Apoquel and Benadryl: Can Dogs Take Apoquel and Benadryl Together?

If you’re thinking of giving your dog Apoquel and Benadryl together, it’s important that you understand how they interact.

Apoquel and Benadryl together for dogs

Can I give my dog Apoquel and Benadryl together?

Yes, you can give your dog Benadryl and Apoquel at the same time. However, it is not recommended to use these two medications together as they both have some similarities in their functions.

Benadryl is a common antihistamine that can be given to dogs with allergies or other conditions. The drug works by blocking histamine, a chemical produced by the body that causes allergic reactions.

Apoquel is an immunosuppressant drug used to treat dogs with chronic canine atopic dermatitis (a form of eczema). It works by suppressing inflammatory responses and decreasing itching.

There are no known drug interactions between these two medications. However, there are some side effects that are worth noting. Dogs taking both Benadryl and Apoquel may experience drowsiness, restlessness, irritability, lack of appetite, and vomiting.

Both medications are safe to use as long as you follow your veterinarian’s instructions carefully.

What drugs should not be taken with Apoquel?

Apoquel should not be used in dogs that are on cortisone-type medications, such as prednisone, or Atopica® (cyclosporine), as it can cause undesired side effects.

The manufacturer of Apoquel states that it should not be given with other drugs that affect the immune system. The reason for this precaution is that corticosteroids suppress the immune system by reducing inflammatory responses and increasing the risk of infection in dogs with compromised immune systems.

If your dog has a compromised immune system due to another medical condition (such as cancer), talk to your veterinarian about whether it is safe for him to take Apoquel or if he needs to be taken off it temporarily while being treated for his other condition.

Can Apoquel be used with other medications?

Apoquel can be used along with:

  • Antibiotics
  • Antifungals
  • Anti-arthritis drugs
  • Allergy shots
  • Flea/tick/heartworm preventives
  • Thyroid supplements
  • Seizure medications

Apoquel may be used alone or with other medications to treat your dog’s atopic dermatitis. However, it is important to remember that no drug works for every dog and there will always be some cases where this medication will not work effectively. In these situations, you should talk with your veterinarian about trying other treatments such as corticosteroids or antibiotics.

Can I give my dog Apoquel and Zyrtec together?

Yes, you can give your dog Apoquel and Zyrtec together. However, it is not recommended that you do so. The combination of these drugs can result in undesired side effects for your pet including vomiting and diarrhea.

Can I give my dog Apoquel and Gabapentin together?

Yes, you can give your dog Apoquel and Gabapentin together. You can give these two medications together safely if your pet has been prescribed them by a veterinarian.

Gabapentin is an anticonvulsant (anti-seizure) medication that is used to manage seizures and pain caused by damaged nerves. It comes in capsule form and is sometimes given as part of a combination treatment with other medications.

Alternative to Apoquel for dogs

There are a number of natural alternatives for Apoquel that you can use for your dog, including:

1. Quercetin

Quercetin is an antioxidant that’s been shown to help with allergies and asthma. It’s found in many fruits and vegetables, including apples, onions, citrus fruits, and berries. Quercetin may also have anti-inflammatory effects on the skin and decrease allergic reactions.

2. Chamomile

Chamomile tea has traditionally been used for many ailments including insomnia, anxiety, stomach upset, inflammation and skin problems. In addition to its relaxing effects on the body, it also contains anti-inflammatory properties which can help with allergy symptoms.

3. Green tea

Green tea is a great solution for dogs who are suffering from allergies. It has been used by humans for centuries to help with various ailments, including allergies. Green tea contains catechins and tannins, both of which have proven antihistamine properties. The best part is that green tea is completely safe for your dog to consume!

4. Calendula

Calendula is also known as marigold and can be found in most pet stores. Calendula flowers are easy to grow and can be used fresh or dried in tinctures or capsules. Calendula has been shown to have strong anti-inflammatory properties, making it an excellent treatment option for dogs suffering from allergies.

5. Oatmeal Baths

Oatmeal baths are one of the most common treatments for dogs suffering from skin allergies and other skin conditions. Oatmeal helps relieve itching by moisturizing dry skin and reducing inflammation in the body. The best type of oatmeal to use in an oatmeal bath is colloidal oatmeal (oatmeal made into a fine powder).

6. Aloe Vera Gel

Aloe vera gel can be applied directly to a dog’s skin or coat in order to reduce itching. Aloe vera gel is also known for its anti-inflammatory properties, which makes it an effective treatment for many types of skin conditions including allergies and flea allergies. It also contains antibacterial agents that can help treat minor cuts and scrapes.

7. Fish oil

Some studies have found that fish oil may be effective at reducing the symptoms of allergies and asthma, such as itching and sneezing. However, the results were inconsistent between studies and more research is needed before any definitive conclusions can be made.

Conclusion of Apoquel and Benadryl together for dogs

There is no conclusive evidence that the two drugs in combination are dangerous for dogs. These two drugs have different mechanisms of action, so it’s unlikely they will have a negative interaction.

However, you should never give your dog any medication without consulting with your veterinarian first. The vet may be able to recommend another treatment option or dosage adjustment that will help your dog without the risk of side effects from combining medications.

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Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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