploring alternatives, working closely with your vet, and monitoring your dog’s health, you can find the right balance to restore their quality of life. 🐾❤️

Comment 1: “Since starting Apoquel, my dog has been lethargic and not as playful. Is this normal? Should I be concerned?”

It’s understandable that you’re concerned, especially if your dog’s energy levels have noticeably decreased. While Apoquel is generally well-tolerated, lethargy can occur as a side effect in some dogs, particularly during the initial adjustment period. Here’s what could be happening:

Body adjusting to the medication: Apoquel works by suppressing certain inflammatory pathways to reduce itching and discomfort. However, in some dogs, this immune modulation can temporarily affect their energy levels, leading to tiredness or less engagement in activities they once enjoyed.
Rule out underlying issues: Although mild lethargy can be a side effect of Apoquel, it’s important to rule out any underlying issues. Lethargy could also be a sign of infections or other conditions, as Apoquel has immune-suppressing effects that can make dogs more prone to infections. A thorough check-up with your vet is crucial if the lethargy persists or worsens.
Dosage adjustments: If the lethargy is consistent and troubling, it may be worth discussing a dosage adjustment with your vet. Sometimes a lower dose can maintain the desired effect of the medication without causing too much fatigue.

💡 Pro Tip: Track your dog’s energy levels and any other symptoms in a daily journal. This will provide valuable information to your vet when evaluating whether Apoquel is the best treatment option for your dog.

Comment 2: “My dog developed diarrhea shortly after starting Apoquel. Could the medication be causing this, and what should I do?”

Yes, diarrhea can be one of the gastrointestinal side effects of Apoquel. While it’s not common, some dogs experience digestive upset as their body adjusts to the medication. Here’s how you can handle this:

Mild digestive upset: If the diarrhea is mild and your dog is otherwise behaving normally, you can manage the issue by switching to a bland diet (boiled chicken and rice) for a few days to help settle their stomach. Often, the digestive system adjusts after the initial 2-3 weeks of treatment, and diarrhea subsides.
Monitor hydration: If your dog has diarrhea, make sure they’re drinking enough water to stay hydrated. Increased thirst can also be a side effect of Apoquel, so it’s essential to ensure your dog isn’t losing too much fluid through frequent bowel movements.
When to contact your vet: If the diarrhea persists for more than a couple of days, worsens, or is accompanied by vomiting, lethargy, or a loss of appetite, it’s time to contact your vet. In some cases, Apoquel may not be the best fit for dogs with sensitive stomachs, and your vet may suggest adjusting the dosage or trying an alternative medication.

💡 Pro Tip: Adding a probiotic to your dog’s diet can help restore healthy gut bacteria and may reduce the likelihood of ongoing digestive issues while on Apoquel.

Comment 3: “Is it safe to use Apoquel long-term, or should I be worried about suppressing my dog’s immune system?”

The safety of long-term Apoquel use has been a topic of concern for many dog owners, particularly because of its immune-suppressing properties. While Apoquel is generally considered safe for long-term use in managing allergies, there are some important factors to keep in mind:

Immune suppression risks: Apoquel works by targeting cytokines, which play a role in both inflammation and immune response. Over time, this suppression can make your dog more vulnerable to infections, particularly skin infections, urinary tract infections, or respiratory issues. Dogs on long-term Apoquel should be monitored for any signs of illness.
Tumor growth: There have been concerns about a possible increased risk of tumors with long-term Apoquel use. While the studies are not definitive, and the risk remains low, it’s still a consideration for dogs already prone to cancers or benign growths. Regular veterinary exams are essential to catch any changes early.
Periodic vet check-ups: If your dog is using Apoquel long-term, regular check-ups are critical. These appointments allow your vet to perform blood tests, check for infections, and monitor your dog’s overall health while on the medication.

💡 Pro Tip: Consider discussing Cytopoint with your vet as a possible alternative for long-term allergy control. Cytopoint is an injectable that works differently from Apoquel and may offer a safer long-term solution for dogs at higher risk of immune-related side effects.

Comment 4: “Can I switch my dog from Apoquel to something more natural like supplements or diet changes? Will that be enough to manage their allergies?”

Transitioning your dog to more natural treatments for allergies is possible, but whether it will be effective depends on the severity of their symptoms. Here’s what to consider:

Omega-3 fatty acids: Supplements like fish oil or krill oil are rich in Omega-3 fatty acids, which have natural anti-inflammatory properties. They can reduce itching and inflammation over time, though results may not be as immediate as with Apoquel. Omega-3s are great for dogs with mild to moderate allergies.
Quercetin: Known as “nature’s Benadryl,” quercetin is a natural bioflavonoid that has anti-inflammatory and antihistamine properties. It’s often used as a natural alternative to medications for dogs with mild seasonal allergies.
Hypoallergenic diet: Some dogs with food sensitivities can experience significant allergy relief from switching to a limited-ingredient diet or a novel protein like duck or venison. This could help reduce the need for medications if your dog’s allergies are food-related.
Cytopoint: For dogs with moderate to severe allergies, a natural-only approach may not be enough. Cytopoint is a great non-drug alternative to Apoquel. It’s an injectable treatment that targets itch-inducing cytokines and can be used long-term without the immune-suppressing effects of Apoquel.

💡 Pro Tip: If you’re thinking of transitioning to natural treatments, do it gradually while under the guidance of your vet. You may need to use a combination of natural supplements, diet changes, and Cytopoint injections to fully manage your dog’s allergies without Apoquel.

Comment 5: “What should I do if my dog’s itching returns after I stop giving them Apoquel? Is there a way to prevent flare-ups?”

If your dog’s itching returns after stopping Apoquel, it’s likely due to a flare-up of their underlying allergies. Here’s how to handle this situation:

Weaning off Apoquel: If you stop Apoquel suddenly, your dog’s symptoms could come back stronger. It’s important to wean off the medication gradually, under the guidance of your vet, to minimize the chance of a severe rebound in symptoms.
Manage the environment: Allergies can be triggered by environmental factors like pollen, dust, or mold. Try reducing allergens in your home by using air purifiers, cleaning bedding frequently, and wiping down your dog’s paws after walks to remove pollen.
Use topical treatments: To provide immediate relief from itching, you can use hypoallergenic shampoos, oatmeal baths, or anti-itch sprays. These treatments can help soothe your dog’s skin during flare-ups and reduce the need for oral medications.
Explore alternative medications: If Apoquel isn’t right for your dog, but their symptoms are too severe for a natural approach alone, Cytopoint or antihistamines (like Benadryl) may help manage their itching without as many side effects. Your vet can recommend the best course of action based on your dog’s specific condition.

💡 Pro Tip: After discontinuing Apoquel, regular vet check-ups are essential to monitor your dog’s skin health and adjust their treatment plan as needed. Early intervention during flare-ups can prevent symptoms from getting worse.

Comment 6: “My dog’s coat seems thinner since starting Apoquel. Is hair thinning a known side effect, and what should I do about it?”

While hair thinning is not one of the most commonly reported side effects of Apoquel, it’s possible that your dog is experiencing this due to either immune suppression or an underlying infection that the medication has made your dog more susceptible to.

Immune suppression: Apoquel works by targeting the immune system, and in some dogs, this can affect skin and coat health. Thinning fur may occur if your dog is developing a mild skin infection or if their immune system isn’t responding as well to normal skin irritations.
Secondary infections: Dogs on Apoquel are slightly more prone to bacterial or fungal infections, which can lead to issues like alopecia (hair loss). It’s important to monitor their skin for any signs of redness, scaling, or bald patches and to consult your vet for appropriate treatments if needed.
Nutritional support: To improve coat health while your dog is on Apoquel, you can supplement their diet with Omega-3 fatty acids and biotin, both of which are known to support healthy skin and fur. Regular grooming and hypoallergenic shampoos may also help improve the texture and thickness of their coat.

💡 Pro Tip: If your dog’s coat continues to thin, or if you notice other signs of skin infection, talk to your vet about a possible switch to a different allergy management solution, like Cytopoint, which may be less likely to affect their coat.

Comment 7: “Since taking Apoquel, my dog seems to be more prone to infections. Is this linked to the medication, and should I be worried?”

Yes, increased susceptibility to infections can be linked to Apoquel. Because the medication works by modulating the immune system, it can sometimes suppress the body’s natural defense mechanisms, making your dog more prone to skin infections, ear infections, or even urinary tract infections (UTIs). Here’s why and what you should look out for:

How Apoquel affects the immune system: Apoquel targets specific proteins (cytokines) that are responsible for the inflammatory response associated with allergies. However, these same proteins also play a role in the immune system’s ability to fight off infections. With this pathway partially blocked, your dog might not respond as quickly to bacterial or fungal invaders.
Common infections in dogs on Apoquel: Dogs on Apoquel may experience a higher incidence of pyoderma (bacterial skin infections), otitis (ear infections), or hot spots due to immune suppression. It’s important to monitor for symptoms such as red, inflamed skin, itching, discharge from the ears, or frequent urination, as these could be signs of infection.
What to do: If your dog develops recurrent infections while on Apoquel, consult your vet. They might recommend regular skin checks, or in some cases, adjusting the dosage or considering an alternative treatment. Cytopoint, for instance, doesn’t suppress the immune system as much and might be a safer option for dogs prone to infections.

💡 Pro Tip: Boost your dog’s immune system with a high-quality diet rich in Omega-3s, probiotics, and antioxidants to support overall health while on Apoquel. Adding these to your dog’s daily routine can help counterbalance the immune suppression.

Comment 8: “Apoquel worked wonders for my dog’s itching, but now they seem to be gaining weight. Could this be a side effect of the medication?”

Weight gain itself is not a direct side effect of Apoquel, but there are indirect ways in which the medication could be contributing to your dog’s weight gain:

Reduced activity levels: If Apoquel has successfully reduced your dog’s itching and discomfort, they may be less active than usual because they’re not spending energy on excessive scratching or restlessness. It’s possible your dog’s daily activity levels have decreased without you noticing, leading to weight gain over time.
Increased appetite: Some owners report that dogs on Apoquel may exhibit a slight increase in appetite, potentially due to the immune-modulating effects of the medication. This could lead to overfeeding or more frequent begging for treats.
Managing weight gain: Keep an eye on your dog’s portion sizes and overall calorie intake. You can switch to a lower-calorie dog food or incorporate more exercise into their routine, like short walks or interactive play, to help manage their weight.

💡 Pro Tip: Consider weighing your dog every few weeks to track any changes. This allows you to catch any potential weight gain early and adjust their food or exercise routine accordingly.

Comment 9: “How does Apoquel compare to steroids for treating my dog’s allergies? I’ve heard steroids have more side effects.”

Apoquel and steroids (like prednisone) are both commonly used to treat allergies in dogs, but there are important differences between the two in terms of how they work and their side effect profiles:

Apoquel: Targets specific cytokines involved in the allergic response. It provides fast relief from itching without the broad immune suppression seen in steroids. It’s considered safer for long-term use compared to steroids, as it carries fewer systemic side effects, like excessive thirst or weight gain.
Steroids: Steroids are more potent in terms of reducing inflammation but come with a higher risk of side effects, especially with long-term use. Steroids can lead to issues such as excessive thirst, weight gain, muscle wasting, and even diabetes if used over extended periods.
Safety comparison: While steroids can be highly effective for short-term relief of severe allergic reactions, they are generally not recommended for long-term use due to the potential for serious side effects. Apoquel, on the other hand, is better tolerated and more suitable for long-term management of chronic allergies.

💡 Pro Tip: If your dog has been on steroids and you’re looking for a safer long-term option, transitioning to Apoquel or Cytopoint could provide similar relief with fewer side effects. Always consult your vet to ensure a smooth transition between medications.

Comment 10: “What should I expect if I switch my dog from Apoquel to Cytopoint? Are there any major differences in how they work?”

Switching from Apoquel to Cytopoint can be a good option, especially if you’re looking for a non-oral medication or something with fewer concerns about long-term use. Here’s how the two compare and what to expect:

Mechanism of action: While Apoquel is a daily oral medication that targets cytokines involved in both itching and immune responses, Cytopoint is a biologic injection that specifically targets IL-31, a cytokine that plays a key role in itching. Cytopoint is much more targeted, which means it doesn’t suppress the immune system as broadly as Apoquel does.
Duration: Cytopoint provides relief for 4-8 weeks per injection, making it a longer-lasting option for managing chronic itching without the need for daily pills. For dogs that dislike taking medication or for owners who find daily dosing difficult, Cytopoint offers more convenience.
Side effects: Cytopoint has fewer reported side effects compared to Apoquel. Since it doesn’t suppress the immune system as much, it’s often seen as a safer option for dogs with underlying health concerns or for those that have experienced side effects from Apoquel.

💡 Pro Tip: Cytopoint may be particularly effective for dogs that have seasonal allergies or those who need long-term management of itching without the risk of immune suppression. Consult with your vet to see if it’s the right fit for your dog.

Comment 11: “What should I do if Apoquel isn’t controlling my dog’s itching as well as it used to?”

If you’ve noticed that Apoquel is no longer as effective in controlling your dog’s itching, it could be due to several factors. Here’s what you can do to address this issue:

Allergy flare-ups: Environmental factors, such as seasonal allergens like pollen, can lead to flare-ups that may overwhelm Apoquel’s usual effectiveness. During these times, your dog may need additional support like a topical anti-itch spray or antihistamines to help manage symptoms.
Titrate dosage: Depending on your dog’s condition, your vet may recommend adjusting the dosage of Apoquel. Some dogs may require a temporary increase in dosage during peak allergy seasons or after exposure to new allergens.
Reassess underlying causes: If Apoquel’s effectiveness has diminished, it might be time to reassess the underlying cause of your dog’s allergies. Conducting allergy tests or performing a food elimination diet can help identify whether new allergens are at play and whether a different treatment plan is necessary.
Consider Cytopoint or combination therapy: If Apoquel is no longer working as effectively, you could discuss combination therapy with your vet. This might involve adding Cytopoint injections alongside Apoquel or transitioning to Cytopoint entirely for better control over severe itching.

💡 Pro Tip: Regular check-ins with your vet are essential if you notice changes in Apoquel’s effectiveness. Keeping track of seasonal patterns or environmental exposures can help your vet tailor a more precise treatment plan for your dog’s allergies.

Comment 12: “I’m concerned about the long-term cost of Apoquel. Are there more affordable options that are just as effective?”

Apoquel can be expensive, especially for larger dogs or for long-term use. However, there are some options that may help manage the cost without sacrificing effectiveness:

Cytopoint injections: While Cytopoint can also be pricey, the fact that it is administered every 4-8 weeks instead of daily can make it a more cost-effective option for some owners. The convenience of fewer doses might balance out the cost, especially for dogs that need chronic allergy management.
Antihistamines: Over-the-counter antihistamines like Benadryl or Zyrtec can sometimes be used in combination with or as a replacement for Apoquel in dogs with milder allergy symptoms. These options are significantly cheaper but may not provide the same level of relief for dogs with severe allergies.
Generic options: While there isn’t a direct generic form of Apoquel yet, always ask your vet if there are alternative treatments that could offer similar results at a lower cost. Certain compounded versions or natural supplements might be less expensive while still effective.

💡 Pro Tip: Look into pharmacy discount programs or veterinary subscription services that offer discounts for recurring Apoquel prescriptions. Buying in bulk or asking about manufacturer rebates can also help reduce the long-term cost of this medication.

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Published on: October 2, 2024October 2, 2024Author: Bestie PawsLike: 4Comment: 0