Trifexis vs Simparica Trio Cost

Pet owners often face the challenging task of selecting the best preventative medication for their furry friends. This article compares two leading choices for comprehensive parasite protection: Trifexis and Simparica Trio. Understanding these products’ costs and effectiveness will help pet owners make the best choice for their dogs’ health and their budget.

Understanding Trifexis and Simparica Trio

Before comparing costs, let’s understand what each product offers.

Trifexis: This once-monthly chewable tablet for dogs offers protection against fleas, heartworms, and three types of intestinal parasites: roundworms, hookworms, and whipworms.

Simparica Trio: A chewable tablet that, like Trifexis, is administered monthly. Simparica Trio provides broader coverage, protecting against fleas, ticks, heartworms, roundworms, and hookworms.

Cost Comparison: Trifexis vs Simparica Trio

The cost of these medications varies widely, depending on your location, the size of your dog, and where you buy them.

The average cost for a six-month supply of Trifexis ranges from $100 to $120, while Simparica Trio can cost around $130 to $160. Note that these prices may have changed, and it’s best to check with local retailers or veterinary clinics for current prices.

Online Retailers: Sites like Chewy often offer competitive prices. For example, as of 2022, a six-month supply of Trifexis was priced at $127 on Chewy, while Simparica Trio was $168.

Costco: You may find lower prices at Costco, according to various Reddit users. As of 2022, one user reported a Simparica Trio quote at around $30-$40 less than their vet’s prices.

Evaluating Cost-effectiveness

While the cost is a significant factor, it’s also essential to consider each product’s coverage. Simparica Trio covers ticks, a common parasite not covered by Trifexis. If you live in a tick-infested area, Simparica Trio might be the better, albeit pricier, option. However, if ticks are not a concern for you, Trifexis could offer substantial savings without compromising your dog’s health.

Additional Considerations

Many users report both Trifexis and Simparica Trio to be effective and easy to administer, with a flavor most dogs enjoy. Still, it’s vital to discuss with your vet before making a decision. Each dog is unique and may react differently to medication. Factors such as the dog’s health, age, size, and environment should be taken into account.


When it comes to Trifexis vs Simparica Trio, both are excellent products offering broad parasite protection. However, Simparica Trio’s higher price reflects its broader coverage, including tick prevention. If your priority is cost-saving, Trifexis could be the ideal choice, given that it covers the major parasites, excluding ticks. As always, consult your vet before deciding on any medication for your beloved pet.

Frequently Asked Questions

1. What is the active ingredient in Trifexis and Simparica Trio?

Trifexis combines two powerful active ingredients: Spinosad, an insecticide that kills fleas, and Milbemycin Oxime, an antiparasitic agent effective against heartworms, roundworms, hookworms, and whipworms.

On the other hand, Simparica Trio consists of three active components: Sarolaner, an insecticide and acaricide that kills fleas and ticks; Moxidectin, effective against heartworms and certain intestinal worms; and Pyrantel Pamoate, another antiparasitic effective against roundworms and hookworms.

2. Can Trifexis and Simparica Trio be used together?

Administering two potent medications simultaneously may lead to adverse effects or drug interactions. As Trifexis and Simparica Trio share some common elements, it’s usually unnecessary and potentially risky to use both. Always consult your vet before introducing or combining any medications.

3. How quickly do Trifexis and Simparica Trio start working?

Trifexis starts killing fleas within 30 minutes of administration and achieves 100% effectiveness within four hours. Simparica Trio, on the other hand, begins killing fleas and ticks within 3 hours and reaches maximum efficiency within 8 hours.

4. What are the possible side effects of Trifexis and Simparica Trio?

Common side effects for both medications include vomiting, diarrhea, loss of appetite, and lethargy. It’s crucial to observe your dog after administering the medication and report any unusual behavior to your vet immediately.

5. Can puppies take Trifexis and Simparica Trio?

Trifexis is safe for puppies aged 8 weeks and older, weighing at least 5 pounds. Simparica Trio can be administered to puppies as young as 8 weeks old, provided they weigh at least 2.8 pounds. However, always consult your vet before starting any new medication, especially for young puppies.

6. Can pregnant or breeding dogs take Trifexis and Simparica Trio?

Trifexis has not been evaluated for safety in breeding females. Simparica Trio, on the other hand, has been tested and found safe for breeding, pregnant, and lactating dogs. As with any medication, it’s important to consult your vet before administering it to pregnant or breeding dogs.

7. How should I store Trifexis and Simparica Trio?

Both medications should be stored in a dry place at room temperature, away from light. It’s also important to keep them out of reach of children and pets to prevent accidental ingestion.

8. How are Trifexis and Simparica Trio administered?

Both Trifexis and Simparica Trio are oral medications, typically given once a month. These medications are conveniently flavored, making administration easier. However, some dogs may still resist taking the medication, in which case it can be hidden in a treat or a small amount of food.

9. Can my dog develop resistance to Trifexis or Simparica Trio?

While resistance is a complex issue and can occur with any medication over time, there are currently no widely recognized reports of resistance to the active ingredients in Trifexis or Simparica Trio. Consistent, regular use as directed by a veterinarian is the best way to ensure the effectiveness of these products.

10. Do I need a prescription for Trifexis and Simparica Trio?

Yes, both Trifexis and Simparica Trio are prescription medications. This means they must be prescribed by a licensed veterinarian after a thorough health checkup of your dog.

11. Are there breed-specific considerations for using Trifexis or Simparica Trio?

While these medications are generally safe for all breeds when used as directed, some dogs may experience side effects. Also, certain breeds may be more susceptible to negative reactions. Dogs with a history of seizures or neurological disorders, for instance, might require additional monitoring.

12. Do Trifexis and Simparica Trio treat the same parasites?

While both products provide protection against fleas and worms, there’s a notable difference. Simparica Trio also protects against ticks, an advantage for pet owners in areas where tick-borne diseases are common.

13. Can I bathe my dog after administering Trifexis or Simparica Trio?

Since both Trifexis and Simparica Trio are oral medications, their efficacy won’t be affected by bathing or swimming. This offers an advantage over some topical flea and tick preventatives.

14. Can Trifexis and Simparica Trio be used in pregnant or lactating dogs?

The safety of Trifexis in breeding, pregnant, or lactating dogs hasn’t been evaluated. However, Simparica Trio is deemed safe for use in breeding, pregnant, and lactating dogs. Nonetheless, it’s crucial to consult your vet before administering these medications to a pregnant or lactating dog.

15. How long does it take for Trifexis and Simparica Trio to work?

Both Trifexis and Simparica Trio start killing fleas within 2 hours of administration, with a 100% efficacy at 4 hours for Simparica Trio and 24 hours for Trifexis. For heartworm prevention, remember that both products should be administered monthly without interruption to ensure optimal protection.

16. What should I do if I miss a dose of Trifexis or Simparica Trio?

If you miss a dose, it’s recommended to administer the medication as soon as you remember and then continue with the regular schedule. Never administer two doses at once. In case of multiple missed doses, consult your veterinarian to ensure continuous protection against parasites.

17. Are there natural alternatives to Trifexis and Simparica Trio?

While there are natural remedies touted for flea, tick, and worm prevention, their effectiveness varies and is often less reliable than proven veterinary medications like Trifexis and Simparica Trio. Always discuss any alternative treatments with your vet to ensure your pet’s health and safety.

18. Can Trifexis and Simparica Trio be used alongside other medications?

Generally, both Trifexis and Simparica Trio can be safely used with other medications. However, drug interactions can occur, and therefore it is crucial to inform your vet of all medications and supplements your dog is currently taking.

19. Can Trifexis and Simparica Trio cause allergic reactions in dogs?

While rare, allergic reactions can occur. Symptoms might include itching, redness, swelling, or difficulty breathing. If your dog shows any signs of an allergic reaction, seek immediate veterinary care.

20. Can I use Trifexis or Simparica Trio for my cat?

No, Trifexis and Simparica Trio are specifically formulated for dogs and should not be used in cats. There are other products designed and tested for use in cats, which your vet can recommend based on your cat’s specific needs.

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