Apoquel vs Benadryl: Is Benadryl or Apoquel Better for Dogs?

Benadryl and Apoquel are both popular medications that can be used to control itching due to allergies in dogs. In this article, we will discuss the similarities and differences between these two medications.

Apoquel vs Benadryl for Dogs

Benadryl and Apoquel

Both Benadryl and Apoquel have similar purposes, but they are not the same thing.

Benadryl is an OTC medication that can be used as needed when your dog has an allergy attack while Apoquel is a long-term treatment for chronic itching due to atopic or allergic dermatitis.

Benadryl is an antihistamine and works by blocking histamine receptors in the body. Histamine is released by mast cells when they’re stimulated by allergens like pollen or dust mites. This causes allergy symptoms such as sneezing, itching, runny nose, and watery eyes.

Apoquel works by inhibiting a protein called canine cytokine interleukin-31 (cIL-31) which plays a role in the development of atopic dermatitis symptoms such as itching and scratching.

Apoquel vs Benadryl for dogs

The battle of Benadryl vs Apoquel is not a simple one.

Apoquel’s effectiveness is proven in studies and can be used long-term without negative effects. However, it does come with a higher price tag and it isn’t for all dogs.

Benadryl is cheap and easy to find. It’s usually safe for most dogs but doesn’t treat the underlying cause of your dog’s itchiness.

My personal recommendation is Apoquel for the most serious cases of chronic itching. If your dog doesn’t respond to it or if he suffers from side effects, Benadryl may be an effective backup option (assuming your dog does not have any contraindications).

The bottom line is that the drug you choose for your dog depends on what symptoms your pet is showing and how severe they are. If your dog is suffering from mild allergic reactions, then Benadryl may be the answer. If your dog has atopic or allergic dermatitis, then Apoquel may be the only thing that provides relief.

Benadryl for dogs reviews

Pet owners say Benadryl is a good medication for dogs with mild allergies. They also say that they are happy with the results they have gotten from using it. They say Benadryl works much better than other allergy medications that they have tried, so they plan to continue purchasing it.

Many people have found success using this product on their pets, especially when they are experiencing skin problems due to allergies. Some reviewers have tried using Benadryl instead of steroids for their dogs’ skin problems — they say it works just as well without causing side effects.

However, some reviewers say that their dogs still had reactions even when given Benadryl before being exposed to allergens such as pollen or mold spores.

“I gave my dog Benadryl for a week and he improved but the skin condition didn’t go away completely. His skin still itches but it’s not as bad as before. He also has more energy now!”

“I was afraid to try this on my dog because most of the reviews were bad, but I decided to give it a try anyway because nothing else seemed to work. I’m glad I did because after just two days of giving him this, his itching stopped and his fur started growing back! He’s been taking this for about two weeks now and I couldn’t be happier with this product!”

“Benadryl is the only product that works on my dog’s allergies. It helps him sleep at night because he doesn’t itch as much. I highly recommend this product!”

“I have used Benadryl on my dogs for many years and it works great for them. They don’t seem to have any side effects from it as they do from other allergy medications such as steroids.”

“This is an excellent product for my dog who suffers from seasonal allergies to grasses and weeds. It has kept him from scratching himself raw during the summer months when he is outside running around all day long.”

Apoquel for dogs reviews

Apoquel for dogs is a once-a-day oral treatment for dogs that can help control their itchiness. It is manufactured by Zoetis and approved by the FDA in 2013.

There are several customer reviews available online for Apoquel. Here’s what people have to say about their experience:

“I used this on my dog who was having issues with allergies and it worked wonders! My vet prescribed it for him and after the first dose he seemed much happier with his skin.”

“Apoquel is my saving grace! My dog has had severe allergies her entire life. When she was younger she was put on steroids which helped somewhat but as she got older they didn’t work anymore so I tried several other options including all-natural remedies but nothing worked until I tried Apoquel. This medicine has changed our lives! It’s been amazing watching her get better every day, she no longer scratches or bites herself and she doesn’t whine or cry anymore when she sees other dogs or people who might have allergies themselves (which was always terrible). I can’t thank them enough for creating such an amazing product!”

“This medicine works great for my dog’s allergy symptoms. It really reduces his itching and scratching, but he still sneezes occasionally and gets hives on occasion when outside.”

“I have a 5-year-old Golden Retriever who has been on Apoquel for about 6 months now. Her itching has gone down significantly and she rarely scratches anymore. We also noticed that her shedding has gone down as well! I highly recommend this medication if you’re looking for something safer than steroids.”

Can I buy Apoquel without a vet prescription?

You cannot buy Apoquel without a prescription from your vet.

If your dog is suffering from mild allergies, you can try using Benadryl to help ease the symptoms. However, keep in mind that Benadryl is not a cure for allergies, but rather a treatment that helps relieve symptoms.

What can I put on my dog to relieve itching?

If your dog is itching and scratching a lot, it’s never a bad idea to have some itch remedies.

  1. YuDERM Itching Dog| Itchy or Sensitive Skin Supplement for Dogs Prone to Scratching
  2. Leucillin Natural Antiseptic Spray | Antibacterial, Antifungal & Antiviral
  3. Vetericyn Wound and Skincare – Liquid Spray
  4. Pro Pooch Itchy Skin Dog Balm – For Dogs with Sensitive Skin – Helps Relieve Itching & Symptoms of Other Dry Skin Conditions
  5. Cooper & Gracie First Aid Antibacterial Itchy Skin Cream
  6. Anicura Natural Dog Gel Ointment for dry & itchy skin, hot spots, eczema & skin allergies
  7. Dog Skin Balm for Itchy Skin – Natural and Organic Ointment for Dogs – Itchy Dog Balm Safe for Licking
  8. Colloidal Silver Antiseptic Spray All-in-1 Treatment: Dogs & Cats – Skin Issues Relief (Itchy, Allergy, hotspot, Yeast, Dry)
  9. Petnat Dermacton Cream for ITCHY Dogs – Professionally recommended for itching & hair loss
  10. Davis Hydrocortisone Spray Pets
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Hannah Elizabeth is an English animal behavior author, having written for several online publications. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. When she isn't creating content for blog posts, Hannah enjoys long walks with her Rottweiler cross Senna, reading fantasy novels and breeding aquarium shrimp.

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