ProHeart 12 Dosing Chart

Heartworm disease is a serious and potentially fatal condition in dogs, caused by parasitic worms living in the heart and blood vessels of the lungs. A robust prevention strategy is crucial, and this is where ProHeart 12, an extended-release injectable suspension by Zoetis Inc., comes into play. In this article, we delve deep into understanding the dosing of ProHeart 12 to ensure your furry friend stays protected all year round.

What is ProHeart 12?

ProHeart 12 (moxidectin) is a medication used for preventing heartworm disease in dogs. It is administered as an injectable suspension and provides 12 months of protection with just one dose. Alongside heartworm prevention, it also treats existing larval and adult hookworm infections.

Who is it for?

ProHeart 12 is suitable for dogs 12 months of age and older, ensuring they stay heartworm-free for a year.

Why ProHeart 12?

Opting for ProHeart 12 is a choice many dog owners make for its convenience and long-lasting effects. It eliminates the need for monthly reminders, ensuring continuous protection against heartworms and hookworms.

Dosing Guide: Ensuring Accuracy

To guarantee your dog receives the correct dosage, it is vital to calculate each dose based on their current weight. Here’s a comprehensive dosing chart to help you along the way:

Dog Weight (lb) Dog Weight (kg) Dose Volume (mL/Dog)
11 5 0.25
22 10 0.50
33 15 0.75
44 20 1.00
55 25 1.25
66 30 1.50
77 35 1.75
88 40 2.00
99 45 2.25
110 50 2.50
121 55 2.75
132 60 3.00

*All dogs should be dosed at 0.05 mL suspension/kg body weight (0.023 mL/lb).

Key Takeaways

Accuracy is Key: Ensure the dose is calculated based on the dog’s current weight.

Veterinary Supervision: ProHeart 12 should only be administered under the guidance of a licensed veterinarian.

Prevention is Better Than Cure: Regular administration prevents heartworm disease, ensuring your dog stays healthy year-round.


Can ProHeart 12 Be Administered to Puppies or Younger Dogs?

ProHeart 12 is strictly recommended for use in dogs that are 12 months of age or older. The effectiveness and safety of the medication have not been established in puppies younger than this. Before administering ProHeart 12 to any dog, a comprehensive health assessment by a veterinarian is crucial to ensure the medication’s safety and efficacy.

What Precautions Should Be Taken for Dogs with Allergic Conditions?

Dogs with pre-existing allergic conditions such as food allergies, atopy, or flea allergy dermatitis should be given ProHeart 12 with caution. Since the medication can potentially trigger allergic reactions, close monitoring and a thorough evaluation by a veterinarian are essential to weigh the benefits and risks before administration.

How Does ProHeart 12 Interact with Vaccinations?

There have been reports of adverse reactions, including anaphylaxis, following the concurrent use of ProHeart 12 and vaccinations. While the medication can be administered alongside vaccinations, it requires a careful approach, ensuring the dog is closely monitored for any signs of adverse reactions.

Can ProHeart 12 Be Used More Frequently Than Every 12 Months?

ProHeart 12 is designed to provide 12 months of protection against heartworm disease and treatment of hookworm infections. Using the medication more frequently than every 12 months is not recommended, as the safety and efficacy of more frequent use have not been established.

What Should Be Done If a Dog Is Heartworm Positive?

Dogs tested positive for heartworms should undergo treatment with an adulticide to remove adult heartworms before considering ProHeart 12. ProHeart 12 is not effective against adult D. immitis, and caution should be exercised when administering the medication to heartworm positive dogs due to the potential for adverse reactions.

What Are The Common Adverse Reactions Associated with ProHeart 12?

Some of the commonly reported adverse reactions in dogs treated with ProHeart 12 include vomiting, lethargy, diarrhea, anorexia, seizures, and hypersensitivity reactions. Although these reactions are generally rare, immediate veterinary attention is required if any of these symptoms occur.

How Should ProHeart 12 Be Stored and Handled?

ProHeart 12 should be stored in a cool, dry place, away from direct sunlight and out of reach of children. Accidental exposure to the skin should be washed off thoroughly with water, and in case of accidental ingestion or eye exposure, immediate medical attention should be sought.

Can ProHeart 12 Be Administered Alongside Other Medications?

While there is no explicit prohibition against using ProHeart 12 with other medications, any additional medications or supplements being given to the dog should be disclosed to the veterinarian. This ensures that potential interactions can be assessed, and the dog’s safety is prioritized.

Is There Any Follow-Up Required After Administering ProHeart 12?

After the administration of ProHeart 12, the dog should be monitored for any signs of adverse reactions, especially within the first 24 hours. Additionally, regular veterinary check-ups are recommended to ensure the ongoing health and well-being of the dog and the effectiveness of the heartworm prevention program.

How Is ProHeart 12 Administered?

ProHeart 12 is administered as a subcutaneous injection, typically on the left or right side of the neck, cranial to the scapula. The dosage is calculated based on the dog’s body weight, ensuring accurate and safe administration. The veterinarian administering the medication will follow aseptic techniques and ensure the proper handling of the product.

Can ProHeart 12 Be Used in Breeding, Pregnant, or Lactating Dogs?

The safety of ProHeart 12 in breeding, pregnant, or lactating dogs has not been established. Any plans to breed a dog or if a dog is pregnant or lactating should be discussed with a veterinarian to determine the most appropriate and safe course of action.

How Does ProHeart 12 Differ from Other Heartworm Preventatives?

ProHeart 12 stands out from other heartworm preventatives primarily due to its extended duration of effectiveness, providing protection for a full 12 months with a single dose. This long-acting formulation distinguishes it from monthly preventatives, offering convenience and peace of mind to pet owners. It’s crucial to understand that while some other products may offer additional protection against a broader spectrum of parasites, ProHeart 12 specifically targets heartworm disease and hookworm infections.

Is There Any Breed-Specific Sensitivity to ProHeart 12?

Certain dog breeds may possess a genetic mutation (MDR1 gene mutation) making them more susceptible to adverse reactions from drugs like ProHeart 12. Breeds such as Collies, Australian Shepherds, and Long-Haired Whippets are commonly affected. It is imperative to conduct genetic testing or seek veterinary advice to ascertain the safety of administering ProHeart 12 to dogs of these breeds.

What Role Does Dog Weight Play in ProHeart 12 Dosage?

Accurate dosing of ProHeart 12 is contingent upon the precise body weight of the dog. The medication’s efficacy and safety are closely tied to proper dosage, underscoring the importance of a veterinary evaluation and weighing the dog prior to administration. Any discrepancies in weight calculations could result in under-dosing, rendering the product less effective, or overdosing, increasing the risk of adverse reactions.

Can ProHeart 12 Be Administered in Areas with Drug Resistance?

In regions where resistance to macrocyclic lactones (the drug class to which ProHeart 12 belongs) has been reported, ProHeart 12’s effectiveness might be compromised. Prior to choosing ProHeart 12, it is paramount to be aware of the local resistance patterns and to consult a veterinarian to determine the most appropriate heartworm preventative for dogs in such areas.

How Does the Lifestyle of a Dog Affect the Need for ProHeart 12?

Dogs with varied lifestyles may have differing risk levels for heartworm disease. For instance, dogs that spend substantial time outdoors, especially in regions with high mosquito populations, may be at an increased risk. ProHeart 12 serves as a robust preventative option for such high-risk dogs, ensuring consistent protection due to its extended duration of action.

What Should Be Done in Case of Missed Doses or Late Administration?

If a dog misses a dose of ProHeart 12 or if the administration is delayed beyond the 12-month interval, it is vital to consult a veterinarian promptly. The veterinarian may recommend immediate administration of ProHeart 12 and reestablishing the regular annual dosing schedule, but this might also necessitate a heartworm test prior to restarting the medication.

Are There Any Behavioral Changes to Expect After Administration?

Typically, dogs do not exhibit behavioral changes post-ProHeart 12 administration. However, if any alterations in behavior, activity levels, or general demeanor are noticed, it is advisable to contact a veterinarian, as these could be subtle indicators of an adverse reaction or discomfort.

How Does the Cost of ProHeart 12 Compare to Monthly Preventatives?

While the upfront cost of ProHeart 12 might be higher compared to monthly preventatives, it is intended to provide 12 months of protection, potentially making it a cost-effective option in the long run. It’s beneficial for pet owners to assess their financial preferences and convenience factors when choosing between ProHeart 12 and monthly alternatives.

What Support and Resources Are Available for Pet Owners Choosing ProHeart 12?

Manufacturers and veterinarians often provide extensive resources and support for pet owners opting for ProHeart 12. This includes educational materials, reminders for annual administration, and sometimes even financial incentives or rebates. Leveraging these resources ensures that pet owners are well-informed and can optimize the benefits of choosing ProHeart 12.

How Does ProHeart 12 Contribute to a Comprehensive Parasite Prevention Program?

Incorporating ProHeart 12 into a comprehensive parasite prevention program necessitates an understanding of its specific actions against heartworm and hookworms. For complete protection against other parasites like fleas, ticks, and various intestinal worms, additional preventatives or treatments might be required, highlighting the importance of a holistic approach and regular veterinary consultations.

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