Side Effects of Revolution Plus for Cats

When it comes to protecting our feline friends from parasites, Revolution Plus has become a popular choice among pet owners. However, like any medication, it comes with its share of potential side effects. This comprehensive guide aims to provide pet owners with crucial information regarding the side effects of Revolution Plus, helping you make an informed decision about your cat’s health.

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What is Revolution Plus?

Revolution Plus is a broad-spectrum topical solution used for the prevention and treatment of various parasitic infections in cats. It contains two active ingredients: selamectin and sarolaner. While it is highly effective in eliminating parasites such as fleas, ticks, ear mites, roundworms, and hookworms, it is crucial to be aware of the potential side effects that may occur.

Potential Side Effects of Revolution Plus for Cats

To provide a clear understanding, we have compiled a detailed table chart outlining the potential side effects based on different studies and post-approval experiences:

Adverse Reaction REVOLUTION PLUS (Based on Studies) Post-Approval Reports (2022)
Lethargy ✔️ (4.3%) ✔️
Skin Lesions ✔️ (3.5%)
Anorexia ✔️ (3.2%) ✔️
Pruritus (Itching) ✔️ (2.5%) ✔️
Conjunctivitis (Eye Inflammation) ✔️ (2.5%)
Sneezing ✔️ (2.1%)
Alopecia (Hair Loss) ✔️ (1.8%) ✔️
Scabbing at Application Site ✔️ (0.7%)
Vomiting ✔️
Generalized Alopecia ✔️
Behavioral Disorders ✔️
Ataxia (Loss of Muscle Coordination) ✔️
Muscle Tremor ✔️
Diarrhea ✔️
Seizure ✔️

Key Takeaways:

1. Be Vigilant of Neurological Reactions

Sarolaner, an ingredient in Revolution Plus, belongs to the isoxazoline class, which has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Special caution should be exercised for cats with a history of neurologic disorders.

2. Monitor for Gastrointestinal and Dermatological Issues

Some cats may experience gastrointestinal issues such as vomiting and diarrhea, as well as dermatological issues including skin lesions and alopecia.

3. Observe Behavioral Changes

Pay attention to any unusual behavioral changes in your cat, such as hiding, hyperactivity, or increased vocalization, as these could be indicative of an adverse reaction.

4. Age and Health Status Matter

Revolution Plus has not been evaluated for safe use in kittens less than 8 weeks of age, as well as in breeding, pregnant, or lactating cats. Ensure your cat meets the age and health requirements before administration.

5. Know When to Contact a Professional

If you observe any adverse reactions in your cat after administering Revolution Plus, contact your veterinarian immediately. Reporting adverse reactions is crucial for monitoring the product’s safety.


Revolution Plus is a powerful tool in the fight against feline parasites, but it is essential to be aware of the potential side effects and monitor your cat’s reaction closely. By staying informed and vigilant, you can help ensure the health and well-being of your furry friend. Remember, when it comes to your pet’s health, it’s always better to be safe than sorry!


1. What is Revolution Plus, and how does it work for cats?

Revolution Plus is a topical solution designed to protect cats from parasites such as fleas, ticks, ear mites, and various worms. Its active ingredients, selamectin and sarolaner, work synergistically to interfere with the nervous system of the parasites, leading to their rapid death and elimination from the cat’s body. Selamectin is well-known for its efficacy against a broad spectrum of parasites, while sarolaner specifically targets ticks and fleas with its fast-acting properties.

2. How often should I administer Revolution Plus to my cat?

Revolution Plus is formulated to provide one month of protection per dose. Therefore, it is recommended to apply the solution once a month, following your veterinarian’s advice. Consistent monthly application ensures continuous protection against parasites and decreases the likelihood of infestation.

3. Can I use Revolution Plus on my kitten?

Revolution Plus is not tested or approved for use on kittens less than 8 weeks of age. For kittens younger than this, it is crucial to seek alternative treatments and consult with a veterinarian to ensure their safety and well-being.

4. Are there any specific storage instructions for Revolution Plus?

Yes, it is essential to store Revolution Plus in a cool, dry place away from direct sunlight and out of reach of children and pets. The recommended storage temperature is between 59°F and 86°F (15°C and 30°C). Proper storage ensures the efficacy and safety of the product.

5. How do I apply Revolution Plus to my cat?

To apply Revolution Plus, part the fur at the base of your cat’s neck to expose the skin. Place the tip of the tube on the skin and squeeze it firmly to empty the contents in one spot. Ensure that the solution is applied directly to the skin, not on the fur, to facilitate proper absorption.

6. Can Revolution Plus be used on pregnant or lactating cats?

The safety of Revolution Plus has not been established in breeding, pregnant, or lactating cats. If your cat is in any of these categories, it is crucial to consult with a veterinarian before using the product to ensure it is safe for both the mother and her offspring.

7. What should I do if my cat experiences an adverse reaction after using Revolution Plus?

If you notice any signs of adverse reactions such as lethargy, skin irritation, or gastrointestinal issues, contact your veterinarian immediately. In the event of a severe reaction, such as seizures or persistent vomiting, seek emergency veterinary care.

8. Can Revolution Plus be used alongside other medications?

If your cat is on other medications, inform your veterinarian before using Revolution Plus. While it is generally considered safe to use with other treatments, potential interactions should be evaluated to ensure your cat’s safety.

9. Is there anything I should avoid doing after applying Revolution Plus?

After applying Revolution Plus, avoid bathing your cat or allowing them to swim for at least two hours, as this could reduce the effectiveness of the product. Additionally, keep treated pets away from untreated pets until the application site is dry to prevent accidental ingestion or transfer of the product.

10. How does Revolution Plus compare to other flea and tick preventatives?

Revolution Plus offers a broader spectrum of protection compared to some other flea and tick preventatives, thanks to its combination of active ingredients. It not only targets fleas and ticks but also addresses internal parasites and ear mites, providing comprehensive coverage for your cat’s health. However, as with any medication, individual cat responses can vary, and it’s important to choose a product that suits your pet’s specific needs and health status. Always consult with a veterinarian to determine the most appropriate and safe option for your cat.

11. Can Revolution Plus protect against heartworm disease in cats?

Yes, Revolution Plus has proven efficacy in protecting against heartworm disease in cats. The active ingredient selamectin plays a vital role in preventing heartworm larvae from developing and maturing into adult worms, which can cause severe health issues and even be fatal. Regular monthly applications are necessary to maintain continuous protection, and it is crucial to consult with a veterinarian for proper heartworm testing and guidance before starting the preventive regimen.

12. How does Revolution Plus impact the environment?

The ingredients in Revolution Plus, like selamectin and sarolaner, are potent chemicals that effectively target parasites. However, their environmental impact should not be overlooked. Residues from the product can potentially enter water systems if cats groom themselves and then lick their paws or fur, transferring the chemical residues. While the concentrations are typically low, ongoing monitoring and research are vital to understanding the long-term implications and ensuring eco-friendly practices are in place.

13. Can Revolution Plus cause side effects in certain breeds of cats?

Revolution Plus is generally safe for all breeds of cats when used according to the product’s guidelines. However, individual sensitivities can vary, and some cats may exhibit reactions not commonly observed in the broader feline population. It is always recommended to monitor your cat after application and report any unusual symptoms to your veterinarian immediately. In cases of known sensitivities or previous reactions, discussing alternative preventive options with your veterinarian is advisable.

14. What are the active ingredients in Revolution Plus, and how do they differ from the original Revolution formula?

Revolution Plus contains two active ingredients: selamectin and sarolaner. Selamectin is a broad-spectrum parasiticide that targets both external and internal parasites, while sarolaner is a newer ingredient that specifically enhances the product’s efficacy against ticks and fleas. Compared to the original Revolution formula, which solely contains selamectin, Revolution Plus offers an expanded range of protection, particularly in areas where tick infestations are prevalent.

15. How does the dosage of Revolution Plus vary based on a cat’s weight?

The dosage of Revolution Plus is carefully calibrated based on a cat’s weight to ensure optimal efficacy while minimizing the risk of adverse reactions. The product comes in different packaging, color-coded to correspond with specific weight ranges. Ensuring you use the correct dose for your cat’s weight is imperative for the product to work effectively and safely.

16. Can I use Revolution Plus on a cat with a known skin condition?

If your cat has a pre-existing skin condition, it is essential to consult with a veterinarian before applying Revolution Plus. The application site requires direct contact with the skin, and applying the product on irritated or broken skin could potentially exacerbate the condition or lead to adverse reactions.

17. Is it possible for fleas or ticks to become resistant to Revolution Plus?

Parasite resistance to medications is a concern within veterinary medicine, and ongoing research is crucial to monitor and understand these patterns. While there are no widespread reports of fleas or ticks developing resistance to the active ingredients in Revolution Plus, responsible use of the product and integrated pest management strategies play a vital role in minimizing the risk of resistance.

18. Can indoor cats benefit from Revolution Plus, or is it only necessary for outdoor cats?

Even indoor cats can benefit from the protection offered by Revolution Plus. Fleas, ticks, and other parasites can enter homes through various means, posing a risk to all cats, regardless of their lifestyle. Additionally, Revolution Plus protects against internal parasites and ear mites, which can affect cats irrespective of their access to the outdoors.

19. Is there a recommended season for using Revolution Plus, or should it be used year-round?

Parasites such as fleas and ticks can be active in various seasons, depending on the geographical location and climate. In some areas, year-round protection is essential due to persistent parasite activity, while in other regions, seasonal application may be sufficient. Consulting with a local veterinarian will provide guidance tailored to the specific risks in your area, ensuring your cat remains protected throughout the year.

20. How can I ensure the authenticity of the Revolution Plus product I purchase?

Ensuring you purchase Revolution Plus from reputable sources, such as licensed veterinarians or authorized retailers, is crucial for receiving an authentic product. Counterfeit products pose significant risks, potentially leading to ineffective protection or adverse reactions. If the packaging appears tampered with or the product seems unusual in any way, do not use it and contact the manufacturer or a veterinarian for verification.

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